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Chemical Structure| 3460-29-5 Chemical Structure| 3460-29-5

Structure of 3460-29-5

Chemical Structure| 3460-29-5

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Product Details of [ 3460-29-5 ]

CAS No. :3460-29-5
Formula : C8H10N2O2
M.W : 166.18
SMILES Code : NC1=CC(C)=C([N+]([O-])=O)C=C1C
MDL No. :MFCD00025207
InChI Key :PJAGNJQUIUEGKP-UHFFFAOYSA-N
Pubchem ID :18963

Safety of [ 3460-29-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 3460-29-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3460-29-5 ]

[ 3460-29-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3460-29-5 ]
  • [ 15540-81-5 ]
YieldReaction ConditionsOperation in experiment
76% Part A- Preparation of Copper (1) bromide solution A solution of copper(I) bromide (72.5 g, 505 mmol) in hydrochloric acid, 37% ( 150 mL) was heated to 80 C to obtain a clear solution. Part B- To a mixture of 2,5-dimethyl-4-nitroaniline (21 g, 126 mmol) in cone, hydrochloric acid, ( 1 50 mL), a saturated solution of sodium nitrite ( 1 7.5 g, 253 mmol) in water (20 mL) was added dropwise at 0 C and mixture was stirred for 30 min. After 30 min, above (Part-A) solution of copper (I) bromide (72.5 g, 505 mmol) was added dropwise at 0 C. After complete addition, mixture was heated to 80 C for 1 h. The reaction mixture was di luted with water, extracted with ethyl acetate. The organic layer was dried over anhydrous sodi um sulfate, concentrated under reduced pressure and purified by col umn chromatography (Hexane/EthylAcetate (8:2) to obtain l -bromo-2,5-dimethyl-4-nitrobenzene (22 g, 76 % yield).
 

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