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Chemical Structure| 36768-62-4 Chemical Structure| 36768-62-4
Chemical Structure| 36768-62-4

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Product Details of 4-Amino-2,2,6,6-tetramethylpiperidine

CAS No. :36768-62-4
Formula : C9H20N2
M.W : 156.27
SMILES Code : CC1(C)CC(N)CC(C)(C)N1
MDL No. :MFCD00005984
InChI Key :FTVFPPFZRRKJIH-UHFFFAOYSA-N
Pubchem ID :37524

Safety of 4-Amino-2,2,6,6-tetramethylpiperidine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H290-H302-H314-H412
Precautionary Statements:P234-P273-P280-P301+P312-P303+P361+P353-P305+P351+P338
Class:8
UN#:2735
Packing Group:

Application In Synthesis of 4-Amino-2,2,6,6-tetramethylpiperidine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 36768-62-4 ]

[ 36768-62-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 36768-62-4 ]
  • [ 2351-36-2 ]
  • C30H44N4O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% With triethylamine; lithium chloride; In DMF (N,N-dimethyl-formamide); at 0 - 65℃; for 5h; 83.75 g (0.26 mole) of 4-amino-2,2,6,6-tetramethylpiperidine are dissolved in 350 ml of N,N-dimethyl formamide, in a 750 ml round bottomed 3 necked reaction flask with stirrer, thermometer, funnel and reflux-condenser. 30.71 g (0.304 mole) and 8.5 g (0.2 mole) of lithium chloride are added under constant stirring at room temperature. The solution is cooled to 0 C. and during 1 hour 65.8 g (0.26 mole) of naphthalene-2,6-dicarbonyl-dichloride are added in small portions under vigourous stirring. A faintly yellow suspension results. The reaction mass is kept at 0-5 C. for 1 hour. Within a further hour, the temperature is raised to room temperature and then the whole is kept at 65 C for further 2 hours. The reaction product is then diluted with 200 ml of isopropanol/water (1/4). The reaction mixture is then poured on 600 ml of water, under stirring. Then, the solid residue is filtered off and subsequently washed with several portions of isopropanol/water (1/1). Afterwards, the solid is dried in a vacuum drier at 80 C. for 15 hours. The desired product is obtained as a colourless powder. Yield: 76, 1 g (=76% of theory). Melting-point: higher than 300 C.
  • 2
  • [ 36768-62-4 ]
  • [ 957230-70-5 ]
  • 5-bromo-N2-(2,2,6,6-tetramethylpiperidin-4-yl)pyrazine-2,3-diamine [ No CAS ]
YieldReaction ConditionsOperation in experiment
54% With N-ethyl-N,N-diisopropylamine; In ethanol; at 180℃; for 3.5h;Microwave irradiation; Step 1: To a solution of <strong>[957230-70-5]3,6-dibromopyrazin-2-amine</strong> (504 mg, 2 mmol) and 2, 2,6,6-tetramethylpiperidin-4-amine (0.35 mL, 2 mmol) in EtOH (2 mL) was added DIEA (0.38 mL, 2 mmol). The reaction mixture was subjected to microwave irradiation at 180 C for 3.5 h. The reaction mixture was cooled and concentrated. The residue was purified by silica gel column chromatography eluting with a MeOH (2.5% NH40H)/CH2Cl2 gradient (0-30% MeOH/NH4OH) to provide 5-bromo-N2-(2, 2, 6, 6-tetramethylpiperidin-4-yl)pyrazine-2, 3-diamine (0.35 g, 54%). MS m/z 328.0, 330.0 [M+H]+.
 

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