sales@ambeed.com

Structure Search

List Search MOL Search Structure Search

Hello, Sign in

Home Cart 0 Sign in

X

[ CAS No. 354-38-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 354-38-1

Chemical Structure| 354-38-1

Chemical Structure| 354-38-1

Structure of 354-38-1 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 354-38-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 354-38-1 ]

SDS Specification

Alternatived Products of [ 354-38-1 ]

Product Details of [ 354-38-1 ]

CAS No. :	354-38-1	MDL No. :	MFCD00008008
Formula :	C₂H₂F₃NO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	NRKYWOKHZRQRJR-UHFFFAOYSA-N
M.W :	113.04	Pubchem ID :	67717
Synonyms :

Calculated chemistry of [ 354-38-1 ]

Physicochemical Properties

Num. heavy atoms :	7
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.5
Num. rotatable bonds :	1
Num. H-bond acceptors :	4.0
Num. H-bond donors :	1.0
Molar Refractivity :	14.83
TPSA :	43.09 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.9 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.47
Log Po/w (XLOGP3) :	0.12
Log Po/w (WLOGP) :	1.29
Log Po/w (MLOGP) :	-0.14
Log Po/w (SILICOS-IT) :	0.69
Consensus Log Po/w :	0.49

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-0.55
Solubility :	31.8 mg/ml ; 0.282 mol/l
Class :	Very soluble
Log S (Ali) :	-0.58
Solubility :	29.7 mg/ml ; 0.263 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-0.3
Solubility :	56.9 mg/ml ; 0.504 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.0

Safety of [ 354-38-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 354-38-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 354-38-1 ]
Downstream synthetic route of [ 354-38-1 ]

[ 354-38-1 ] Synthesis Path-Upstream 1~76

1
[ 55-21-0 ]
[ 75-05-8 ]
[ 381-73-7 ]
[ 359-38-6 ]
[ 354-38-1 ]
[ 100-47-0 ]

Reference： [1] Russian Journal of Organic Chemistry, 2004, vol. 40, # 4, p. 513 - 517

2
[ 354-38-1 ]
[ 74-88-4 ]
[ 815-06-5 ]

Reference： [1] Patent: US5952375, 1999, A,
[2] Patent: US2004/53999, 2004, A1,

3
[ 354-38-1 ]
[ 815-06-5 ]

Yield	Reaction Conditions	Operation in experiment
65%	With NaH In tetrahydrofuran; ethyl acetate; mineral oil	Example 6-B Trifluoroacetamide (300 mg; 0.63 mmol) in THF (2 mL) at 0° C. was treated with NaH 60percent dispersion in mineral oil (50 mg; 0.63 mmol) followed by Mel (60 μL; 0.94 mmol) and the reaction was stirred at room temperature overnight THF was evaporated, the residue was diluted with water and extracted with CH₂Cl₂. Combined organic layers were washed with saturated brine, dried over Na₂SO₄, concentrated and the crude was purified by flash chromatography over silica gel (eluding Hexanes/AcOEt 4:1 to 1:1) to give 200 mg (65percent) of N-methyltrifluoroacetamide.

Reference： [1] Patent: US2003/105094, 2003, A1,

4
[ 383-63-1 ]
[ 354-38-1 ]

Yield	Reaction Conditions	Operation in experiment
100%	With hydrogenchloride; triethylamine In ethanol; ethyl acetate	Example 5 Synthesis of Atropisomeric Trifluoroacetamide 3a Atropisomer 2a as the sulfate salt (0.93 gm, 1.84 mmoles, 503.4 MW) was dissolved in 15 ml ethanol. Triethylamine (1.8 ml, 13 mmoles) and ethyl trifluoroacetate (2.2 ml, 18 mmoles) were slowly added (FIG. 2a). The mixture was stirred at room temperature under argon for 2.5 hours. Volatiles were removed under vacuum and the resulting residue was dissolved in 300 ml ethyl acetate and washed with 2*50 ml of 5percent HCl. The ethyl acetate fraction was dried over anhydrous Na₂SO₄, filtered and concentrated under vacuum to yield atropisomeric trifluoroacetamide 3a as an orange solid (0.92 gm, 100percent yield, 501.4 MW). ¹H NMR (methanol-d4) δ8.35, 1H, d; 8.15, 1H, d; 7.80, 1H, s; 6.82, 1H, s; 6.65, 4H, m; 4.82, 2H, s.

