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Chemical Structure| 34450-18-5 Chemical Structure| 34450-18-5

Structure of 17-ODYA
CAS No.: 34450-18-5

Chemical Structure| 34450-18-5

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LTB ω-hydroxylase inhibitor.

Synonyms: 17-Octadecynoic Acid; Alk-16; Alkynyl Stearic Acid

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Product Citations

Product Citations

Morstein, Johannes ; Shrestha, Rebika ; Van, Que N. ; Lopez, Cesar A. ; Arora, Neha ; Tonelli, Marco , et al.

Abstract: Protein-membrane interactions (PMIs) are ubiquitous in cellular signaling. Initial steps of signal transduction cascades often rely on transient and dynamic interactions with the inner plasma membrane leaflet to populate and regulate signaling hotspots. Methods to target and modulate these interactions could yield attractive tool compounds and drug candidates. Here, the conjugation of a medium-chain lipid tail to the covalent K-Ras(G12C) binder MRTX849 at a solvent-exposed site enables such direct modulation of PMIs. The conjugated lipid tail interacts with the tethered membrane and changes the relative membrane orientation and conformation of K-Ras(G12C), as shown by mol. dynamics (MD) simulation-supported NMR studies. In cells, this PMI modulation restricts the lateral mobility of K-Ras(G12C) and disrupts nanoclusters. The described strategy could be broadly applicable to selectively modulate transient PMIs.

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Product Details of 17-ODYA

CAS No. :34450-18-5
Formula : C18H32O2
M.W : 280.45
SMILES Code : C#CCCCCCCCCCCCCCCCC(O)=O
Synonyms :
17-Octadecynoic Acid; Alk-16; Alkynyl Stearic Acid
MDL No. :MFCD00077382

Safety of 17-ODYA

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
THP-1 macrophages 400 μM 15 hours Tracking fatty acid metabolism and lipid droplet formation PMC4040164

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.57mL

0.71mL

0.36mL

17.83mL

3.57mL

1.78mL

35.66mL

7.13mL

3.57mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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