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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
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Inaccessible (Haz class 6.1), International USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 35086-82-9 Chemical Structure| 35086-82-9

Structure of 35086-82-9

Chemical Structure| 35086-82-9

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Product Citations

Product Citations

Agnieszka Gunia-Krzyżak ; Justyna Popiół ; Karolina Słoczyńska ; Dorota Żelaszczyk ; Paulina Koczurkiewicz-Adamczyk ; Katarzyna Wójcik-Pszczoła , et al.

Abstract: Hyperpigmentation disorders may result from inappropriate melanin deposition and/or excessive melanin synthesis. They are classified mainly as aesthetic problems, but they can significantly affect human health by decreasing self-esteem. There are available only limited treatment options for hyperpigmentation disorder, among others, cosmetic products applied topically. Depigmenting ingredients were found to be ineffective and characterized by various side effects. As a result, many efforts are made to discover novel, potent, and safe melanogenesis inhibitors for possible use in topical cosmetic depigmenting formulations. Cinnamic acid derivatives constitute a widely tested group for that purpose. This article reports research in the group of N-alkyl cinnamamide derivatives (un)substituted in phenyl ring. Among tested series, (E)-3-(4-chlorophenyl)-N-(5-hydroxypentyl)acrylamide (compound 21) showed the most promising inhibitory properties in mushroom tyrosinase assay (IC50=36.98±1.07µM for monophenolase activity, IC50=146.71±16.82µM for diphenolase activity) and melanin production inhibition in B16F10 mouse melanoma cell line at concentration 6.25 µM resulting probably from decreasing of Tyr, Mitf, Tyrp-1, and Tyrp-2 genes expression. This compound also showed melanin production inhibitory properties in pigmented reconstructed human epidermis when used in 1% and 2% solutions in 50% PEG400. In vitro evaluation of its safety profile showed no cytotoxicity to human keratinocytes HaCaT, human skin fibroblasts BJ, and human primary epidermal melanocytes HEMa, no mutagenicity in the Ames test, no genotoxicity in micronucleus test, no phototoxicity, as well as no skin irritation potential tested in PEG400 solution. This compound was also shown to penetrate across the epidermis to reach the possible site of action. The performed research led to classify (E)-3-(4-chlorophenyl)-N-(5-hydroxypentyl)acrylamide as a novel potential depigmenting cosmetic ingredient.

Keywords: Cinnamamide ; cinnamic acid derivatives ; hyperpigmentation ; tyrosinase inhibition ; melanogenesis inhibition ; reconstructed human epidermis

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Product Details of [ 35086-82-9 ]

CAS No. :35086-82-9
Formula : C9H6Cl2O
M.W : 201.05
SMILES Code : O=C(Cl)/C=C/C1=CC=CC=C1Cl
MDL No. :MFCD00039311

Safety of [ 35086-82-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501
Class:8
UN#:3261
Packing Group:
 

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