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Chemical Structure| 35019-96-6 Chemical Structure| 35019-96-6

Structure of 35019-96-6

Chemical Structure| 35019-96-6

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Product Details of [ 35019-96-6 ]

CAS No. :35019-96-6
Formula : C10H9NO
M.W : 159.18
SMILES Code : O=C=N[C@@H]1[C@@H](C2=CC=CC=C2)C1

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Application In Synthesis of [ 35019-96-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35019-96-6 ]

[ 35019-96-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3202-33-3 ]
  • [ 35019-96-6 ]
  • 4-phenoxy-N-[(1SR,2RS)-2-phenylcyclopropyl]piperidine-1-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
49% With N-ethyl-N,N-diisopropylamine; In toluene; at 20℃; for 12h; General procedure: To a solution of 4-Phenoxypiperidine (333 mg, 1.88 mmol), N,N?-diisopropylethylamine (320 mul, 1.88 mmol) in toluene (3 ml) was added trans-2-phenylcyclopropyl isocyanate (racemic) (300 mg, 1.88 mmol), and the mixture was stirred for 12 h at room temperature. The reaction mixture was then poured into water and extracted with EtOAc. The organic layer was washed with water and brine, dried over Na2SO4 and filtrated. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (3) (309 mg, 49%) as a white solid.
 

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