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Chemical Structure| 357263-39-9 Chemical Structure| 357263-39-9

Structure of 357263-39-9

Chemical Structure| 357263-39-9

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Product Details of [ 357263-39-9 ]

CAS No. :357263-39-9
Formula : C12H16N2O
M.W : 204.27
SMILES Code : O=C(N1C[C@@H](C)NCC1)C2=CC=CC=C2
MDL No. :MFCD07368011

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Application In Synthesis of [ 357263-39-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 357263-39-9 ]

[ 357263-39-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 178308-61-7 ]
  • [ 357263-39-9 ]
  • [ 1095639-29-4 ]
  • [ 1095639-27-2 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 100.0℃; for 4.5h; EXAMPLE 29Preparation of (R)-(4-(4-chloro-7-cyanophthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone (JK-25A) and (R)-(4-(4-chloro-6-cyanophthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone (JK-25B) <strong>[178308-61-7]1,4-dichloro-6-cyanophthalazine</strong> (1.38 g, 6.16 mmol) and (R)-(3-methylpiperazin-1-yl)(phenyl)methanone (1.38 g, 6.78 mmol) were dissolved/suspended in N,N-diisopropylethylamine (2.15 mL) and NMP (3 mL), fitted with an argon balloon and heated at 100 C. for 4.5 hours. The reaction was taken up in ethyl acetate (80 mL) and washed with aqueous K2CO3 (10%), water, and saturated sodium chloride. The organics were dried (MgSO4) and evaporated to give a brown oil. Chromatography over silica gel with a gradient of hexanes/0-70% ethyl acetate gave two products. Product JK-25A was a yellow solid 1.14 g; product JK-25B was 392 mg of a yellow solid. Both compounds had MS (M+H)+=385.1.
 

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