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Chemical Structure| 357396-06-6 Chemical Structure| 357396-06-6

Structure of 357396-06-6

Chemical Structure| 357396-06-6

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Product Details of [ 357396-06-6 ]

CAS No. :357396-06-6
Formula : C11H11ClO3
M.W : 226.66
SMILES Code : O=C(C1CCC2=C(O1)C=CC(Cl)=C2)OC

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Application In Synthesis of [ 357396-06-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 357396-06-6 ]

[ 357396-06-6 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 186581-53-3 ]
  • [ 40026-24-2 ]
  • [ 357396-06-6 ]
  • 2
  • [ 357396-06-6 ]
  • [ 40026-24-2 ]
YieldReaction ConditionsOperation in experiment
With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20℃; for 2.0h; General procedure: To a stirred solution of 2a-f in THF (2 mL) and MeOH (1 mL),0.25 M aqueous LiOH (1.05 equiv) was added dropwise at roomtemperature and stirred for 2 h. The reaction mixture was concentratedunder reduced pressure and then acidified with dil HCl. Thecrude product was extracted with ethyl acetate and concentrated.This organic layer was dried over anhydrous MgSO4, filtered, andevaporated under reduced pressure. The concentrate was furtherpurified by crystallization with n-hexane to afford 6a-f.
  • 3
  • [ 67-56-1 ]
  • [ 40026-24-2 ]
  • [ 357396-06-6 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; at 70℃; for 18.0h; To a stirred solution of <strong>[40026-24-2]6-chlorochroman-2-carboxylic acid</strong> (500 mg, 2.35 mmol) in methanol (7 mL) at room temperature was added concentrated sulfuric acid (2 drops). The resultant solution was stirred at 70 C. for 18 hours. The reaction mixture was neutralized with saturated NaHCO3 and was diluted with dichloromethane. The layers were separated and the aqueous layer was re-extracted with dichloromethane. The combined organic layers were passed through a hydrophobic frit and the filtrate was concentrated under reduced pressure to provide the title compound. 1H NMR (400 MHz, CDCl3) delta ppm 6.89-6.79 (m, 2H), 6.74 (dd, J=2.9, 8.8 Hz, 1H), 4.71 (dd, J=3.6, 7.4 Hz, 1H), 3.79 (s, 3H), 2.86-2.69 (m, 2H), 2.31-2.12 (m, 2H).
 

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