340774-26-7|Methyl 2-cyclopropanecarbonyl-3-(dimethylamino)prop-2-enoate| Ambeed

Yield	Reaction Conditions	Operation in experiment
97%	at 80℃; for 1h;	[00479] To methyl 4-methyl-3-oxopentanoate (1.98 ml, 13.87 mmol) was added 1,1- dimethoxy-N,N-dimethylmethanamine (2.21 ml, 16.65 mmol) and the solution was stirred at 80 C for 1 h. The reaction mixture was concentrated in vacuo to afford methyl-2- [(dimethylamino)methylidene]-4-methyl-3-oxopentanoate (2.76 g, 95%) as an orange oil. [00480] Method A: LC-MS m/z = 200.0 [M + H]+; RT = 1.00
	In chloroform; at 60℃;	Example 49: N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-3- [4- (5- cyclopropyl-l-isopropyl-IH-pyrazol-4-yl)- [1, 2,3] triazol-1-yl]-4-methyl-benzamide; 3-Cyclopropyl-3-oxo-propionic acid methyl ester (1.25 g, 8.79 mmol) was dissovled in 6.25 mL of CHC13 and 1.17 mL (8.79 mmol) of dimethylformamide dimethyl acetal was added. The mixture was heated to 60C in a sealed vessel overnight. The mixuture was then cooled and concentrated to provide 1.67 g of 2-cyclopropanecarbonyl-3- dimethylamino-acrylic acid methyl ester.
	In toluene; for 3h;Reflux;	Step 1 Production of methyl 2-cyclopropylcarbonyl-3-dimethylaminoacrylate Methyl 3-cyclopropyl-3-oxopropionate (2.0 g) was dissolved in toluene (20 ml). To the obtained solution was added dimethylformamide dimethylacetal (3.0 ml) and the mixture was refluxed for 3 hr. The reaction mixture was allowed to cool and concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (n-hexane:acetone=2:1) to give the title compound as a yellow oil (2.61 g).

	In toluene; for 3h;Heating / reflux;	Step 1 Production of methyl 2-cyclopropylcarbonyl-3-dimethylaminoacrylate Methyl 3-cyclopropyl-3-oxopropionate (2.0 g) was dissolved in toluene (20 ml). To the obtained solution was added dimethylformamide dimethylacetal (3.0 ml) and the mixture was refluxed for 3 hr. The reaction mixture was allowed to cool and concentrated under reduced pressure, and the obtained residue was purified by silica gel chromatography (n-hexane:acetone=2:1) to give the title compound as a yellow oil (2.61 g).
	In 1,4-dioxane; at 100℃; for 3h;Inert atmosphere;	To a 250 mL round-bottom flask under N2 was added <strong>[32249-35-7]methyl 3-cyclopropyl-3-oxopropanoate</strong> (5.00 g, 35.2 mmol) and dioxane (50 ml). N,N-dimethylformamide dimethyl acetal (4.7 mL, 35 mmol) was added at rt, and the resulting mixture was heated to 100 C for 3 h. The mixture was cooled to rt, concentrated, and used in the next step without purification. MS: 198.1 [M+H]+.
	In 1,4-dioxane; at 100℃; for 3h;Inert atmosphere;	To a 250 mL round-bottom flask under N2 was added <strong>[32249-35-7]methyl 3-cyclopropyl-3-oxopropanoate</strong> (5.00 g, 35.2 mmol) and dioxane (50 ml). N,N-dimethylformamide dimethyl acetal (4.7 mL, 35 mmol) was added at rt, and the resulting mixture was heated to 100 C for 3 h. The mixture was cooled to rt, concentrated, and used in the next step without purification. MS: 198.1 [M+H]+.

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P370 + P378	In case of fire:
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Storage
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P401
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Disposal
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P501	Dispose of contents/container to ...
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Methyl 2-cyclopropanecarbonyl-3-(dimethylamino)prop-2-enoate

CAS No.: 340774-26-7

Alternative Products

Product Details of [ 340774-26-7 ]

Safety of [ 340774-26-7 ]

Application In Synthesis of [ 340774-26-7 ]

[ 340774-26-7 ] Synthesis Path-Downstream 1~1

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed