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Chemical Structure| 34234-46-3 Chemical Structure| 34234-46-3

Structure of 34234-46-3

Chemical Structure| 34234-46-3

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Product Details of [ 34234-46-3 ]

CAS No. :34234-46-3
Formula : C9H3F5O2
M.W : 238.11
SMILES Code : O=C(O)/C=C/C1=C(F)C(F)=C(F)C(F)=C1F

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Application In Synthesis of [ 34234-46-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 34234-46-3 ]

[ 34234-46-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 34234-46-3 ]
  • [ 2002-92-8 ]
YieldReaction ConditionsOperation in experiment
96% With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20℃; for 22.0h; 2,3,4,5,6-pentafluorocinnamic acid (10, 2.68 g, 11.3 mmol) was dissolved in ethyl acetate (220 mL) and Pd/C (10%, 270 mg) was added under a hydrogen atmosphere. The reaction mixture was stirred at room temperature for 22 h (TLC: hexane/AcOEt, 80:20, v/v). The solution was filtered through a celite pad and the solvent was evaporated under reduced pressure to afford a 3-pentafluorophenylpropanoic acid (11) as a white solid (2.60 g, 96%). 1H NMR (400 MHz, CDCl3) δ = 2.97 (t, 2H, J = 7.5 Hz, -CH2CO2H), 2.64-2.60 (m, 2H, -CH2-) ppm. 19F NMR (377 MHz, CDCl3) δ = -143.45 to -143.53 (m, 2F), -156.42 (t, 1F, J = 20.9 Hz), -162.16 to -162.30 (m, 2F) ppm. C NMR (101 MHz, CDCl3) δ = 178.12 (s, COOH), 146.54-146.27 (m, C-F), 144.09-143.82 (m, C-F), 141.50-141.13 (m, C-F), 138.99-138.55 (m, C-F), 136.48-136.09 (m, C-F), 113.16-112.75 (m, Car), 32.93 (s, -CH2-), 17.60 (s, -CH2-) ppm.
 

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