Home Cart Sign in  
Chemical Structure| 37059-57-7 Chemical Structure| 37059-57-7

Structure of 37059-57-7

Chemical Structure| 37059-57-7

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 37059-57-7 ]

CAS No. :37059-57-7
Formula : C7H10N2
M.W : 122.17
SMILES Code : CCNC1=NC=CC=C1
MDL No. :MFCD04038418

Safety of [ 37059-57-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H227-H315-H319
Precautionary Statements:P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P370+P378-P403+P235-P501

Application In Synthesis of [ 37059-57-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 37059-57-7 ]

[ 37059-57-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 37059-57-7 ]
  • (-)-1R,2S-N-methylephedrine [ No CAS ]
  • [ 172366-38-0 ]
  • (R)-(+)-2-hydroxy-5,7-difluoro-1,2,3,4-tetrahydronaphthalene [ No CAS ]
YieldReaction ConditionsOperation in experiment
47% With hydrogenchloride; In diethyl ether; hexane; (R)-(+)-2-Hydroxy-5,7-difluoro-1,2,3,4-tetrahydronaphthalene. A solution of (-)-1R,2S-N-methylephedrine (81.3 g, 0.454 mol) in anhydrous Et2O (1.1 L) was added dropwise (45 min) to 1.0 M lithium aluminum hydride (416 mL, 0.416 mol) in Et2O at a rate sufficient to maintain a gentle reflux. After the addition was complete, the reaction mixture was heated at reflux for 1 h then allowed to cool to room temperature. A solution of 2-ethylaminopyridine (111 g, 0.98 mole) in anhydrous Et2O (100 mL) was added (45 min) at such a rate as to maintain a gentle reflux. The reaction mixture was heated at reflux for a further 1 h, during which time a light yellow-green suspension appeared. The mixture was cooled to an internal temperature of -65 C. using a dry ice-acetone bath and a solution of <strong>[172366-38-0]5,7-difluoro-2-tetralone</strong> (23.0 g, 126 mmol) in Et2O (125 mL) was added dropwise at a rate maintaining the internal temperature below -60 C. After the addition was complete, the mixture was stirred at -65 C. to -68 C. for 3 h and quenched by the addition of MeOH (100 mL) maintaining the internal temperature below -60 C. The reaction was stirred for a further 10 min at -65 C. and allowed to warm to approximately -20 C. A solution of 3N HCl (2 L) was then added at a rate to limit the temperature to <35 C. After stirring at an increased rate to achieve total dissolution, the layers were separated and the ethereal layer was washed with brine (200 mL) and dried (MgSO4). The ethereal solution was evaporated under reduced pressure and the residue dissolved in warm Et2O (20 mL) followed by the addition of hexane (200 mL). The seeded solution was cooled in an ice bath and maintained at 0 C. for 1 h whereupon the resulting deposited crystals were collected and dried in vacuo to give the alcohol (10.9 g, 47%): mp 85 C.; [α]25D +38.1 (c=1.83, CHCl3); 93.4% ee by chiral HPLC: 1H NMR (CDCl3) δ 1.70 (br s, 1H), 1.76-1.88 (m, 2H), 1.99-2.06 (m, 2H), 2.63-3.08 (m, 3H), 4.15 (m, 1H), 6.60 (m, 2H). Anal. Calcd for C10H10F2O: C, 65.21; H, 5.47. Found: C, 65.38: H, 5.42. The spectra for the (S)-enantiomer 4b are identical: mp 84-85 C.; [α]25D -37.8 (c=1.24, CHCl3); 92.4% ee by chiral HPLC. Anal. Calcd for C10H10F2O: C, 65.21; H, 5.47. Found: C, 65.47; H, 5.39.
 

Historical Records

Technical Information

Categories