Home Cart Sign in  
Chemical Structure| 34624-38-9 Chemical Structure| 34624-38-9

Structure of 34624-38-9

Chemical Structure| 34624-38-9

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 34624-38-9 ]

CAS No. :34624-38-9
Formula : C9H12N2O2
M.W : 180.20
SMILES Code : O=C(NN)CC1=CC=CC(OC)=C1
MDL No. :MFCD00085106
Boiling Point : No data available
InChI Key :XEALVGVRTCEVES-UHFFFAOYSA-N
Pubchem ID :2774978

Safety of [ 34624-38-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 34624-38-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 34624-38-9 ]

[ 34624-38-9 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 35553-92-5 ]
  • [ 34624-38-9 ]
YieldReaction ConditionsOperation in experiment
95% With hydrazine hydrate monohydrate; In ethanol; for 6h;Reflux; General procedure: Step 2: A mixture of ester (1 equiv) and hydrazine hydrate (4 equiv) in ethanol wasrefluxed for 6 h. After the reaction was finished, the cooled mixture was concentratedin vacuo. The mixture was washed with petroleum ether. The pure crude productwas used without further purification.
1.03 g With hydrazine monohydrate; In ethanol;Reflux; To a solution of 3-methoxyphenylacetic acid (1 g, 6.02 mmol) in ethanol (10 mL) was added cHCl (5 drops) and the mixture heated at reflux overnight. The solvents were evaporated to give the target compound as a white solid. This compound was then dissolved in ethanol (10 mL) and hydrazine hydrate (5.86 mL, 120 mmol) was added and the mixture heated at reflux overnight. Solvents were evaporated and the product was purified by flash chromatography using a gradient mixture of ethyl acetate and hexanes to give the desire compound as a white solid (1.03 g, 94% over 2 steps). 1H NMR (CDCl3), δ 3.79 (s, 3H), 3.83 (s, 2H), 6.83 (m, 4H); MS m/z = 181.5 (M + H)+.
With hydrazine hydrate monohydrate; In ethanol; for 18h;Reflux; General procedure: To a stirred solution of carboxylic acid 11j-r (1 mmol) in EtOH(3 mL) was added conc. HCl (1 drop), and the resulting mixturewas refluxed for 18 h. After cooling, the solvent was removed, andthen the residue was added sat. NaHCO3 aq., and the aqueous mixturewas extracted with CH2Cl2. The organic extracts were driedover Na2SO4, and the solvent was removed to afford the correspondingethyl ester, which was used for the next reaction withoutfurther purification. To a stirred solution of ethyl ester (1 mmol),obtained above, in EtOH (0.5 mL) was added hydrazine monohydrate(0.05 mL, 1 mmol), and the resulting mixture was refluxedfor 18 h. The solvent was removed to give the corresponding acylhydrazide, which was used for the next reaction without furtherpurification. To a stirred solution of acylhydrazide, obtained above,in CH2Cl2 (1 mL) was added a solution of isothiocyanate 8a-h or10c, i (1 mmol) in CH2Cl2 (5 mL), and the resulting mixture was stirredat room temperature for 18 h. The insoluble solid was correctedby filtration, and dried to give acyl hydrazino thiourea 13A-U.
  • 2
  • [ 34624-38-9 ]
  • [ 163266-02-2 ]
  • 1-(5-hydroxy-3-(o-tolyl)-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-(3-methoxyphenyl)ethan-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
7% In isopropyl alcohol; at 90℃; General procedure: A mixture of 2-phenylacetohydrazide (1) (0.10?g, 0.67?mmol) and 1,1,1-trifluoro-5-phenylpentane-2,4-dione (3a) (0.14?g, 0.67?mmol) in a solution of i-PrOH (5?mL) was heated at 90?C for 48?h. After cooling to room temperature, EtOAc and water were added. The EtOAc extract was washed with water, brine and dried (Na2SO4). Flash chromatography (petroleum ether/EtOAc; 100:0 to 93:7) followed by recrystallization from Et2O/petroleum ether gave 4 (0.17?g, 71%), mp 122-123?C (Et2O/petroleum ether).
  • 3
  • [ 53764-99-1 ]
  • [ 34624-38-9 ]
  • 1-(5-hydroxy-3-(m-tolyl)-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-(3-methoxyphenyl)ethan-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
48% In isopropyl alcohol; at 90℃; General procedure: A mixture of 2-phenylacetohydrazide (1) (0.10?g, 0.67?mmol) and 1,1,1-trifluoro-5-phenylpentane-2,4-dione (3a) (0.14?g, 0.67?mmol) in a solution of i-PrOH (5?mL) was heated at 90?C for 48?h. After cooling to room temperature, EtOAc and water were added. The EtOAc extract was washed with water, brine and dried (Na2SO4). Flash chromatography (petroleum ether/EtOAc; 100:0 to 93:7) followed by recrystallization from Et2O/petroleum ether gave 4 (0.17?g, 71%), mp 122-123?C (Et2O/petroleum ether).
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 34624-38-9 ]

