349552-70-1|Methyl 1-chloroisoquinoline-3-carboxylate| Ambeed

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Quality Control of [ 349552-70-1 ] Purity: 95% SDS Specification

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Product Details of [ 349552-70-1 ]

CAS No. :	349552-70-1
Formula :	C₁₁H₈ClNO₂
M.W :	221.64
SMILES Code :	COC(=O)C1=CC2=C(C=CC=C2)C(Cl)=N1
MDL No. :	MFCD09863391
InChI Key :	KJBHVFGDDKSFGN-UHFFFAOYSA-N
Pubchem ID :	15531562

Safety of [ 349552-70-1 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 349552-70-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 349552-70-1 ]

[ 349552-70-1 ] Synthesis Path-Downstream 1~35

1
[ 104116-17-8 ]
[ 349552-70-1 ]
[ 349552-74-5 ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

2
[ 69454-42-8 ]
[ 349552-70-1 ]

Yield	Reaction Conditions	Operation in experiment
90%	With trichlorophosphate; In methanol; at 130℃; for 0.166667h;Microwave irradiation;	A mixture of 30 (594 mg, 2.92 mmol) and POCl3 (3 ml, 32.8 mmol) was heated 10 min at 130 C using Biotage Initiator microwave synthesizer. The resulting reaction mixture was dissolved in ethyl acetate (100 ml) and washed with HCl (1 M, 3× 100 ml). The organic phase was dried (Na2SO4) and evaporated to dryness. The crude product was purified by flash chromatography (silica gel) eluting with EtOAc/PE 1:3 to give 31 (585 mg, 90%). 1H NMR (DMSO-d6): δ 8.59 (s, 1H); 8.27 (d, 1H, 3JHH = 8.1 Hz); 8.23 (d, 1H, 3JHH = 7.3 Hz); 7.94 (m, 2H); 3.99 (s, 3H). 13C NMR (DMSO-d6): δ 163.9; 150.1; 139.3; 136.6; 132.0; 131.2; 128.7; 127.1; 125.4; 124.0; 52.2.
87%	With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In toluene; for 5.0h;Reflux;	The mixture of 35 (190 mg, 0.94 mmol),POCl3 (94 μL, 1.03 mmol) and DIPEA (360 μL, 2.07 mmol) in toluene (8 mL) was refluxed for5 h. After cooled down, the mixture was diluted with EtOAc (15 mL) and washed with ice-coldwater, saturated NaHCO3, brine. The organic layer was dried over Na2SO4. The solvent wasremoved under reduced pressure and the residue was purified by silica gel to give 138 mg whitesolid, in 87% yield. 1H NMR (400 MHz, CDCl3) 8.54 (s, 1H), 8.43 (m, 1H), 8.02 (m, 1H),7.887.82 (m, 2H), 4.05 (s, 3H).
87%	With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In toluene; for 5.0h;Reflux;	Themixture of 42 (190 mg, 0.94mmol), POCl3 (94 µL, 1.03 mmol) and DIPEA (360 µL, 2.07 mmol) intoluene (8 mL) was refluxed for 5 h. After cooled down, the mixture was dilutedwith EtOAc (15 mL) and washed with ice-cold water, saturated NaHCO3,brine. The organic layer was dried over Na2SO4. Thesolvent was removed under reduced pressure and the residue was purified bysilica gel to give 138 mg white solid, in 87% yield. 1H NMR (400MHz, CDCl3) d 8.54(s, 1H), 8.43 (m, 1H), 8.02 (m, 1H), 7.88-7.82(m, 2H), 4.05 (s, 3H)

64%

Synthesis of methyl 4-chloroisoquinoline-2-carboxylate: Methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate (0.68g, 3.3mmoles) was dissolved in excess phosphorus oxy chloride (5 mis) and the clear solution heated (950C) for 3 hours and overnight at room temperature. The reaction was diluted with toluene (10mIs) and azeotroped twice. The residual oil was diluted with dichloromethane (10mls) and quenched with ice cooled water (50mIs). Further dichloromethane was added (15mls) and the layers separated. The aqueous layer was extracted with dichloromethane (10mIs) and the dichloromethane phases combined and washed with saturated sodium bicarbonate (10mIs), water (10mIs) and brine (10mIs). After drying over magnesium sulphate the solution was filtered and concentrated to give an off white solid. (0.47g, 64% yield).