Reference： [1] Patent: US6448407, 2002, B1,
[2] Journal of the American Chemical Society, 1943, vol. 65, p. 1459
[3] Journal of the American Chemical Society, 1943, vol. 65, p. 1459
[4] Journal of Organic Chemistry, 1959, vol. 24, p. 1256,1258
[5] Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1922, vol. <5>8, p. 346[6] Bulletin des Societes Chimiques Belges, 1923, vol. 32, p. 104[7] Chem. Zentralbl., 1923, vol. 94, # I, p. 66
[8] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, # 2, p. 341 - 348[9] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 2, p. 401 - 408
[10] Journal of the Chemical Society, Faraday Transactions, 1993, vol. 89, # 16, p. 2937 - 2944
[11] Journal of Organic Chemistry, 1988, vol. 53, # 11, p. 2573 - 2579
[12] Patent: US2003/143555, 2003, A1,
[13] Patent: US2003/158403, 2003, A1,
[14] Patent: US2013/150254, 2013, A1, . Location in patent: Page/Page column

5
[ 79-37-8 ]
[ 5875-25-2 ]
[ 354-38-1 ]

Reference： [1] Patent: US6288234, 2001, B1,

6
[ 76-05-1 ]
[ 354-38-1 ]

Reference： [1] Advanced Synthesis and Catalysis, 2012, vol. 354, # 13, p. 2531 - 2536

7
[ 89567-94-2 ]
[ 354-38-1 ]
[ 78238-44-5 ]

Reference： [1] Journal of Organic Chemistry USSR (English Translation), 1983, p. 2314 - 2315[2] Zhurnal Organicheskoi Khimii, 1983, vol. 19, # 12, p. 2632 - 2633

8
[ 14618-49-6 ]
[ 354-38-1 ]

Reference： [1] Chemistry - A European Journal, 2007, vol. 13, # 23, p. 6590 - 6594

9
[ 84353-59-3 ]
[ 354-38-1 ]

Reference： [1] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 9, p. 3374 - 3376

10
[ 383-63-1 ]
[ 111-40-0 ]
[ 354-38-1 ]

Reference： [1] Patent: US2009/124692, 2009, A1,

11
[ 359-45-5 ]
[ 354-38-1 ]
[ 78162-82-0 ]
[ 78162-82-0 ]

Reference： [1] Canadian Journal of Chemistry, 1981, vol. 59, p. 431 - 450

12
[ 233257-02-8 ]
[ 354-38-1 ]
[ 10050-08-5 ]

Reference： [1] Organometallics, 1999, vol. 18, # 14, p. 2580 - 2582

13
[ 93032-04-3 ]
[ 598-70-9 ]
[ 354-38-1 ]

Reference： [1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1985, vol. 34, # 5, p. 1089 - 1091[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1985, # 5, p. 1190 - 1192

14
[ 84353-59-3 ]
[ 354-38-1 ]
[ 84353-56-0 ]

Reference： [1] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 9, p. 3374 - 3376

15
[ 84353-55-9 ]
[ 354-38-1 ]
[ 84353-56-0 ]

Reference： [1] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 9, p. 3374 - 3376

16
[ 79-14-1 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 33581-77-0 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

17
[ 849585-22-4 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 17596-96-2 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

18
[ 110-94-1 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55494-07-0 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

19
[ 124-04-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 18105-31-2 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

20
[ 111-14-8 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 25435-96-5 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

21
[ 124-07-2 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

22
[ 141-82-2 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 18457-04-0 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

23
[ 112-05-0 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

24
[ 110-15-6 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 40309-57-7 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

25
[ 100145-14-0 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

26
[ 28664-02-0 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

27
[ 144-62-7 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 18294-04-7 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

28
[ 25561-30-2 ]
[ 99-94-5 ]
[ 354-38-1 ]
[ 53358-36-4 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

29
[ 25561-30-2 ]
[ 110-16-7 ]
[ 354-38-1 ]
[ 23508-82-9 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

30
[ 25561-30-2 ]
[ 65-85-0 ]
[ 354-38-1 ]
[ 2078-12-8 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

31
[ 25561-30-2 ]
[ 142-62-1 ]
[ 354-38-1 ]
[ 14246-15-2 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

