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Chemical Structure| 347186-01-0 Chemical Structure| 347186-01-0

Structure of 347186-01-0

Chemical Structure| 347186-01-0

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Product Details of [ 347186-01-0 ]

CAS No. :347186-01-0
Formula : C11H22N2O2
M.W : 214.30
SMILES Code : O=C(OC(C)(C)C)NC1CC(N)CCC1
MDL No. :MFCD07367781

Safety of [ 347186-01-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 347186-01-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 347186-01-0 ]

[ 347186-01-0 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 347186-01-0 ]
  • [ 437-86-5 ]
  • trans-tert-butyl (3-((2-methyl-6-nitrophenyl)amino)cyclohexyl)carbamate [ No CAS ]
  • cis-tert-butyl (3-((2-methyl-6-nitrophenyl)amino)cyclohexyl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 130℃; for 6h; To a stirred solution of <strong>[437-86-5]2-fluoro-3-nitrotoluene</strong> (1.3g, 9.34mmol) in DMF (lOmL) was added ri-butyl-3-aminocyclohexylcarbamate (2.4g, 9.34mmol) in DMF (lOmL) and the mixture was heated to 130°C for 6 h. The mixture was then treated DIPEA (1.4g, 11.21mmol) and stirred at room temperature (reaction completion monitored by TLC). The mixture was then diluted with water and extracted with EtOAc (3 x lOOmL). The combined organic layers were washed with brine, dried over anhydrous Na2S04, and concentrated under reduced pressure. The resulting crude was purified by column chromatography to afford trans-tert-butyl (3-((2-methyl-6-nitrophenyl)amino)cyclohexyl) carbamate (1-5) and cis-ieri-butyl (3-((2-methyl-6-nitrophenyl)amino)cyclohexyl) carbamate (1-6). 1-5: ]H-NMR (400 MHz, DMSO-d6): d 7.79 (dd, / = 1.2 and 7.2 Hz, 1H), 7.45 (d, / = 7.6 Hz, 1H), 6.93-6.9 (m, 1H), 6.78 (d, 7 =7.6 Hz, 1H), 6.07 (d, / = 10.4 Hz, 1H), 3.28-3.14 (m, 2H), 2.32 (s, 3H), 1.88-1.63 (m, 4H), 1.35 (s, 9H), 1.26-1.18 (m, 2H), 1.14-0.99 (m, 2H). 1-6: ]H-NMR (400 MHz, DMSO-d6): d 7.82 (t, / = 7.2 Hz, 1H), 7.45 (d, / = 6.8 Hz, 1H), 6.90-6.84 (m, 2H), 6.53 (br s, 1H), 4.54 (s, 1H), 3.66 (br s, 1H), 3.60 (br s, 1H), 2.49 (s, 2H), 2.33 (s, 3H), 1.55-1.35 (m, 6 H), 1.26-1.23 (m, 11 H).
  • 2
  • [ 347186-01-0 ]
  • [ 349-02-0 ]
  • C18H26N4O5 [ No CAS ]
  • 3
  • [ 347186-01-0 ]
  • [ 475216-25-2 ]
  • tert-butyl (3-((4-(methylcarbamoyl)-2-nitrophenyl)amino)cyclohexyl)carbamate [ No CAS ]
 

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