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Chemical Structure| 3534-60-9 Chemical Structure| 3534-60-9

Structure of 3534-60-9

Chemical Structure| 3534-60-9

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Product Details of [ 3534-60-9 ]

CAS No. :3534-60-9
Formula : C11H9NO2
M.W : 187.19
SMILES Code : O=C1C=CC=CN1C2=CC=CC(O)=C2
MDL No. :MFCD24720832

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Application In Synthesis of [ 3534-60-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3534-60-9 ]

[ 3534-60-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3534-60-9 ]
  • [ 1196155-38-0 ]
  • 2-(3-(2-oxopyridin-1(2H)-yl)phenoxy)-6-(trifluoromethyl)isonicotinonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
77% With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 12h; A mixture of <strong>[1196155-38-0]2-chloro-6-(trifluoromethyl)isonicotinonitrile</strong> (200 mg, 0.97 mmol), compound 3 (181 mg, 0.97 mmol), K2C03 (268 mg, 1.94 mmol), and DMF (5 mL), was stirred at RT for 12 h. The mixture was diluted with water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organic extracts were washed with brine (15 mL), dried (Na2S04), filtered and concentrated. The residue was purified (silica gel; eluting 50percent EtOAc/hexanes) to afford compound 4 (220 mg, 77percent) as an off-white solid. 1H MR (400MHz, OMSO-d6): delta 8.23 (s, 1H), 8.05 (s, 1H), 7.58 - 7.67 (m, 2H), 7.50 (m, 1H), 7.33 - 7.41 (m, 3H), 6.49 (m, 1H), 6.33 (m, 1H); LCMS Mass: 357.9 (M++l).
 

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