References: [1]Bioorganic and Medicinal Chemistry,2011,vol. 19,p. 939 - 950.
[2]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 5045 - 5048.
[3]Bioorganic and Medicinal Chemistry,2015,vol. 23,p. 1701 - 1715.
[4]Tetrahedron,2001,vol. 57,p. 2545 - 2554.
[5]Patent: WO2010/125343,2010,A1 .Location in patent: Page/Page column 37.

3
[ 194027-46-8 ]
[ 349552-70-1 ]
[ 349552-71-2 ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

4
[ 69454-42-8 ]
[ 349552-70-1 ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2002,p. 529 - 532.

5
[ 63586-82-3 ]
[ 349552-70-1 ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2002,p. 529 - 532.

6
[ 23364-15-0 ]
[ 349552-70-1 ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2002,p. 529 - 532.

7
[ 4122-56-9 ]
[ 349552-70-1 ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

8
[ 88590-43-6 ]
[ 349552-70-1 ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

9
[ 119-67-5 ]
[ 349552-70-1 ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

10
[ 349552-70-1 ]
[ 349552-76-7 ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

11
[ 349552-70-1 ]
[ 349552-77-8 ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

12
[ 349552-70-1 ]
[ 349552-75-6 ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

13
[ 349552-70-1 ]
(+)-3-bromomethyl-1-(2-hydroxy-1-naphthyl)isoquinoline [ No CAS ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

14
[ 349552-70-1 ]
[ 349552-73-4 ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

15
[ 349552-70-1 ]
[ 349552-72-3 ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

16
[ 349552-70-1 ]
(+)-3-bromomethyl-1-(3,6-di-tert-butyl-2-hydroxy-1-naphthyl)isoquinoline [ No CAS ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

17
[ 349552-70-1 ]
bis[3-(1-(2-hydroxy-1-naphthyl)isoquinolyl)methyl]sulphide [ No CAS ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

18
[ 349552-70-1 ]
bis[3-(1-(3,6-di-tert-butyl-2-hydroxy-1-naphthyl)isoquinolyl)methyl]sulphide [ No CAS ]

References: [1]Tetrahedron,2001,vol. 57,p. 2545 - 2554.

19
[ 1993-03-9 ]
[ 349552-70-1 ]
[ 1253385-93-1 ]

Yield	Reaction Conditions	Operation in experiment
50%	With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In toluene; at 95℃;Inert atmosphere;	Specific Example of Step 1 Synthesis of methyl 1-(2-fluorophenyl)isoquinoline-3-carboxylate: Methyl 4-chloroisoquinoline-2-carboxylate (0.221g, 1mmole) was dissolved in toluene (10mIs) and 2-fluorophenylboronic acid (0.280mgs, 2mmoles), anhydrous potassium carbonate (0.276g, 2mmoles) and tetrakis (0.060mgs) was added and the vessel flushed with nitrogen. The reaction was heated (950C) overnight and after cooling the reaction was filtered through silica the filtrate was then washed with saturated sodium bicarbonate solution (10mIs), water (10mIs) and then brine (10mIs). After drying over magnesium sulphate and evaporating an off white solid (140mgs, 50% yield, 95% pure was left.

References: [1]Patent: WO2010/125343,2010,A1 .Location in patent: Page/Page column 37; 38.

20
[ 98-16-8 ]
[ 349552-70-1 ]
[ 1268691-06-0 ]

