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Chemical Structure| 364793-56-6 Chemical Structure| 364793-56-6

Structure of 364793-56-6

Chemical Structure| 364793-56-6

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Product Details of [ 364793-56-6 ]

CAS No. :364793-56-6
Formula : C10H5BrN2O
M.W : 249.06
SMILES Code : N#CC1=CNC2=C(C=CC(Br)=C2)C1=O

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Application In Synthesis of [ 364793-56-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 364793-56-6 ]

[ 364793-56-6 ] Synthesis Path-Downstream   1~2

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YieldReaction ConditionsOperation in experiment
93% In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; REFERENCE EXAMPLE 5 7-Bromo-4-chloro-3-quinolinecarbonitrile To suspension of 7-bromo-4-oxo-1,4-dihydroquinoline-3-carbonitrile (1.0 g, 4.02 mmol) in methylene chloride was added oxalyl chloride (1.75 mL, 20 mmol) followed by dimethylformamide (78 muL, 1.00 mmol). The mixture was stirred at room temperature for 3 hours and additional oxalyl chloride (1.75 miL, 20 mmol) and dimethylformamide (78 L, 1.00 mmol) were added. The reaction mixture was stirred at room temperature overnight and then diluted with methylene chloride. Ice water was added and the aqueous layer was basified to pH 9 with sodium carbonate. The organic layer was washed with water, dried over magnesium sulfate, filtered and concentrated in vacuo to provide 1.0 g (93% yield) of 7-bromo-4-chloro-3-quinolinecarbonitrile as a light yellow solid; 1H NMR (DMSO- d6) delta 8.07 (dd, J=9, 2 Hz, 1H), 8.26 (d, J=9 Hz, 1H), 8.46 (d, J=2 Hz, 1H), 9.22 (s, 1H); MS (ES) m/z 268.7 (M +1)-1H-. Analysis for C10H4 BrClN2 : Calcd: C, 44.90;H, 1.51; N, 10.47; Br, 29.87;Cl, 13.25. Found: C, 45.00;H, 1.76; N, 10.40; Br, 30.25;Cl, 13.47.
 

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