Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 35253-21-5 Chemical Structure| 35253-21-5

Structure of 35253-21-5

Chemical Structure| 35253-21-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 35253-21-5 ]

CAS No. :35253-21-5
Formula : C9H12ClNO
M.W : 185.65
SMILES Code : NC(C1=CC(Cl)=CC=C1OC)C
InChI Key :NDNZHQUDSYIJBX-UHFFFAOYSA-N
Pubchem ID :4538149

Safety of [ 35253-21-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P501-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405
Class:8
UN#:2735
Packing Group:

Application In Synthesis of [ 35253-21-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35253-21-5 ]

[ 35253-21-5 ] Synthesis Path-Downstream   1~8

YieldReaction ConditionsOperation in experiment
With ammonium chloride; zinc; at 80.0℃; for 5h; General procedure: To a solution of 1 -(3-methoxy-6-(trifluoromethyl)pyridin-2-yl)ethanone oxime (1 .6g, 6.83 mmol)in ethanol (15ml), was added zinc (2.234 g, 34.2 mmol) and ammonium chloride(3.65 g, 68.3 mmol). The resulting mixture was heated to 80 C and stirred for 5h. The reaction concentrated to dryness under reduce pressure. This residue was purified by flash chromatography on silica gel (methanol/ethyl acetate, 1 :5) to afford product 1 -(3-methoxy-6- (trifluoromethyl)pyridin-2-yl)ethanamine ( . g, 4.76 mmol, 69.7 % yield) as a yellow solid. m/z: [M + H]+ Calcd for C9H11 F3N2O322I .I ; Found 221 .2
  • 2
  • [ 35253-21-5 ]
  • [ 236739-02-9 ]
  • [ 903580-79-0 ]
YieldReaction ConditionsOperation in experiment
35% With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 65.0℃; for 24h; iV-(l-(5-Chloro-2-methoxyphenyl)ethyl)-5-fluoro-2-(methylsulfonyl)benzenamine:; 2,4-Difluoro-l-(methylsulfonyl)benzene (0.55 g, 2.9 mmol), l-(5-chloro-2- methoxyphenyl)ethanamine (0.57 g, 2.9 mmol) andΛζiV-diisopropylethylamine (0.77 g, 5.9 mmol) were stirred at 65 0C in dry acetonitrile (20 mL) for 24 h. The solvent was evaporated and the residue was dissolved in dichloromethane and washed with water. The dichloromethane was evaporated and purified by silica chromatography in 20 % ethyl acetate in hexanes to collect the title compound (0.36 mg, 35 % yield). 1H NMR (400 MHz, CDCl3): δ 7.74 (q, IH), 7.18 (m, 2H), 6.84 (d, IH), 6.79 (d, IH), 6.42 (t, IH), 6.17 (d, IH), 4.78 (m, IH), 3.91 (s, 3H), 3.08 (s, 3H), 1.52 (d, 3H).
  • 3
  • [ 6342-64-9 ]
  • [ 35253-21-5 ]
YieldReaction ConditionsOperation in experiment
40% 1 -(5-Chloro-2-methoxyphenyl)ethanamine:; l-(5-Chloro-2-methoxyphenyl)ethanone (6.7 g, 36.3 mmol) and formic acid (1.74 g, 27.7 mmol) were heated in formamide (10 mL) at 170 0C for 20 h. The mixture was cooled to EPO <DP n="51"/>room temperature, diluted with water and extracted with benzene. After removal of benzene by rotary evaporation the crude mixture was heated under reflux conditions in 3 M HCl for 3O h. After cooling, the reaction was added to ether and extracted. The aqueous layer was basified with NaOH to pH 9 and extracted with dichloromethane. The dichloromethane was evaporated to collect the title compound (2.7 g, 40 %). 1H NMR (400 MHz, CDC13): δ 7.39 (d, IH), 7.26 (q, IH), 6.81 (d, IH), 4.62 (m, IH), 3.84 (s, 3H), 1.69 (d, 3H).
  • 4
  • [ 35253-21-5 ]
  • [ 79630-23-2 ]
  • 3-bromo-4-((1-(5-chloro-2-methoxyphenyl)ethyl)amino)benzonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
47.2% With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 140.0℃; for 2h;Microwave irradiation; To a solution of 3-bromo-4-fluorobenzonit le (1 g, 5.00 mmol) and 1 -(5-chloro-2- methoxyphenyl)ethanamine (800 mg, 4.31 mmol) in NMP (10 mL) was added potassium carbonate (1 .382 g, 10.00 mmol) and the resulting mixture was stirred under microwave irradiation at 140 C for 2 h. Following completion of the reaction, the reaction mixture was allowed to cool to rt and water (50 mL) was added. The resulting aqueous mixture was extracted with ethyl acetate (3 x 50 mL). The combined organic layers were then washed with saturated aqueous NaHC03, water, and brine. The washed organic layer was then dried over MgS04, filtered, and concentrated to dryness. The residue obtained was purified by flash chromatography on silica gel (PE/EtOAc = 5/1 ) to provide the desired product 3-bromo-4-((1 - (5-chloro-2-methoxyphenyl)ethyl)amino)benzonitrile (1 g, 2.358 mmol, 47.2% yield) as a yellow solid, m/z: [M + H]+ Calcd for Ci6Hi5BrCIN20 365.0; Found 365.
  • 5
  • [ 35253-21-5 ]
  • 4-((1-(5-chloro-2-methoxyphenyl)ethyl)amino)-3-ethylbenzonitrile [ No CAS ]
  • 6
  • [ 35253-21-5 ]
  • 4-((1-(5-chloro-2-methoxyphenyl)ethyl)amino)-3-ethylbenzoic acid [ No CAS ]
  • 7
  • [ 35253-21-5 ]
  • trans-methyl 4-((4-((1-(5-chloro-2-methoxyphenyl)ethyl)amino)-3-ethylbenzamido)methyl)cyclohexanecarboxylate [ No CAS ]
  • 8
  • [ 35253-21-5 ]
  • trans-4-((4-((1-(5-chloro-2-methoxyphenyl)ethyl)amino)-3-ethylbenzamido)methyl)cyclohexanecarboxylic acid [ No CAS ]
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 35253-21-5 ]

Aryls

Chemical Structure| 903581-03-3

A381436 [903581-03-3]

1-(5-Chloro-2,3-dimethoxyphenyl)ethanamine

Similarity: 0.90

Chemical Structure| 1228571-53-6

A640883 [1228571-53-6]

(R)-2-(1-Aminoethyl)-4-chlorophenol

Similarity: 0.89

Chemical Structure| 1228569-39-8

A349632 [1228569-39-8]

(S)-2-(1-Aminoethyl)-4-chlorophenol

Similarity: 0.89

Chemical Structure| 350480-55-6

A325599 [350480-55-6]

(5-Chloro-2-methoxyphenyl)methanamine hydrochloride

Similarity: 0.87

Chemical Structure| 181473-92-7

A241828 [181473-92-7]

(5-Chloro-2-methoxyphenyl)methanamine

Similarity: 0.87

Chlorides

Chemical Structure| 903581-03-3

A381436 [903581-03-3]

1-(5-Chloro-2,3-dimethoxyphenyl)ethanamine

Similarity: 0.90

Chemical Structure| 1228571-53-6

A640883 [1228571-53-6]

(R)-2-(1-Aminoethyl)-4-chlorophenol

Similarity: 0.89

Chemical Structure| 1228569-39-8

A349632 [1228569-39-8]

(S)-2-(1-Aminoethyl)-4-chlorophenol

Similarity: 0.89

Chemical Structure| 350480-55-6

A325599 [350480-55-6]

(5-Chloro-2-methoxyphenyl)methanamine hydrochloride

Similarity: 0.87

Chemical Structure| 181473-92-7

A241828 [181473-92-7]

(5-Chloro-2-methoxyphenyl)methanamine

Similarity: 0.87

Ethers

Chemical Structure| 903581-03-3

A381436 [903581-03-3]

1-(5-Chloro-2,3-dimethoxyphenyl)ethanamine

Similarity: 0.90

Chemical Structure| 350480-55-6

A325599 [350480-55-6]

(5-Chloro-2-methoxyphenyl)methanamine hydrochloride

Similarity: 0.87

Chemical Structure| 181473-92-7

A241828 [181473-92-7]

(5-Chloro-2-methoxyphenyl)methanamine

Similarity: 0.87

Amines

Chemical Structure| 903581-03-3

A381436 [903581-03-3]

1-(5-Chloro-2,3-dimethoxyphenyl)ethanamine

Similarity: 0.90

Chemical Structure| 1228571-53-6

A640883 [1228571-53-6]

(R)-2-(1-Aminoethyl)-4-chlorophenol

Similarity: 0.89

Chemical Structure| 1228569-39-8

A349632 [1228569-39-8]

(S)-2-(1-Aminoethyl)-4-chlorophenol

Similarity: 0.89

Chemical Structure| 350480-55-6

A325599 [350480-55-6]

(5-Chloro-2-methoxyphenyl)methanamine hydrochloride

Similarity: 0.87

Chemical Structure| 181473-92-7

A241828 [181473-92-7]

(5-Chloro-2-methoxyphenyl)methanamine

Similarity: 0.87