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Chemical Structure| 3745-79-7 Chemical Structure| 3745-79-7

Structure of 3745-79-7

Chemical Structure| 3745-79-7

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Product Details of [ 3745-79-7 ]

CAS No. :3745-79-7
Formula : C4H2ClNOS
M.W : 147.58
SMILES Code : O=C(Cl)C1=CSC=N1
MDL No. :MFCD08056320

Safety of [ 3745-79-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P363-P405-P501
Class:8
UN#:1759
Packing Group:

Application In Synthesis of [ 3745-79-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3745-79-7 ]

[ 3745-79-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 3973-08-8 ]
  • [ 3745-79-7 ]
YieldReaction ConditionsOperation in experiment
99% With thionyl chloride; for 2h;Heating / reflux; Preparation 96A; Thiazole-4-carbonyl chlorideA mixture of thiazole-4-carboxylic acid (30.0 g, 232 mmol) and thionyl chloride (200 ml.) was heated at reflux for 2h. The resulting solution was evaporated and the residue dried giving a yellow solid. Yield 34.0 g, 99%. 1H NMR (CDCI3) delta 8.91 (d, 1H, J = 2 Hz)1 8.49 (d, 1H, J = 2 Hz).
80.5% With thionyl chloride; for 2h;Reflux; Weigh 0.25g (1.94mmol)<strong>[3973-08-8]Thiazole-4-carboxylic acid</strong> in a 50 mL round bottom bottle,2.81 mL of thionyl chloride was added and stirred at reflux for 2 h.The reaction was monitored by TLC (methanol: dichloro = 1:2).The reaction solution was concentrated under reduced pressure to give a pale yellow solid.0.23g (1.56mmol),The yield was 80.50%.
With oxalyl dichloride; In dichloromethane; at 0℃; for 1h; Step A:; To an ice-cold solution of 1,3-thiozol-4-carboxylic acid (276 mg, 2.14 mmol) in dichloromethane (20 mL) was added oxalyl chloride (0.21 mL, 2.14 mmol) dropwise. The ice bath was removed and stirring was continued for 1 h. 2-Amino-3-hydroxybenzoic acid hydrobromide (500 mg, 2.14 mmol) was added followed by triethylamine (0.90 mL, 6.42 mmol). The resulting reaction mixture was stirred at room temperature overnight. The reaction was quenched with aqueous 1 N HCl (25 mL), until the solution reached pH 1. The reaction mixture was extracted with dichloromethane. The combined organic layers were dried over Na2SO4, filtered and concentrated to a brown solid. The crude was dissolved in toluene (10 mL) and the solution was treated with p-toluenesulfonic acid monohydrate (458 mg, 2.40 mmol). The resulting reaction mixture was then heated to reflux under nitrogen for 2 h. The reaction was cooled down to room temperature, poured into water and extracted with ethyl acetate (400 mL). The organic layer was separated then washed with water, brine, dried over Na2SO4, filtered and concentrated to an off-white solid. The crude product was purified by recrystallization from ethyl acetate to afford the desired product (145 mg, 27%) as a light yellow solid: 1H NMR (500 MHz, DMSO-d6) delta 13.25 (br s, 1H), 9.37 (d, J=1.9 Hz, 1H), 8.82 (d, J=1.9 Hz, 1H), 8.06 (dd, J=7.2, 0.9 Hz, 1H), 7.94 (dd, J=7.8, 0.9 Hz, 1H), 2.87 (t, J=7.9 Hz, 1H); MS (ESI+) m/z 247 (M+H).
With thionyl chloride; EXAMPLE 23 Thiazole-4-carbonyl chloride <strong>[3973-08-8]Thiazole-4-carboxylic acid</strong>, 0.97 g, is refluxed 1 1/2 hours with 10 ml thionyl chloride, evaporated, flushed with benzene and recrystallized from 50 ml hexane to yield thiazole-4-carbonyl chloride, m.p. 85. IR (mu, CHCl3): 5.64. NMR (delta, CDCl3): 9.01d, 8.59d, J=2.
With thionyl chloride; for 2h;Reflux; General procedure: I (1-1.5 eq.) was refluxed in SOCl2 (3-5 ml) for 2 h. An excess of SOCl2 was evaporated in vacuo and pyridine (3 ml) was added to the resulting residue. The mixture was then stirred for 10 min., IV (1 mmol) was added and the resulting mixture was stirred overnight at rt
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20℃;Inert atmosphere; A suspension of Ala (10.0 g, 77.4 mmol, Combi Blocks) in DCM (100 mL) is treated with oxalyl chloride (66.0 mL, 619.5 mmol). Then, DMF (599.6 iL, 7.7 mmol) is added dropwise. The reaction mixture is stirred overnight at RT, and then concentrated under reduced pressure, azeotroped with toluene (150 mL) and dried under high vacuum for 1 h to afford Alb which is used as is in subsequent reactions.
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20℃; Example Al: Preparation of compound Al bHO cIAla AlbAla (10.0 g, 77.4 mmol, Combi Blocks) in DCM (100 mL) is treated with oxalyl chloride (66.0 mL, 619.5 mmol). DMF (599.6 iL, 7.7 mmol) is then added dropwise causing gas evolution. The reaction mixture is stirred overnight at RT, and then concentrated under reduced pressure, azeotroped with toluene (150 mL) and dried under high vacuum for 1 h to afford Alb which is used as is in subsequent reactions.
With thionyl chloride; for 2h;Heating / reflux; Preparation of nitrile intermediates (Method A); The desired carboxylic acid (1 g) was refluxed in 10 ml of SOCI2 for 2h. SOCI2 was removed under reduced pressure. Dry toluene was added. The solution was cooled to O0C with ice bath. Ammonia was bubbled in toluene for 30 min. Solid was filtered and the filtrate was concentrated to obtain the crude amide which was used to next step without further purification.To a stirred mixture of amide (1.0 eq) and Et3N (4.5eq) was added dropwise (CF3CO)2theta (TFFA, 2 eq) at - 780C under N2. The mixture was stirred overnight at room temperature. Ice water was added to destroy TFAA. The mixture was extracted with CH2Cl2. The organic phases were combined, dried over Na2Stheta4 and concentrated to afford the product.
With oxalyl dichloride;N,N-dimethyl-formamide; In dichloromethane; at 20 - 35℃; To l,3-thiazole-4-carboxylic acid (0.423 g, 3.28 mmol) in CH2Cl2 (10 mL) was added oxalyl chloride (0.34 mL, 3.93 mL) and DMF (5 drops). The reaction was warmed momentarily Io about 30-35 0C and then stirred at rt for 2 h. The reaction was concentrated to afford the product

  • 2
  • [ 156118-16-0 ]
  • [ 3745-79-7 ]
  • [ 1027712-06-6 ]
YieldReaction ConditionsOperation in experiment
In dichloromethane; at 40℃; for 16h; A solution of 1 ,3-thiazole-4-carbonyl chloride (142 mg) and 6-bromo-4-methyl-3- pyridinamine (18 mg) in DCM (1 mL) was stirred in a Reactivial under nitrogen at 4O0C for 16 h. The reaction mixture was evaporated in vacuo and partitioned between DCM and water. The organic phase was separated and evaporated in vacuo. The crude material was purified using a 4 g silica ISCO cartridge eluting with a gradient of 0-30% EtOAc to give the title compound.MS calcd for (C10H8BrN3OS + H)+ : 298 / 300 MS found (electrospray) : (M+H)+ = 298 / 300
 

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