Home Cart Sign in  
Chemical Structure| 368-78-5 Chemical Structure| 368-78-5
Chemical Structure| 368-78-5

3-(Trifluoromethyl)phenylhydrazine

CAS No.: 368-78-5

4.5 *For Research Use Only !

Cat. No.: A374459 Purity: 95%

Change View

Size Price

US Stock

Global Stock

In Stock
10g łÇÍď¶ÊÊ Inquiry 1-2 weeks
25g ł§§ò¶ÊÊ Inquiry 1-2 weeks

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 10g

    łÇÍď¶ÊÊ

  • 25g

    ł§§ò¶ÊÊ

In Stock

- +

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 368-78-5 ]

CAS No. :368-78-5
Formula : C7H7F3N2
M.W : 176.14
SMILES Code : NNC1=CC(=CC=C1)C(F)(F)F
MDL No. :MFCD00025093

Safety of [ 368-78-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 368-78-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 368-78-5 ]

[ 368-78-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2689-69-2 ]
  • [ 368-78-5 ]
  • 3-[(3-trifluoromethyl-phenyl)-hydrazono]-tetrahydro-thiophene-2-carboxylic acid methyl ester [ No CAS ]
  • 2
  • [ 1218-69-5 ]
  • [ 368-78-5 ]
  • 2,2'-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazole-3,5-diyl)diphenol [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% In methanol; at 65℃; for 2h; A mixture of CC (100 mg, 0.4 mmol) and (3-(trifluoromethyl)phenyl)hydrazine (79 mg, 0.4 mmol) in anhydrous methanol(20 mL) was heated at 65 C for 2 h, and then cooled to 15 C. Filterthe cooling liquid. Reddish brown crystals were collected in a yieldof 90%. (150 mg, 0.4 mmol). m.p. 242.1e244.6 C. 1H NMR(500 MHz, DMSO-d6) d10.78 (s, 1H), 10.10 (s, 1H), 8.07 (dd,J1 7.8 Hz, J2 1.5 Hz, 1H), 7.80 (dd, J1 11.6 Hz, J2 7.0 Hz, 3H),7.74e7.68 (m, 1H), 7.57 (dd, J1 7.6 Hz, J2 1.5 Hz, 1H), 7.43e7.34(m, 2H), 7.07e6.96 (m, 3H), 6.88 (d, J 8.2 Hz, 1H). 13C NMR(100 MHz, DMSO) d(ppm) 160.39, 156.81, 155.60, 152.63, 138.89,133.07, 131.94, 131.60, 131.07, 130.285(q, 2JC-F 32.6 Hz), 127.86,127.32, 125.63(q, 3JC-F 3.7 Hz), 124.14(q, 1JC-F 272.3 Hz), 120.57(q, 3JC-F 3.9 Hz), 120.15, 119.92, 117.54, 116.53, 114.66, 114.14. 19FNMR (376.5 MHz, DMSO) d(ppm) 61.388. ESI-MS: m/z. Calculatedfor C21H14F3N3O2 397.10; found [MH] 398.1111.
90% In methanol; at 6℃; for 2h; Compound IV (100 mg, 0.4 mmol) and 3-trifluoromethylphenylhydrazine (V) (79 mg, 0.4 mmol) were dissolved in anhydrous methanol (20 mL), and the mixture was heated at 6 C for 2 hr. After the reaction was completed, the reaction solution was cooled to 15 C, and crystals were precipitated.Filtration gave reddish brown crystals (150 mg, 0.4 mmol), product (I). The yield was 90%.
 

Historical Records

Technical Information

Categories