Alternatived Products of [ 3546-50-7 ]
Product Details of [ 3546-50-7 ]
CAS No. : | 3546-50-7 |
MDL No. : | MFCD00127953 |
Formula : |
C4H7N5
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
125.13
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 3546-50-7 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 3546-50-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 3546-50-7 ]
- Downstream synthetic route of [ 3546-50-7 ]
- 1
-
[ 3546-50-7 ]
-
[ 517-21-5 ]
-
[ 700-81-2 ]
- 2
-
[ 18620-73-0 ]
-
[ 3546-50-7 ]
Reference:
[1]Angewandte Chemie - International Edition,2007,vol. 46,p. 2478 - 2484
[2]Chemistry - An Asian Journal,2011,vol. 6,p. 1252 - 1262
[3]Journal of Chemical Research, Miniprint,1992,p. 514 - 539
[4]Journal of Applied Chemistry,1957,vol. 7,p. 109,112
[5]Chemische Berichte,1906,vol. 39,p. 252
[6]Journal of the Chemical Society,1951,p. 474,478
Journal of the Chemical Society,1952,p. 4219,4224
[7]Journal of the Chemical Society,1955,p. 1113,1115
[8]Nucleosides and nucleotides,1999,vol. 18,p. 23 - 37
[9]Journal of Medicinal Chemistry,2004,vol. 47,p. 240 - 253
- 3
-
[ 3546-50-7 ]
-
[ 14036-53-4 ]
-
[ 452-06-2 ]
- 4
-
[ 7647-01-0 ]
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[ 18620-73-0 ]
-
tin dichloride
[ No CAS ]
-
[ 3546-50-7 ]
- 5
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[ 1004-38-2 ]
-
[ 3546-50-7 ]
-
[ 609-32-5 ]
-
[ 38944-17-1 ]
Yield | Reaction Conditions | Operation in experiment |
|
With hydrogenchloride; In ethanol; |
2,4-diamino-6-nitropyrido[2,3-d]pyrimidine (FIG. 15a) About 1 equivalent of <strong>[1004-38-2]2,4,6-triamino pyrimidine</strong> was suspended in about 50 ml of refluxing absolute ethanol with stirring under an atmosphere of nitrogen. Concentrated HCl was added dropwise to effect solution and as soon as solution occurred, about 1.2 equivalents of nitromalonaldehyde was added all at once. Within 10 minutes, a thick reddish voluminous precipitate started forming. TLC analysis indicated the presence of a yellow spot corresponding to that of the desired product along with staring materials. The reaction mixture was stirred at reflux for 3.5 hours, immediately diluted with 30 ml of water, cooled and neutralized with concentrated NH4 OH. The precipitate was collected on a funnel and was washed repeatedly with water to remove unreacted triamino pyrimidine to yield pure 2,4-diamino-6-nitropyrido[2,3-d]pyrimidine. |