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[ CAS No. 36157-42-3 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 36157-42-3
Chemical Structure| 36157-42-3
Structure of 36157-42-3 *Storage: {[proInfo.prStorage]}

Quality Control of [ 36157-42-3 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 36157-42-3 ]

SDS

Product Details of [ 36157-42-3 ]

CAS No. :36157-42-3MDL No. :MFCD00082877
Formula : C5H3ClO2S Boiling Point : 287°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :162.59Pubchem ID :819049
Synonyms :

Computed Properties of [ 36157-42-3 ]

TPSA : 65.5 H-Bond Acceptor Count : 3
XLogP3 : 2.1 H-Bond Donor Count : 1
SP3 : 0.00 Rotatable Bond Count : 1

Safety of [ 36157-42-3 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 36157-42-3 ]

  • Downstream synthetic route of [ 36157-42-3 ]

[ 36157-42-3 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 36157-42-3 ]
  • 5-chloro-thiophene-3-carboxylic acid anilide [ No CAS ]
  • 2
  • [ 36157-42-3 ]
  • [ 36157-41-2 ]
  • 3
  • [ 36157-42-3 ]
  • 5-chloro-thiophene-3-carboxylic acid amide [ No CAS ]
YieldReaction ConditionsOperation in experiment
...stead of cyclopentane carboxylic acid to yield the appropriate 25-substituted avermectins of formula (I) wherein R is H, R1 is OH, or R and R1 taken together represent a double bond, R3 is H or OH and R4 is 4'-(alpha-L-oleandrosyl)-alpha-L-oleandrosyloxy: ... tetrahydropyran-4-carboxylic acid 3-furoic acid and <strong>[36157-42-3]2-chloro-thiophene-4-carboxylic acid</strong>.
  • 5
  • [ 36157-42-3 ]
  • [ 1413936-87-4 ]
  • benzyl 2-{[(5-chlorothiophen-3-yl)carbamoyl]amino}-2-ethylbutanoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
28% Diphenylphosphoryl azide (508 mg, 1.85 mmol) was added to a tetrahydrofuran (8 mL) suspension of <strong>[36157-42-3]5-chlorothiophene-3-carboxylic acid</strong> () (250 mg, 1.54 mmol) and triethylamine (298 muL, 2.15 mmol), the resultant was stirred at room temperature for 7 minutes, and then, N,N-dimethylformamide (3 mL) was added thereto, followed by stirring at room temperature for 80 minutes. Benzyl 2-amino-2-ethylbutanoic acid (, ) (408 mg, 1.85 mmol) was added thereto, followed by stirring at 70C for 4.5 hours. The resultant was cooled to room temperature, saturated sodium bicarbonate was added thereto, and the resultant was extracted with ethyl acetate. The thus obtained extract was washed successively with water and a saturated saline solution, and dried over anhydrous sodium sulfate. A residue obtained through filtration and concentration under reduced pressure was purified by silica gel column chromatography [elution solvent: n-hexane/ethyl acetate = 9/1 - 3/1 (V/V)] to obtain 162 mg (28%) of the title compound in the form of a white solid. 1H-NMR (400MHz, CDCl3) delta: 7.36-7.30 (5H, m), 6.83 (1H, d, J = 2.0 Hz), 6.78 (1H, d, J = 2.0 Hz), 6.40 (1H, s), 5.64 (1H, s), 5.16 (2H, s), 2.46-2.37 (2H, m), 1.85-1.76 (2H, m), 0.70 (6H, t, J = 7.4 Hz).
  • 6
  • [ 36157-42-3 ]
  • [ 908093-98-1 ]
  • 5-Chloro-thiophene-3-carboxylic acid benzhydryl ester [ No CAS ]
  • 7
  • [ 36157-42-3 ]
  • C18H14ClN5OS [ No CAS ]
  • 8
  • [ 36157-42-3 ]
  • [ 1351753-37-1 ]
  • 9
  • [ 36157-42-3 ]
  • C30H21BrClOPS [ No CAS ]
  • 10
  • [ 36157-42-3 ]
  • [ 1351753-35-9 ]
Historical Records

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