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Chemical Structure| 353255-15-9 Chemical Structure| 353255-15-9

Structure of 353255-15-9

Chemical Structure| 353255-15-9

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Product Details of [ 353255-15-9 ]

CAS No. :353255-15-9
Formula : C16H18N2O
M.W : 254.33
SMILES Code : O=C(NC1=CC=C(C(C)C)C=C1)C2=CC=CC=C2N
MDL No. :MFCD00277058

Safety of [ 353255-15-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 353255-15-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 353255-15-9 ]

[ 353255-15-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1039948-89-4 ]
  • [ 353255-15-9 ]
  • [ 1235479-96-5 ]
YieldReaction ConditionsOperation in experiment
15.6% With copper dichloride; In ethanol; for 4.0h;Inert atmosphere; Reflux; Example 18. Preparation of 2-(4-(2-hydroxyethoxy)-3,5-dimethyiphenyl)-3-(4- isopropylphenyl)quinazolin-4(3H)-one; [0190] A solution of 1/-/-benzo[d][1 ,3]oxazine-2,4-dione (2.0 g, 12.2 mmol) and 4-isopropylaniline (1.92 ml_, 13.5 mmol) in anhydrous DMF (10 ml_) was stirred at 115C for 6 hours under nitrogen. DMF was removed and the residue was mixed with water (100 ml_) and dichloromethane (150 mL). The organic phase was separated and washed with brine (50 mL). The solvent was removed and the residue was washed with ether (50 mL) to give 2-amino-Lambda/-(4-isopropyl-phenyl)-benzamide as a solid. Yield: 0.80 g (25.8%).[0191] To a solution of 2-amino-Lambda/-(4-isopropylphenyl)benzamide (0.400 g, 1.57 mmol) and <strong>[1039948-89-4]4-(2-hydroxyethoxy)-3,5-dimethylbenzaldehyde</strong> (0.30 g, 1.57 mmol) in anhydrous ethanol (20 mL) was added anhydrous copper (II) chloride (0.63 g, 4.71 mmol). The reaction mixture was stirred at reflux for 4 hours under nitrogen. The solvent was removed and the residue was diluted with dichloromethane (150 mL) and water (100 mL). The organic phase was separated and further washed with water (100 mL), brine (100 mL), and dried over sodium sulfate. The crude mixture was purified by column chromatography on silica gel (230-400 mesh) using hexane/ethyl acetate (1 :1) as eluent to give the title compound as a white solid. Yield: 100 mg (15.6%). MP 160-1620C. 1H-NMR (400 Hz, CDCI3): delta 8.34 (d, J=7.6 Hz1I H), 7.80 (m, 2H), 7.52 (m, 1 H), 7.17 (d, J= 8.4 Hz, 2H), 7.05 (d, J= 8.4 Hz, 2H), 6.97 (s, 2H), 3.90 (m, 2H), 3.78 (t, J= 4.8 Hz, 2H), 2.86 (m, 1 H), 2.13 (s, 6H), 2.06 (t, J=6.4 Hz, 1 H), 1.20 (d, J=7.2 Hz1 3H). MS (ES+) m/z: 429.52 (M+1).
 

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