32
[ 431-47-0 ]
[ 354-38-1 ]

Reference： [1] Journal of Agricultural and Food Chemistry, 2009, vol. 57, # 18, p. 8303 - 8307

33
[ 844-40-6 ]
[ 354-38-1 ]

Reference： [1] Tetrahedron Letters, 1984, vol. 25, # 35, p. 3909 - 3912

34
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 141-46-8 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

35
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 298-12-4 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

36
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 116-09-6 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

37
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 127-17-3 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

38
[ 692-29-5 ]
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

39
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 100-83-4 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

40
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 56-82-6 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

41
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 4426-12-4 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

42
[ 473-68-7 ]
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

43
[ 132619-41-1 ]
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

44
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

45
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 227183-62-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

46
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

47
[ 99265-61-9 ]
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

48
[ 473-90-5 ]
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

49
[ 328-42-7 ]
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

50
[ 542-05-2 ]
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

51
[ 328-50-7 ]
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

52
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

53
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

54
[ 72915-12-9 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

55
[ 407-25-0 ]
[ 354-38-1 ]

Reference： [1] Chemistry of Materials, 2010, vol. 22, # 9, p. 2962 - 2969
[2] Russian Chemical Bulletin, 2012, vol. 61, # 11, p. 2149 - 2162[3] Izv. Akad. Nauk, Ser. Khim., 2012, # 11, p. 2132 - 2145,14

56
[ 3888-00-4 ]
[ 354-38-1 ]

Reference： [1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1966, p. 437 - 442[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1966, p. 466 - 472

57
[ 815-07-6 ]
[ 354-38-1 ]

Reference： [1] J. Gen. Chem. USSR (Engl. Transl.), 1966, vol. 36, p. 878 - 885[2] Zhurnal Obshchei Khimii, 1966, vol. 36, p. 862 - 871

58
[ 126-81-8 ]
[ 77571-23-4 ]
[ 354-38-1 ]
[ 57857-72-4 ]

Reference： [1] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, p. 777[2] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 4, p. 883 - 884

59
[ 359-45-5 ]
[ 110-83-8 ]
[ 354-38-1 ]
[ 78162-82-0 ]
[ 78162-82-0 ]

Reference： [1] Canadian Journal of Chemistry, 1981, vol. 59, p. 431 - 450

60
[ 144237-33-2 ]
[ 354-38-1 ]

Reference： [1] Journal of Organic Chemistry, 2008, vol. 73, # 12, p. 4398 - 4414

61
[ 1336-21-6 ]
[ 109317-75-1 ]
[ 354-38-1 ]

Reference： [1] Synlett, 2009, # 5, p. 755 - 758

62
[ 3888-00-4 ]
[ 1493-05-6 ]
[ 354-38-1 ]

Reference： [1] Journal of the Chemical Society [Section] C: Organic, 1966, p. 1232 - 1236
[2] , Gmelin Handbook: F: PerFHalOrg.8, 2.4, page 2 - 54,

63
[ 944903-98-4 ]
[ 513-81-5 ]
[ 354-38-1 ]
[ 100696-00-2 ]

Reference： [1] Journal of Fluorine Chemistry, 2007, vol. 128, # 7, p. 740 - 747

64
[ 1868-48-0 ]
[ 513-81-5 ]
[ 354-38-1 ]
[ 100696-00-2 ]

Reference： [1] Journal of Fluorine Chemistry, 2007, vol. 128, # 7, p. 740 - 747

65
[ 55-21-0 ]
[ 75-05-8 ]
[ 381-73-7 ]
[ 359-38-6 ]
[ 354-38-1 ]
[ 100-47-0 ]

Reference： [1] Russian Journal of Organic Chemistry, 2004, vol. 40, # 4, p. 513 - 517

66
[ 55982-15-5 ]
[ 354-38-1 ]

Reference： [1] Chemische Berichte, 1979, vol. 112, p. 1595 - 1605

67
[ 83643-84-9 ]
[ 60-35-5 ]
[ 354-38-1 ]
[ 107638-26-6 ]

Reference： [1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986, vol. 35, p. 1438 - 1442[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986, # 7, p. 1586 - 1592

68
[ 52225-57-7 ]
[ 103-69-5 ]
[ 65797-85-5 ]
[ 677-71-4 ]
[ 354-38-1 ]
[ 106119-57-7 ]

