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Chemical Structure| 372120-51-9 Chemical Structure| 372120-51-9

Structure of 372120-51-9

Chemical Structure| 372120-51-9

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Product Details of [ 372120-51-9 ]

CAS No. :372120-51-9
Formula : C8H8F3NO
M.W : 191.15
SMILES Code : OCC1=CC=C(C(F)(F)F)C(N)=C1
MDL No. :MFCD18072583

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Application In Synthesis of [ 372120-51-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 372120-51-9 ]

[ 372120-51-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 372120-51-9 ]
  • [ 372120-55-3 ]
  • 2
  • [ 372120-51-9 ]
  • [ 372120-54-2 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; sodium nitrite;copper(I) bromide; In water; hydrogen bromide; EXAMPLE 63A [3-bromo-4-(trifluoromethyl)phenyl]methanol The product from Example 62B (0.76 g, 4 mmol) in water (8 mL) at 0 C. was treated with concentrated H2SO4 (3 mL) and then treated dropwise with an aqueous solution of sodium nitrite (0.41 g, 6 mmol) keeping the temperature below 10 C. After stirring for 1 hour, this solution was added to a solution of copper(I) bromide (0.85 g, 5 mmol) in 48% hydrobromic acid (50 mL). The reaction mixture was heated at 60 C. for 3 hours, cooled to ambient temperature and partitioned between water and ethyl acetate. The organic layer was washed with aqueous sodium carbonate, dried over MgSO4 and concentrated to provide the title compound contaminated with approximately 30% of 2-bromo-4-(bromomethyl)-1-(trifluoromethyl)benzene.
 

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