3704-41-4|2-(4-Nitrophenyl)thiazole| Ambeed

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 3704-41-4 ] Purity: 95% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 3704-41-4 ]

CAS No. :	3704-41-4
Formula :	C₉H₆N₂O₂S
M.W :	206.22
SMILES Code :	O=[N+](C1=CC=C(C2=NC=CS2)C=C1)[O-]
MDL No. :	MFCD26794836
InChI Key :	LGDOGDJADXLHLA-UHFFFAOYSA-N
Pubchem ID :	13546655

Safety of [ 3704-41-4 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H320-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 3704-41-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 3704-41-4 ]

[ 3704-41-4 ] Synthesis Path-Downstream 1~35

1
[ 1826-11-5 ]
[ 3704-41-4 ]

Yield	Reaction Conditions	Operation in experiment
58.6%	With sulfuric acid; nitric acid; In water; at 0℃; for 1h;	A solution of 2-phenyl thiazole (200mg, 1.24mmol) in cone, sulphuric acid (0.5ml) was cooled to O0C. The nitrating mixture (made up of 0.5ml of cone, nitric acid and 0.5ml of cone, sulfuric acid) was added dropwise and stirred at O0C for lhr. The reaction was quenched with ice water and basified with sodium hydroxide solution. The resultant precipitate was filtered and washed with water. Purification by column chromatography over silica gel using EtOAc/ pet ether gave 2-(4-nitrophenyl) thiazole (150mg, 58.6%) as solid.

References: [1]Patent: WO2006/123145,2006,A1 .Location in patent: Page/Page column 68.
[2]Journal of the American Chemical Society,1937,vol. 59,p. 2262.

2
[ 3704-41-4 ]
[ 193017-26-4 ]

Yield	Reaction Conditions	Operation in experiment
88%	With iron; In acetic acid; at 20℃; for 2h;	Iron powder (0.5g, 8.92mmol) was added portion wise to a solution of 2-(4- nitrophenyl)-thiazole (200mg, 0.97mmol) in acetic acid (5ml) and stirred at room temperature for 2hr. The reaction mixture was diluted with water, basified with dilute sodium hydroxide, filtered and the filtrate was extracted with ethyl acetate. The organic layer was washed with water, brine and dried. Evaporation of the solvent yielded 4- thiazol-2-yl-phenylamiiie (150mg, 88%) as solid.

References: [1]Patent: WO2006/123145,2006,A1 .Location in patent: Page/Page column 69.
[2]Journal of the American Chemical Society,1937,vol. 59,p. 2262.
[3]Helvetica Chimica Acta,1947,vol. 30,p. 2058,2061.
[4]Journal of Pharmaceutical Sciences,1969,vol. 58,p. 852 - 857.

3
[ 3704-41-4 ]
[ 193017-26-4 ]
bis-(4-thiazol-2-yl-phenyl)-diazene-<i>N</i>-oxide [ No CAS ]

References: [1]Helvetica Chimica Acta,1947,vol. 30,p. 2058,2061.

5
[ 288-47-1 ]
[ 636-98-6 ]
[ 3704-41-4 ]

Yield	Reaction Conditions	Operation in experiment
	With N,N'-disalicylideneethylenediamine; caesium carbonate;copper(l) iodide; cobalt(II) acetate; In 1,4-dioxane; at 150℃; for 10h;	Preparation of 4-[2-(4-Nitro-phenyl)-6-oxo-4-thioxo-6H-1-thia-3,3b,5-triaza-cyclopenta[a]pentalen-5-yl]-butyric acid ethyl ester (Compound 37) As depicted in Scheme 24 below, anhydrous Co(OAc)2 (0.021 mmol, 5%) and SALEN (2,2'-(1,4-diiminobutane-1,4-diyl)diphenol, 0.041 mmol, 0.1 molequivalent) in 0.5 ml dry dioxane are placed in a flame-dried flask, and the mixture is stirred for 10 minutes at room temperature. A solution of thiazole (0.411 mmol) in 1 ml dry dioxane, anhydrous Cs2CO3 (0.493 mmol, 1.2 molequivalents) and CuI (0.822 mmol, 2 molequivalents) are thereafter added consecutively to the reaction mixture under argon. A solution of 4-nitrophenyl iodide (0.493 mmol, 1.2 molequivalents) in dry dioxane (0.5 ml) is then added dropwise and the resulting mixture is heated to 150 C. under argon, while monitoring the reaction progress by TLC. Once the reaction is completed (after about 10 hours), the resulting mixture is diluted with chloroform (20 ml) and filtered through a celite pad. The organic solvents are evaporated under reduced pressure and the crude product is purified by flash column chromatography, using a hexane:ethyl acetate mixture as eluent, to give pure 2-[4-nitrophenyl]thiazole.

References: [1]Patent: US2008/39456,2008,A1 .Location in patent: Page/Page column 56.

6
[ 3704-41-4 ]
[ 25020-24-0 ]

References: [1]Journal of Pharmaceutical Sciences,1969,vol. 58,p. 852 - 857.

7
[ 3704-41-4 ]
[ 25020-25-1 ]

References: [1]Journal of Pharmaceutical Sciences,1969,vol. 58,p. 852 - 857.

8
[ 3704-41-4 ]
[ 25020-38-6 ]

References: [1]Journal of Pharmaceutical Sciences,1969,vol. 58,p. 852 - 857.

9
[ 3704-41-4 ]
[ 25020-27-3 ]

References: [1]Journal of Pharmaceutical Sciences,1969,vol. 58,p. 852 - 857.

10
[ 3704-41-4 ]
[ 25020-26-2 ]

References: [1]Journal of Pharmaceutical Sciences,1969,vol. 58,p. 852 - 857.

11
[ 3704-41-4 ]
[ 25020-36-4 ]

References: [1]Journal of Pharmaceutical Sciences,1969,vol. 58,p. 852 - 857.

12
[ 3704-41-4 ]
[ 25020-28-4 ]

References: [1]Journal of Pharmaceutical Sciences,1969,vol. 58,p. 852 - 857.

13
[ 3704-41-4 ]
[ 25020-37-5 ]

References: [1]Journal of Pharmaceutical Sciences,1969,vol. 58,p. 852 - 857.

14
[ 4394-85-8 ]
[ 3704-41-4 ]
[ 185245-02-7 ]

Yield	Reaction Conditions	Operation in experiment
		As depicted in Scheme 25 below, <strong>[3704-41-4]2-(4-nitrophenyl)thiazole</strong> (19.9 mmol) dissolved in ether (20 ml) is added dropwise over 1 hour to a stirred and cooled (-78 C.) solution of butyl lithium (1.5 M) in n-hexane (20 ml, 29.9 mmol), diluted with ether (50 ml). The mixture is stirred at -78 C. for 30 minutes and then a solution of N-formylmorpholine (29.9 mmol) in ether (30 ml) is added dropwise over a time period of 15 minutes. After 30 minutes at -78 C., the mixture is washed with saturated aqueous NaHCO3 (30 ml) and extracted with ether (2*20 ml). The organic phase is dried over Na2SO4 and the solvent is removed under reduced pressure to give the crude <strong>[3704-41-4]2-(4-Nitro-phenyl)-thiazol</strong>e-5-carbaldehyde.

References: [1]Patent: US2008/39456,2008,A1 .Location in patent: Page/Page column 56-57.

15
[ 2518-13-0 ]
[ 3704-41-4 ]

References: [1]Chemistry - An Asian Journal,2013,vol. 8,p. 1408 - 1411.

16
[ 619-72-7 ]
[ 3704-41-4 ]

References: [1]Chemistry - An Asian Journal,2013,vol. 8,p. 1408 - 1411.

17
[ 288-47-1 ]
[ 3466-32-8 ]
[ 3704-41-4 ]

References: [1]Chemical Science,2013,vol. 5,p. 123 - 135.

18
[ 3704-41-4 ]
[ 141-32-2 ]
(E)-butyl 3-(2-(4-nitrophenyl)thiazol-5-yl)acrylate [ No CAS ]

References: [1]Chemical Communications,2015,vol. 51,p. 4599 - 4602.

19
[ 2227-79-4 ]
[ 3704-41-4 ]

References: [1]Patent: WO2006/123145,2006,A1 .

20
[ 288-47-1 ]
[ 456-27-9 ]
[ 3704-41-4 ]

References: [1]Chemical Science,2017,vol. 8,p. 7798 - 7806.

21
[ 3704-41-4 ]
2-(4-nitrophenyl)-4H-pyrrolo[2,3-d]-thiazole-5-carboxylic acid ethyl ester [ No CAS ]

References: [1]Patent: US2008/39456,2008,A1 .

22
[ 3704-41-4 ]
4-[2-(4-Nitro-phenyl)-6-oxo-4-thioxo-6H-1-thia-3,3b,5-triaza-cyclopenta[a]pentalen-5-yl]-butyric acid ethyl ester [ No CAS ]

References: [1]Patent: US2008/39456,2008,A1 .

23
[ 3704-41-4 ]
C₁₄H₁₁N₅O₄S [ No CAS ]

References: [1]Patent: US2008/39456,2008,A1 .

24
[ 3034-53-5 ]
[ 24067-17-2 ]
[ 3704-41-4 ]