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Chemical Structure| 343864-78-8 Chemical Structure| 343864-78-8

Structure of 4-Bromo-2-iodonitrobenzene
CAS No.: 343864-78-8

Chemical Structure| 343864-78-8

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Product Details of [ 343864-78-8 ]

CAS No. :343864-78-8
Formula : C6H3BrINO2
M.W : 327.90
SMILES Code : O=[N+](C1=CC=C(Br)C=C1I)[O-]
MDL No. :MFCD18391759
InChI Key :VWDMDPDGACOPSR-UHFFFAOYSA-N
Pubchem ID :12700217

Safety of [ 343864-78-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 343864-78-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 343864-78-8 ]

[ 343864-78-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 343864-78-8 ]
  • [ 1698-16-4 ]
  • 2
  • [ 890042-13-4 ]
  • [ 343864-78-8 ]
  • 2-(5-bromo-2-nitrophenyl)triphenylene [ No CAS ]
YieldReaction ConditionsOperation in experiment
20.2 g With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; for 6h;Reflux; 20.8 g of the <strong>[890042-13-4]2-triphenyleneboronic acid pinacol ester</strong> prepared in Example 1,22 g of 4-iodo-3-nitro-1-bromobenzene,65 g of potassium carbonate and 0.7 g of palladium tetrakistriphenylphosphine were dissolved in 290 ml of a 50% aqueous dioxane solution,After heating and refluxing reaction for about 6 hours, the disappearance of the raw material <strong>[890042-13-4]2-triphenyleneboronic acid pinacol ester</strong> was confirmed by TLC and then cooled to room temperature.The reaction mixture was filtered through diatomaceous earth to remove solid components. To the filtrate was added 200 ml of water, 300 ml of dichloromethane was added, and the mixture was stirred for 30 minutes and then layered. The separated organic layer was washed twice with 200 ml of water, layered, dehydrated with anhydrous magnesium sulfate, and short-columned with silica gel in an appropriate amount. After the filtrate is concentrated under reduced pressure, 120 ml of isopropanol is added to the solution, which is then heated to reflux for 1 hour and then cooled to room temperature to crystallize. The precipitate was filtered, washed with isopropanol and dried to obtain 20.2 g of 2- (5-bromo-2-nitrophenyl) triphenylene as an off-white powder in a purity of 96.98% by liquid chromatography.
 

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