Yield	Reaction Conditions	Operation in experiment
73%	at 150℃; for 0.25h;Microwave irradiation;	A mixture of 31 (200 mg, 0.902 mmol) and 3-trifluoromethylaniline (582 mg, 3.61 mmol) was heated 15 min at 150 C using Biotage Initiator microwave synthesizer. The resulting reaction mixture was dissolved in ethyl acetate (50 ml) and washed with saturated Na2CO3 (2× 50 ml) and H2O (2× 50 ml). The organic phase was dried (Na2SO4) and evaporated to dryness. The crude product was purified by flash chromatography (silica gel) eluting with CH2Cl2 to give 32 (229 mg, 73%). 1H NMR (DMSO-d6): δ 9.62 (s, 1H); 9.03 (s, 1H); 8.69 (d, 1H, 3JHH = 7.2 Hz); 8.31 (d, 1H, 3JHH = 8.2 Hz); 8.06 (s, 1H), 8.03 (m, 1H); 7.79 (m, 2H); 7.54 (t, 1H, 3JHH = 7.9 Hz); 7.31 (d, 1H, 3JHH = 7.7 Hz); 3.94 (s, 3H). 13C NMR (DMSO-d6): δ 166.2; 152.1; 142.3; 139.0; 136.9; 131.1; 129.9 (q, 2JCF = 31.2 Hz); 129.4; 129.1 (2C); 124.9 (q, 1JCF = 272.5 Hz); 123.7; 123.3; 120.4; 118.0 (q, 3JCF = 3.5 Hz); 116.8; 116.5 (q, 3JCF = 3.5 Hz); 52.4. ESI-MS 347.1 (M+H). Anal. Calcd for C18H13F3N2O2: C, 62.43; H, 3.78; N, 8.09. Found: C, 62.35; H, 3.71; N, 8.11.

References: [1]Bioorganic and Medicinal Chemistry,2011,vol. 19,p. 939 - 950.

21
[ 349552-70-1 ]
[ 1268691-07-1 ]

References: [1]Bioorganic and Medicinal Chemistry,2011,vol. 19,p. 939 - 950.

22
[ 349552-70-1 ]
[ 1268691-08-2 ]

References: [1]Bioorganic and Medicinal Chemistry,2011,vol. 19,p. 939 - 950.

23
[ 349552-70-1 ]
[ 1268691-09-3 ]

References: [1]Bioorganic and Medicinal Chemistry,2011,vol. 19,p. 939 - 950.

24
[ 349552-70-1 ]
[ 1443759-13-4 ]

References: [1]Patent: WO2013/87805,2013,A1 .
[2]Patent: US2013/158042,2013,A1 .

25
[ 349552-70-1 ]
[ 1443759-14-5 ]

References: [1]Patent: WO2013/87805,2013,A1 .
[2]Patent: US2013/158042,2013,A1 .

26
[ 349552-70-1 ]
[ 1443759-16-7 ]

References: [1]Patent: WO2013/87805,2013,A1 .
[2]Patent: US2013/158042,2013,A1 .

27
[ 349552-70-1 ]
[ 411235-57-9 ]
[ 1443759-12-3 ]

Yield	Reaction Conditions	Operation in experiment
75%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In 1,4-dioxane; at 110℃; for 12.0h;	Intermediate 14: (l-Cyclopropyl-isoquinolin-3-yl)-(3,3-dimethyl-piperazin-l-yl)-methanone trifluoro acetate 14.1 : l-Cyclopropyl-isoquinoline-3-carboxylic acid methyl ester A mixture of 481 mg (2.17 mmol) l-chloro-isoquinoline-3-carboxylic acid methyl ester, 235 mg (2.74 mmol) cyclopropylboronic acid, 100 mg (0.137 mmol) 1 , l '-bis(diphenyl- phosphino)ferrocenedichloropalladium(II) and 950 mg (4.47 mmol) potassium phosphate in 20 mL dioxane was stirred at 1 10 C for 12 h. The mixture was diluted with EtOAc, filtered over Celite and activated carbon and concentrated in vacuo. The crude material was purified by flash chromatography (PE/EtOAc = 3/1). yield: 370 mg (75 %) ESI-MS: m/z = 228 (M+H)+ Rt(HPLC) : 1.15 min (method 5)
75%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In 1,4-dioxane; at 110℃; for 12.0h;	14.1: 1-Cyclopropyl-isoquinoline-3-carboxylic acid methyl ester A mixture of 481 mg (2.17 mmol) <strong>[349552-70-1]1-chloro-isoquinoline-3-carboxylic acid methyl ester</strong>, 235 mg (2.74 mmol) cyclopropylboronic acid, 100 mg (0.137 mmol) 1,1'-bis(diphenyl-phosphino)ferrocenedichloropalladium(II) and 950 mg (4.47 mmol) potassium phosphate in 20 mL dioxane was stirred at 110 C. for 12 h. The mixture was diluted with EtOAc, filtered over Celite and activated carbon and concentrated in vacuo. The crude material was purified by flash chromatography (PE/EtOAc=3/1). yield: 370 mg (75%) ESI-MS: m/z=228 (M+H)+ Rt(HPLC): 1.15 min (method 5)

References: [1]Patent: WO2013/87805,2013,A1 .Location in patent: Page/Page column 61.
[2]Patent: US2013/158042,2013,A1 .Location in patent: Paragraph 0328; 0329; 03330; 0331; 0332.

28
[ 557-21-1 ]
[ 349552-70-1 ]
[ 1452130-52-7 ]

Yield	Reaction Conditions	Operation in experiment
59%	With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); zinc; In N,N-dimethyl acetamide; at 120℃; for 2.0h;	The mixture of 36 (369 mg, 1.66 mmol),Pd2(dba)3 (73 mg, 0.080 mmol), dppf (88 mg, 0.16 mmol), ZnCN2 (117 mg, 1.0 mmol), and Zn(13 mg, 0.20 mmol) in dimethyl acetamide (4 mL) was heated at 120 C for 2 h. After cooleddown, water (20 mL) was added and the resultant mixture was filtered through celite. The filtratewas extracted with EtOAc (20 mL 3). The combined organic layers were washed with brine,dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel with PE/EA(4/1) to give 207 mg white solid, in 59% yield. 1H NMR (400 MHz, CDCl3) 8.80 (s, 1H), 8.46(m, 1H), 8.11 (m, 1H), 7.987.92 (m, 2H), 4.09 (s, 3H); 13C NMR (100 MHz, CDCl3) δ 164.75,142.02, 135.93, 135.10, 132.60, 132.02, 130.37, 128.76, 127.26, 125.70, 115.04, 53.26.
59%	With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); zinc; In N,N-dimethyl acetamide; at 120℃; for 2.0h;	Themixture of 43 (369 mg, 1.66 mmol),Pd2(dba)3 (73 mg, 0.080 mmol), dppf (88 mg, 0.16 mmol),ZnCN2 (117 mg, 1.0 mmol), and Zn (13 mg, 0.20 mmol) in dimethylacetamide (4 mL) was heated at 120 C for 2 h. After cooled down, water (20 mL)was added and the resultant mixture was filtered through celite. The filtratewas extracted with EtOAc (20 mL 3). The combined organiclayers were washed with brine, dried over Na2SO4,filtered and concentrated. The residue was purified by silica gel with PE/EA(4/1) to give 207 mg white solid, in 59% yield. 1H NMR (400 MHz,CDCl3) d 8.80(s, 1H), 8.46 (m, 1H), 8.11 (m, 1H), 7.98-7.92(m, 2H), 4.09 (s, 3H); 13C NMR (100 MHz, CDCl3) δ 164.75, 142.02, 135.93, 135.10,132.60, 132.02, 130.37, 128.76, 127.26, 125.70, 115.04, 53.26

References: [1]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 5045 - 5048.
[2]Bioorganic and Medicinal Chemistry,2015,vol. 23,p. 1701 - 1715.

29
[ 349552-70-1 ]
[ 1452130-43-6 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 5045 - 5048.
[2]Bioorganic and Medicinal Chemistry,2015,vol. 23,p. 1701 - 1715.

30
[ 349552-70-1 ]
[ 1452130-44-7 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 5045 - 5048.
[2]Bioorganic and Medicinal Chemistry,2015,vol. 23,p. 1701 - 1715.

31
[ 349552-70-1 ]
[ 1452130-45-8 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 5045 - 5048.
[2]Bioorganic and Medicinal Chemistry,2015,vol. 23,p. 1701 - 1715.

32
[ 349552-70-1 ]
[ 1049606-80-5 ]

Yield	Reaction Conditions	Operation in experiment
92%	With sodium hydroxide; In ethanol; for 0.5h;Reflux;	A mixture of 36 (133 mg, 0.6 mmol) in 1NNaOH : EtOH (1 : 1, 6 mL) was refluxed for 0.5 h. After cooled down, the reaction mixture wasconcentrated and adjusted to pH = 3 with 1N HCl. The resultant mixture was dried underreduced pressure. To the residue was added EtOH (20 mL) and refluxed for 5 min. Then it wassubjected to hot filtration. The collected solid was added EtOH (20 mL) and subjected to thesame procedure twice. The combined filtration was concentrated and crystallized withMeOH/Et2O to give 114 mg white solid, in 92% yield. 1H NMR (400 MHz, CD3OD) 8.62 (s,1H), 8.45 (m, 1H), 8.17 (m, 1H), 7.977.91 (m, 2H); 13C NMR (100 MHz, CD3OD) δ 167.21,152.65, 141.76, 138.93, 133.54, 132.39, 130.02, 129.45, 127.40, 125.35.
92%	With sodium hydroxide; In ethanol; water; for 0.5h;Reflux;	A mixture of 43 (133 mg, 0.6 mmol) in 1N NaOH: EtOH (1 : 1, 6 mL) was refluxed for 0.5 h. After cooled down, the reactionmixture was concentrated and adjusted to pH = 3 with 1N HCl. The resultantmixture was dried under reduced pressure. To the residue was added EtOH (20 mL)and refluxed for 5 min. Then it was subjected to hot filtration. The collectedsolid was added EtOH (20 mL) and subjected to the same procedure twice. Thecombined filtration was concentrated and crystallized with MeOH/Et2Oto give 114 mg white solid, in 92% yield. 1H NMR (400 MHz, CD3OD)d 8.62 (s, 1H), 8.45 (m, 1H), 8.17 (m, 1H), 7.97-7.91(m, 2H); 13C NMR (100 MHz, CD3OD) δ 167.21, 152.65, 141.76, 138.93, 133.54, 132.39, 130.02,129.45, 127.40, 125.35

References: [1]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 5045 - 5048.
[2]Bioorganic and Medicinal Chemistry,2015,vol. 23,p. 1701 - 1715.

33
[ 349552-70-1 ]
[ 910123-62-5 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 5045 - 5048.
[2]Bioorganic and Medicinal Chemistry,2015,vol. 23,p. 1701 - 1715.

34
[ 349552-70-1 ]
[ 1452130-51-6 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 5045 - 5048.
[2]Bioorganic and Medicinal Chemistry,2015,vol. 23,p. 1701 - 1715.

35
[ 349552-70-1 ]
17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(1-methylisoquinolin-3-carboxamido)morphinan hydrochloride [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 5045 - 5048.

Historical Records

Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Arndt-Eistert Homologation • Bouveault-Blanc Reduction • Catalytic Hydrogenation • Complex Metal Hydride Reductions • Ester Cleavage • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Hunsdiecker-Borodin Reaction • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Passerini Reaction • Preparation of Amines • Preparation of Carboxylic Acids • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Carboxylic Acids • Reactions with Organometallic Reagents • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Ugi Reaction

Related Functional Groups of
[ 349552-70-1 ]

Chlorides

A392502 [1256353-08-8]

Ethyl 1-chloroisoquinoline-3-carboxylate

Similarity: 0.97

A647105 [1250443-81-2]

Methyl 1-chloro-2,7-naphthyridine-3-carboxylate

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A216298 [6636-55-1]

Methyl 6-chloropicolinate

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A522508 [263881-19-2]

Ethyl 1-chloro-2,7-naphthyridine-3-carboxylate

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A365405 [1049606-80-5]

1-Chloroisoquinoline-3-carboxylic acid

Similarity: 0.92

Esters

A392502 [1256353-08-8]

Ethyl 1-chloroisoquinoline-3-carboxylate

Similarity: 0.97

A647105 [1250443-81-2]

Methyl 1-chloro-2,7-naphthyridine-3-carboxylate

Similarity: 0.95

A216298 [6636-55-1]

Methyl 6-chloropicolinate

Similarity: 0.93

A522508 [263881-19-2]

Ethyl 1-chloro-2,7-naphthyridine-3-carboxylate

Similarity: 0.92

A171425 [1186605-87-7]

Methyl 6-chloro-4-methylpicolinate

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Related Parent Nucleus of
[ 349552-70-1 ]

Isoquinolines

A392502 [1256353-08-8]

Ethyl 1-chloroisoquinoline-3-carboxylate

Similarity: 0.97

A365405 [1049606-80-5]

1-Chloroisoquinoline-3-carboxylic acid

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3-Chloroisoquinoline-1-carboxylic acid

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P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 349552-70-1

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