Reference： [1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1989, vol. 38, # 1.2, p. 113 - 119[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1989, vol. 38, # 1, p. 126 - 132

69
[ 407-24-9 ]
[ 60-15-1 ]
[ 354-38-1 ]
[ 331-04-4 ]

Reference： [1] Journal of chromatography, 1973, vol. 78, # 2, p. 273 - 279
[2] , Gmelin Handbook: F: PerFHalOrg.7, 1, page 1 - 84,

70
[ 7632-10-2 ]
[ 407-24-9 ]
[ 354-38-1 ]

Reference： [1] Journal of chromatography, 1973, vol. 78, # 2, p. 273 - 279
[2] , Gmelin Handbook: F: PerFHalOrg.7, 1, page 1 - 84,

71
[ 111-87-5 ]
[ 407-24-9 ]
[ 354-38-1 ]
[ 2561-21-9 ]

Reference： [1] Journal of chromatography, 1973, vol. 78, # 2, p. 273 - 279
[2] , Gmelin Handbook: F: PerFHalOrg.7, 1, page 1 - 84,

72
[ 14565-32-3 ]
[ 2925-25-9 ]
[ 354-38-1 ]
[ 407-24-9 ]

Reference： [1] Journal of Fluorine Chemistry, 1997, vol. 81, # 2, p. 193 - 196

73
[ 1263166-90-0 ]
[ 354-38-1 ]

Reference： [1] Chemistry - A European Journal, 2018, vol. 24, # 34, p. 8535 - 8541

74
[ 141-82-2 ]
[ 25561-30-2 ]
[ 354-38-1 ]
[ 18457-04-0 ]
[ 55982-15-5 ]

Reference： [1] Environmental Science and Technology, 1998, vol. 32, # 16, p. 2357 - 2370

75
[ 354-38-1 ]
[ 70-23-5 ]
[ 133046-46-5 ]

Yield	Reaction Conditions	Operation in experiment
40%	With Lawessons reagent In tetrahydrofuranReflux	A solution of 2,2,2-trifluoroacetamide (14.24 g, 1 eq.) and Lawesson's reagent (30.6 g, 0.6 eq.) in THF (120 mL) was stirred at reflux for 18 hrs. The mixture was cooled, ethyl bromopyruvate (16 mL, 1 eq.) was added and the reaction refluxed for weekend. The reaction was cooled, evaporated in vacuum, and the resulting crude material extracted with dichloromethane and washed with water. The organic layer was dried over Na₂SO₄, filtered, and concentrated to give an orange oil. The oil was purified by chromatography on a silica gel (petroleum ether/dichloromethane) to yield compound 251 in 40percent yield. ¹H NMR- 161 -SDI-18153v₂ (DMSO-J₆, 400 MHz): δ (ppm) 1.32 (t, J= 7.10 Hz, 3H), 4.34 (q, J= 7.10 Hz, 2H), 8.9 (s,IH); 1¹9T NMR (DMSO-J₆, 376 MHz): δ (ppm) -60.29 (s, 3F); MS (ESI, EI⁺): m/z = 225.9(MH⁺).
32%	Stage #1: With Lawessons reagent In tetrahydrofuran for 18 h; Reflux Stage #2: for 18 h; Reflux	A mixture of 2,2,2-trifluoroacetamide (7.12g, 63 mmol) and Lawesson's reagent (15.3 g, 37.8 mmol) in THF (60 mL) was heated at reflux for 18 hours. The reaction was then cooled down to RT and treated with ethyl bromopyruvate (8.0 mL, 63 mmol). The reaction was stirred at reflux for an additional 18 hours, then concentrated under vacuum and diluted with ethyl acetate. This mixture was washed with water (IX) and brine (IX), dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was purified by silica gel chromatography (8X1 1 cm, toluene, then second time with 120g silica gel, hexane/ethyl acetate) to give the title material (4.47g, 32percent) as a pale yellow solid. ¹H NMR (CDCl₃, 400 MHz) δ 8.37 (s, 1H), 4.45 (q, J= 7.0 Hz, 2H), 1.41 (t, J= 7.0 Hz, 1H).

