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Chemical Structure| 345927-99-3 Chemical Structure| 345927-99-3

Structure of 345927-99-3

Chemical Structure| 345927-99-3

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Product Details of [ 345927-99-3 ]

CAS No. :345927-99-3
Formula : C16H10ClNO3
M.W : 299.71
SMILES Code : ClC(C1=CC=CC=C1CN2C(C3=CC=CC=C3C2=O)=O)=O

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Application In Synthesis of [ 345927-99-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 345927-99-3 ]

[ 345927-99-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 718632-46-3 ]
  • [ 345927-99-3 ]
  • [ 942273-10-1 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20℃; for 48h; To a suspension of 2-(l,3-dioxo-l,3-dihydro-isoindol-2-ylmethyl)-benzoic acid (1.35 g, 4.8 mmol) in dry dichloromethane (30 mL), at 0 C, under stirring, was added oxalyl chloride (2.1 mL, 24 mmol) and dry N,N-dimethylformamide (35 microL). The mixture was allowed to warm to room temperature, stirred for 1.5 hours then evaporated to dryness. The residue was diluted with dry toluene and evaporated again. The crude acyl chloride thus obtained (yellow solid) was dissolved in dry tetrahydrofuran (20 mL) and treated with N,N-diisopropylethylamine (2.5 mL, 15 mmol) and with a solution of 3- amino-6,6-dimethyl-4H,6H-pyrrolo[3,4-c]pyrazole-2,5-dicarboxylic acid 5-tert-butyl ester 2-ethyl ester (1.3 g, 4 mmol) in 15 mL of dry tetrahydrofuran. The mixture was stirred at room temperature for 2 days then evaporated to dryness. The residue was dissolved in dichloromethane, washed with IN HCl, water, saturated solution of NaHCC>3, brine, dried over sodium sulfate and evaporated to dryness. The crude was purified by flash chromatography on silica gel using dichloromethane/methanol 98.5:1.5 as the eluant affording the title compound as white solid (1.5 g).IH-NMR (400 MHz), delta (ppm, DMSOtZ6): 10.63 (bs, IH), 7.91-7.83 (m, 4H), 7.71 (m, IH), 7.58-7.46 (m, 2H), 7.37 (m, IH), 5.07 (s, 2H), 4.53 (bs, 2H), 4.43 (m, 2H), 1.63 (bs, 6H), 1.50 (s, 9H), 1.37 (m, 3H).
 

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