Aryls

Chemical Structure| 57676-49-0

A415958 [57676-49-0]

(4-Methoxyphenyl)aceticacid hydrazide

Similarity: 0.98

Chemical Structure| 60075-23-2

A290888 [60075-23-2]

2-(3,4-Dimethoxyphenyl)acetohydrazide

Similarity: 0.94

Chemical Structure| 34547-25-6

A321479 [34547-25-6]

2-(3,4,5-Trimethoxyphenyl)acetohydrazide

Similarity: 0.92

Ethers

Chemical Structure| 57676-49-0

A415958 [57676-49-0]

(4-Methoxyphenyl)aceticacid hydrazide

Similarity: 0.98

Chemical Structure| 60075-23-2

A290888 [60075-23-2]

2-(3,4-Dimethoxyphenyl)acetohydrazide

Similarity: 0.94

Chemical Structure| 34547-25-6

A321479 [34547-25-6]

2-(3,4,5-Trimethoxyphenyl)acetohydrazide

Similarity: 0.92

Amides

Chemical Structure| 57676-49-0

A415958 [57676-49-0]

(4-Methoxyphenyl)aceticacid hydrazide

Similarity: 0.98

Chemical Structure| 60075-23-2

A290888 [60075-23-2]

2-(3,4-Dimethoxyphenyl)acetohydrazide

Similarity: 0.94

Chemical Structure| 34547-25-6

A321479 [34547-25-6]

2-(3,4,5-Trimethoxyphenyl)acetohydrazide

Similarity: 0.92

Hydrazides

Chemical Structure| 57676-49-0

A415958 [57676-49-0]

(4-Methoxyphenyl)aceticacid hydrazide

Similarity: 0.98

Chemical Structure| 60075-23-2

A290888 [60075-23-2]

2-(3,4-Dimethoxyphenyl)acetohydrazide

Similarity: 0.94

Chemical Structure| 34547-25-6

A321479 [34547-25-6]

2-(3,4,5-Trimethoxyphenyl)acetohydrazide

Similarity: 0.92

Amines

Chemical Structure| 57676-49-0

A415958 [57676-49-0]

(4-Methoxyphenyl)aceticacid hydrazide

Similarity: 0.98

Chemical Structure| 60075-23-2

A290888 [60075-23-2]

2-(3,4-Dimethoxyphenyl)acetohydrazide

Similarity: 0.94

Chemical Structure| 34547-25-6

A321479 [34547-25-6]

2-(3,4,5-Trimethoxyphenyl)acetohydrazide

Similarity: 0.92

Chemical Structure| 61904-55-0

A435787 [61904-55-0]

2-(4-Ethoxyphenyl)acetohydrazide

Similarity: 0.92

Hydrazines

Chemical Structure| 57676-49-0

A415958 [57676-49-0]

(4-Methoxyphenyl)aceticacid hydrazide

Similarity: 0.98

Chemical Structure| 60075-23-2

A290888 [60075-23-2]

2-(3,4-Dimethoxyphenyl)acetohydrazide

Similarity: 0.94

Chemical Structure| 34547-25-6

A321479 [34547-25-6]

2-(3,4,5-Trimethoxyphenyl)acetohydrazide

Similarity: 0.92

Chemical Structure| 61904-55-0

A435787 [61904-55-0]

2-(4-Ethoxyphenyl)acetohydrazide

Similarity: 0.92