Reference： [1] Patent: WO2011/17389, 2011, A1, . Location in patent: Page/Page column 161-162
[2] Patent: WO2013/163279, 2013, A1, . Location in patent: Paragraph 00141
[3] Patent: US2015/18328, 2015, A1, . Location in patent: Paragraph 1206
[4] Patent: WO2015/3640, 2015, A1, . Location in patent: Page/Page column 265

76
[ 19172-47-5 ]
[ 354-38-1 ]
[ 70-23-5 ]
[ 133046-46-5 ]

Yield	Reaction Conditions	Operation in experiment
21%	Stage #1: for 18 h; Heating / reflux Stage #2: for 18 h; Heating / reflux	A solution of 2,2, 2-trifluoroacetamide (7.12 g, 63 mmol) and Lawesson's Reagent (15.3 g, 37.8 mmol) in THF (anhydrous, 60 ml) was stirred at reflux for 18 h. The reaction mixture was cooled, then ethyl bromopyruvate (8 ml, 63 mmol) added, and refluxed for 18 h. The reaction was cooled, evaporated in vacuo, and the resulting crude material extracted into ethyl acetate and washed with water. The organic fraction was dried over MgSO4, and condensed to givea yellow/orange oil. The residue was purified by flash column chromatography on silica eluting with 15 percent ethyl acetate in hexane to provide the title compound as a clear oil (3 g, 21 percent). 1H NMR (400MHz,CDCI3)8 8.39(1H, s), 4.47 (2H, q, J7. 1), 1.42 (3H, t, J7.2).

Reference： [1] Patent: US2013/289238, 2013, A1, . Location in patent: Page/Page column
[2] Patent: WO2005/49613, 2005, A1, . Location in patent: Page/Page column 50

Same Skeleton Products

Related Products

Historical Records

Related Functional Groups of
[ 354-38-1 ]

Fluorinated Building Blocks

[ 815-06-5 ]

N-Methyl-2,2,2-trifluoroacetamide

Similarity: 0.81

[ 1538-08-5 ]

2,2,2-Trifluoroacetohydrazide

Similarity: 0.78

[ 14719-21-2 ]

2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide

Similarity: 0.68

[ 373-88-6 ]

2,2,2-Trifluoroethanamine hydrochloride

Similarity: 0.59

[ 1171331-39-7 ]

2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride

Similarity: 0.55

Aliphatic Chain Hydrocarbons

[ 815-06-5 ]

N-Methyl-2,2,2-trifluoroacetamide

Similarity: 0.81

[ 1538-08-5 ]

2,2,2-Trifluoroacetohydrazide

Similarity: 0.78

[ 14719-21-2 ]

2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide

Similarity: 0.68

[ 373-88-6 ]

2,2,2-Trifluoroethanamine hydrochloride

Similarity: 0.59

[ 1171331-39-7 ]

2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride

Similarity: 0.55

Amides

[ 815-06-5 ]

N-Methyl-2,2,2-trifluoroacetamide

Similarity: 0.81

[ 1538-08-5 ]

2,2,2-Trifluoroacetohydrazide

Similarity: 0.78

[ 14719-21-2 ]

2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide

Similarity: 0.68

[ 1171331-39-7 ]

2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride

Similarity: 0.55

[ 170655-44-4 ]

2-Chloro-N-(2,2,2-trifluoroethyl)acetamide

Similarity: 0.51

Amines

[ 815-06-5 ]

N-Methyl-2,2,2-trifluoroacetamide

Similarity: 0.81

[ 1538-08-5 ]

2,2,2-Trifluoroacetohydrazide

Similarity: 0.78

[ 14719-21-2 ]

2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide

Similarity: 0.68

[ 373-88-6 ]

2,2,2-Trifluoroethanamine hydrochloride

Similarity: 0.59

[ 1171331-39-7 ]

2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride

Similarity: 0.55

Trifluoromethyls

[ 815-06-5 ]

N-Methyl-2,2,2-trifluoroacetamide

Similarity: 0.81

[ 1538-08-5 ]

2,2,2-Trifluoroacetohydrazide

Similarity: 0.78

[ 14719-21-2 ]

2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide

Similarity: 0.68

[ 373-88-6 ]

2,2,2-Trifluoroethanamine hydrochloride

Similarity: 0.59

[ 1171331-39-7 ]

2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride

Similarity: 0.55

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere