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Chemical Structure| 340-06-7 Chemical Structure| 340-06-7

Structure of 340-06-7

Chemical Structure| 340-06-7

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Product Details of [ 340-06-7 ]

CAS No. :340-06-7
Formula : C8H7F3O
M.W : 176.14
SMILES Code : FC([C@@H](O)C1=CC=CC=C1)(F)F
MDL No. :MFCD00077845
InChI Key :VNOMEAQPOMDWSR-ZETCQYMHSA-N
Pubchem ID :1472401

Safety of [ 340-06-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Computational Chemistry of [ 340-06-7 ] Show Less

Physicochemical Properties

Num. heavy atoms 12
Num. arom. heavy atoms 6
Fraction Csp3 0.25
Num. rotatable bonds 2
Num. H-bond acceptors 4.0
Num. H-bond donors 1.0
Molar Refractivity 37.57
TPSA ?

Topological Polar Surface Area: Calculated from
Ertl P. et al. 2000 J. Med. Chem.

20.23 Ų

Lipophilicity

Log Po/w (iLOGP)?

iLOGP: in-house physics-based method implemented from
Daina A et al. 2014 J. Chem. Inf. Model.

1.74
Log Po/w (XLOGP3)?

XLOGP3: Atomistic and knowledge-based method calculated by
XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry

2.17
Log Po/w (WLOGP)?

WLOGP: Atomistic method implemented from
Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.

3.22
Log Po/w (MLOGP)?

MLOGP: Topological method implemented from
Moriguchi I. et al. 1992 Chem. Pharm. Bull.
Moriguchi I. et al. 1994 Chem. Pharm. Bull.
Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.

2.34
Log Po/w (SILICOS-IT)?

SILICOS-IT: Hybrid fragmental/topological method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

2.38
Consensus Log Po/w?

Consensus Log Po/w: Average of all five predictions

2.37

Water Solubility

Log S (ESOL):?

ESOL: Topological method implemented from
Delaney JS. 2004 J. Chem. Inf. Model.

-2.54
Solubility 0.511 mg/ml ; 0.0029 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble
Log S (Ali)?

Ali: Topological method implemented from
Ali J. et al. 2012 J. Chem. Inf. Model.

-2.23
Solubility 1.04 mg/ml ; 0.00592 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble
Log S (SILICOS-IT)?

SILICOS-IT: Fragmental method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

-2.75
Solubility 0.31 mg/ml ; 0.00176 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble

Pharmacokinetics

GI absorption?

Gatrointestinal absorption: according to the white of the BOILED-Egg

High
BBB permeant?

BBB permeation: according to the yolk of the BOILED-Egg

Yes
P-gp substrate?

P-glycoprotein substrate: SVM model built on 1033 molecules (training set)
and tested on 415 molecules (test set)
10-fold CV: ACC=0.72 / AUC=0.77
External: ACC=0.88 / AUC=0.94

No
CYP1A2 inhibitor?

Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.83 / AUC=0.90
External: ACC=0.84 / AUC=0.91

No
CYP2C19 inhibitor?

Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.80 / AUC=0.86
External: ACC=0.80 / AUC=0.87

No
CYP2C9 inhibitor?

Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set)
and tested on 2075 molecules (test set)
10-fold CV: ACC=0.78 / AUC=0.85
External: ACC=0.71 / AUC=0.81

No
CYP2D6 inhibitor?

Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set)
and tested on 1068 molecules (test set)
10-fold CV: ACC=0.79 / AUC=0.85
External: ACC=0.81 / AUC=0.87

No
CYP3A4 inhibitor?

Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set)
and tested on 2579 molecules (test set)
10-fold CV: ACC=0.77 / AUC=0.85
External: ACC=0.78 / AUC=0.86

No
Log Kp (skin permeation)?

Skin permeation: QSPR model implemented from
Potts RO and Guy RH. 1992 Pharm. Res.

-5.83 cm/s

Druglikeness

Lipinski?

Lipinski (Pfizer) filter: implemented from
Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev.
MW ≤ 500
MLOGP ≤ 4.15
N or O ≤ 10
NH or OH ≤ 5

0.0
Ghose?

Ghose filter: implemented from
Ghose AK. et al. 1999 J. Comb. Chem.
160 ≤ MW ≤ 480
-0.4 ≤ WLOGP ≤ 5.6
40 ≤ MR ≤ 130
20 ≤ atoms ≤ 70

None
Veber?

Veber (GSK) filter: implemented from
Veber DF. et al. 2002 J. Med. Chem.
Rotatable bonds ≤ 10
TPSA ≤ 140

0.0
Egan?

Egan (Pharmacia) filter: implemented from
Egan WJ. et al. 2000 J. Med. Chem.
WLOGP ≤ 5.88
TPSA ≤ 131.6

0.0
Muegge?

Muegge (Bayer) filter: implemented from
Muegge I. et al. 2001 J. Med. Chem.
200 ≤ MW ≤ 600
-2 ≤ XLOGP ≤ 5
TPSA ≤ 150
Num. rings ≤ 7
Num. carbon > 4
Num. heteroatoms > 1
Num. rotatable bonds ≤ 15
H-bond acc. ≤ 10
H-bond don. ≤ 5

2.0
Bioavailability Score?

Abbott Bioavailability Score: Probability of F > 10% in rat
implemented from
Martin YC. 2005 J. Med. Chem.

0.55

Medicinal Chemistry

PAINS?

Pan Assay Interference Structures: implemented from
Baell JB. & Holloway GA. 2010 J. Med. Chem.

0.0 alert
Brenk?

Structural Alert: implemented from
Brenk R. et al. 2008 ChemMedChem

0.0 alert: heavy_metal
Leadlikeness?

Leadlikeness: implemented from
Teague SJ. 1999 Angew. Chem. Int. Ed.
250 ≤ MW ≤ 350
XLOGP ≤ 3.5
Num. rotatable bonds ≤ 7

No; 1 violation:MW<1.0
Synthetic accessibility?

Synthetic accessibility score: from 1 (very easy) to 10 (very difficult)
based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties,
trained on 12'782'590 molecules and tested on 40 external molecules (r2 = 0.94)

1.21

Application In Synthesis of [ 340-06-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 340-06-7 ]

[ 340-06-7 ] Synthesis Path-Downstream   1~35

  • 1
  • [ 434-45-7 ]
  • [ 340-06-7 ]
YieldReaction ConditionsOperation in experiment
96% With β-nicotinamide adenine dinucleotide 2’-phosphate reduced tetrasodium salt; D-glucose; Clostridium acetobutylicum alcohol dehydrogenase; In aq. phosphate buffer; dimethyl sulfoxide;pH 8;Enzymatic reaction; A solution of NADPH (21 mg, 0.0287 mmol, 0.01 eq.), D-glucose (3.09 g, 17.2 mmol, 6 eq.),CaADH (50 units) and NADP+-dependent glucose dehydrogenase (2% w/W) in KPO4buffer(100 mM, pH 8.0) and trifluoromethylphenyl ketone (500 mg, 2.87 mmol, in DMSO) was addedso that the final DMSO concentration was 10% (v/v). The reaction mixture was allowed to stir atrt for 8-10 h and reaction progress was monitored by TLC. Product was extracted with ethylacetate and dried over sodium sulfate. Following vacuum filtration and concentration, the crudeproduct was purified by flash column chromatography on silica gel [EtOAc:hexane (1:4)] to givepure alcohol (484 mg, 96%). The ee was determined to be 99.6% (S) by HPLC with a chiralstationary phase (see below).
With NADH; cyclohexanol; In water; at 60℃; for 48h;Microbiological reaction; Enzymatic reaction;Kinetics; Various amounts of heat-treated wet R. rhodochrous cells were suspended in 2mL of 3.7M TFAP and 4.8M cyclohexanol (1:1, v/v ratio). NADH was supplied in an aqueous solution at the start of incubation at 60C. NADH was dissolved with Milli-Q at 250mM. When the final NADH concentration in the reaction mixture was 0.4, 4.0 or 40mM, 3.2, 32 or 320μL water was brought into the 2mL organic media, respectively. After centrifugation, the supernatant was determined using a gas chromatography system (GC-2014, Shimadzu, Kyoto, Japan) with a flame ionization detector. GC analysis was performed with a DB-17 column (30m×0.250mm×0.25μm, J&W Scientific, USA) and nitrogen at 70kPa as the carrier gas. Column temperature was initially kept at 90C for 3min, increased to 240C at a rate of 20C/min and kept at 240C for 3min. Both the injector and detector temperatures were set at 260C. Chiral GC was performed with a MEGA-DEX DMP β column (25m×0.250mm×0.25μm, MEGA S.N.C., Italy) and nitrogen at 70kPa as a carrier gas [30]. Column temperature was initially kept at 130C for 2min, increased to 150C at a rate of 2.5C/min and kept at 150C for 3min.
With D-(+)-glucose; In ethanol; water; at 30℃; for 24h; General procedure: K. marxianus, Hansenula sp., G. candidum, Candida sp., R. rubra, R. minuta, and filamentous fungi, A. niger, Trichoderma harzianum, and M. ramannianus, belong to the collection of the ‘Departamento de Engenharia Bioqumica, Escola de Qumica, UFRJ’. Cells were allowed to grow for 48h at 30C under a shaking speed of 150rpm in the orbital shaker in a medium containing 1% glucose, 0.5% yeast extract, 0.5% peptone, 0.1% (NH4)2SO4, and 0.1% MgSO4·7H2O. After that period, they were harvested by centrifugation, re-suspended in distilled water and used for the reaction. After centrifugation, the cells (12g/L, dried weight) were added to the 250mL Erlenmeyer containing: 5% glucose in a final volume of 50mL distilled water. After 30min of addition of the microorganisms, the substrate (previously dissolved in 1mL of ethanol) was added to the 50mL of the mixture to give a final solution with substrate concentration of 7.2mM or 14.4mM. The reaction was carried out for 24h at 30C under a shaking speed of 150rpm in the orbital shaker. After 24h, the mixture was centrifuged to separate the cells and the liquid phase was extracted with ethyl acetate. The organic phase was dried (anhydrous Na2SO4), filtered, and concentrated under vacuum. Products were analyzed by (chiral) gas chromatography (GC).
References: [1]Journal of the American Chemical Society,1998,vol. 120,p. 13529 - 13530.
[2]Angewandte Chemie - International Edition,2017,vol. 56,p. 771 - 775.
    Angew. Chem.,2017,vol. 129,p. 789 - 793,5.
[3]Chemistry - A European Journal,2017,vol. 23,p. 16843 - 16852.
[4]Chemical Communications,2010,vol. 46,p. 8624 - 8626.
[5]ChemCatChem,2016,vol. 8,p. 3229 - 3233.
[6]ChemCatChem,2019,vol. 11,p. 5800 - 5807.
[7]ACS Catalysis,2020,vol. 10,p. 13794 - 13799.
[8]Synlett,2020,vol. 31,p. 237 - 247.
[9]ACS Catalysis,2018,vol. 8,p. 3525 - 3531.
[10]RSC Advances,2015,vol. 5,p. 22703 - 22711.
[11]Journal of Organic Chemistry,2013,vol. 78,p. 7312 - 7317.
[12]Tetrahedron Letters,1996,vol. 37,p. 5727 - 5730.
[13]Journal of Organic Chemistry,2000,vol. 65,p. 157 - 163.
[14]Tetrahedron Asymmetry,2005,vol. 16,p. 2539 - 2549.
[15]Tetrahedron Asymmetry,2008,vol. 19,p. 2272 - 2275.
[16]Journal of Organic Chemistry,1992,vol. 57,p. 1532 - 1536.
[17]ACS Catalysis,2020,vol. 10,p. 7188 - 7194.
[18]Journal of the American Chemical Society,1956,vol. 78,p. 4374.
[19]Tetrahedron Letters,1996,vol. 37,p. 5727 - 5730.
[20]Tetrahedron Asymmetry,2005,vol. 16,p. 2539 - 2549.
[21]Tetrahedron Letters,2006,vol. 47,p. 4803 - 4806.
[22]Bioscience, Biotechnology and Biochemistry,2006,vol. 70,p. 418 - 426.
[23]Tetrahedron Asymmetry,2008,vol. 19,p. 157 - 159.
[24]Bioscience, Biotechnology and Biochemistry,2011,vol. 75,p. 1055 - 1060.
[25]Biocatalysis and Biotransformation,2011,vol. 29,p. 328 - 336.
[26]Tetrahedron Asymmetry,2011,vol. 22,p. 2172 - 2178.
[27]Process Biochemistry,2013,vol. 48,p. 838 - 843.
[28]Chinese Journal of Chemistry,2013,vol. 31,p. 349 - 354.
[29]Organic and Biomolecular Chemistry,2014,vol. 12,p. 673 - 681.
[30]Tetrahedron,2014,vol. 70,p. 3239 - 3242.
[31]Green Chemistry,2014,vol. 16,p. 4389 - 4400.
[32]Journal of Molecular Catalysis B: Enzymatic,2015,vol. 122,p. 179 - 187.
[33]Chemical Communications,2015,vol. 51,p. 15728 - 15731.
[34]ChemBioChem,2017,vol. 18,p. 253 - 256.
[35]ChemCatChem,2020,vol. 12,p. 2421 - 2425.
[36]European Journal of Inorganic Chemistry,2012,p. 5021 - 5032,12.
  • 2
  • [ 340-06-7 ]
  • [ 58801-07-3 ]
  • [ 58763-62-5 ]
  • 3
  • [ 434-45-7 ]
  • [ 10531-50-7 ]
  • [ 340-06-7 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; hydrogen;[RuCl2(PPh3)((4S)-2-[(Sp)-2-(diphenylphosphino)ferrocenyl]-4-(methylethyl)oxazoline)]; In water; toluene; at 25℃; under 60006.0 Torr; for 16h; C2 (comparison): α,α,α-T rifluoroacetophenone: 0.14 ml (1.0 mmol); catalyst: 4.58 mg(5.0 μmol) of Kcomp; S/C: 200; base: 1.0 ml (1.0 mmol) of 1 M aqueous NaOH; solvent: toluene3 ml; 80 bar of H2/25C; 16 hours. 100% conversion, only 21 % ee.
With 5% Pt/Al2O3; hydrogen; cinchonidine; In toluene; at 20℃; under 2250.23 Torr;Autoclave; The 5 wt.% Pt/Al2O3 catalyst was reduced at elevated temperature in a fixed-bed reactor prior to use. According to the standard procedure, the catalyst was heated under flowing nitrogen up to 400 C in 30 min, followed by a reduction in flowing hydrogen for 60 min at the same temperature, and finally cooled down to room temperature in flowing hydrogen in 30 min. At the end, the freshly reduced catalyst was purged with nitrogen for 10 min and then transferred immediately to the autoclave.The enantioselective hydrogenations of 1 were carried out in a 25-ml stainless steel Parr autoclave equipped with a glass liner with PTFE cover and a magnetic stirrer, and a valve for sample collection or substrate injection. The pressure was controlled with a constant pressure regulator valve (Buchi BPC 9901). Under standard conditions 21 +/- 1 mg of catalyst, 1.85 mmol of substrate and 3.4 μmol of modifier in 5 ml of toluene were stirred magnetically (1000 rpm) at 20 C under a constant hydrogen pressure of 3 bars.Hydrogenation of 2-4 mg (6.8-13.6 μmol) of CD was performed in a 50-ml stainless steel autoclave equipped with a glass liner with PTFE cover and a magnetic stirrer. The pressure was controlled with a constant pressure regulator valve (Buchi BPC 9901). Under standard conditions 42 +/- 2 mg of catalyst, 10 ml of toluene were stirred magnetically (750 rpm) at 25 C under a constant hydrogen pressure of 3 bars. Hydrogenation of CD was followed in the presence of 1 under the same conditions as described earlier for the hydrogenation of CD. 7.4 mmol of 1 was added either before starting the reaction or after a time delay of 30 min in the transient experiments. The standard procedure was applied also for the experiments in the presence of the hydrogenation products of 1. Therein 3.7 mmol of either (R)-2, (S)-2 or 2 has been added to the toluenic solution.The conversion and enantioselectivity in the hydrogenation of 1 were determined by GC analysis, using an HP 6890 gas chromatograph equipped with a capillary column (CP-Chirasil-Dex CB, 25 m × 0.25 mm, i.d. 0.25 μm). Conditions: 80 C for 2 min, 5 C min-1 to 120 C, 120 C for 5 min, 8 C min-1 to 180 C, head pressure 1.5 bar He. Retention times (min): 1 3.60, (S)-2 18.05, (R)-2 18.32. Products were identified by comparison with authentic samples and by GC-MS using an HP 6890 gas chromatograph equipped with an HP 5-MS column (25 m × 0.20 mm, i.d. 0.33 μm) coupled to an HP 5973 mass spectrometer.The identification of the hydrogenated products of CD and the sample preparation is described elsewhere [34] and [35]. The estimated error in the determination of the enantiomeric excess (ee) and the diastereomeric excess (de) was about +/-0.5% (at above 10% conversion) and that of the reaction rate (TOF) was in the range +/-10%.
With formic acid; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; triethylamine; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; at 40℃; for 2.5h; General procedure: The reaction was performed starting with [RuCl2(cymene)]2 (7.3 mg, 0.012 mmol), TsDPEN (11.8 mg, 0.032 mmol) and 2,2,2-trifluoro-1-(4-methoxyphenyl)ethanone (4a) (241 mg, 1.18 mmol) in formic acid/NEt3 (5/2 mol ratio, 3 mL) at 40 C. Full conversion was obtained after 2.5 h. The mixture was diluted with CH2Cl2 (50 mL) and extracted with water (4×25 mL) brine (25 mL) and dried over Na2SO4 The crude product was purified by silica-gel column chromatography (hexane/EtOAc, 8/2, Rf=0.36) and gave 112 mg (0.54 mmol, 46%) of a clear oil,
General procedure: To a solution of chiral lactam alcohol 2 (10.7 mg, 0.04 mmol, 10 mol %) in CHCl3 (0.8 ml) was added a 1 M BH3-THF solution (0.48 ml, 0.48 mmol). The mixture was stirred under Ar at room temperature for 10 min. A solution of trifluoroacetophenone (56 μl, 0.4 mmol) in CHCl3 (0.6 ml) was added dropwise over 1 h using a syringe pump. The reaction mixture was stirred until the ketone disappeared based on TLC (1 h). The reaction was quenched with MeOH (200 μl), extracted with ether and dried over MgSO4. Flash-chromatography of the crude mixture (hexane/AcOEt, 5:1) gave (S)-2,2,2-trifluoro-1-phenylethanol (63.4 mg, 90%). The ee was determined to be 83% by HPLC analysis using a Chiralcel OD column, hexane/i-PrOH = 97:3, 1.0 ml/min, and the absolute configuration was established by comparing the retention time of the commercially available (S)-2,2,2-trifluoro-1-phenylethanol [retention times = 22 and 27 min for (S) and (R), respectively].
General procedure: To a solution of chiral lactam alcohol 2 (10.7 mg, 0.04 mmol, 10 mol %) in CHCl3 (0.8 ml) was added a 1 M BH3-THF solution (0.48 ml, 0.48 mmol). The mixture was stirred under Ar at room temperature for 10 min. A solution of trifluoroacetophenone (56 μl, 0.4 mmol) in CHCl3 (0.6 ml) was added dropwise over 1 h using a syringe pump. The reaction mixture was stirred until the ketone disappeared based on TLC (1 h). The reaction was quenched with MeOH (200 μl), extracted with ether and dried over MgSO4. Flash-chromatography of the crude mixture (hexane/AcOEt, 5:1) gave (S)-2,2,2-trifluoro-1-phenylethanol (63.4 mg, 90%). The ee was determined to be 83% by HPLC analysis using a Chiralcel OD column, hexane/i-PrOH = 97:3, 1.0 ml/min, and the absolute configuration was established by comparing the retention time of the commercially available (S)-2,2,2-trifluoro-1-phenylethanol [retention times = 22 and 27 min for (S) and (R), respectively].
With 5 wt% platinum/alumina; hydrogen; trifluoroacetic acid; (8R,9S)-cinchonine; In toluene; at 0℃; under 7500.75 Torr; 3.5 mmol 4, 48 mg 5 wt.% Pt/Al2O3, 6.8 μmol modifier in 10 mL toluene to which 3 μL trifluoroacetic acid was added, at 0 C and 10 bar.
With aluminum oxide; hydrogen; 8R,9S-cinchoine; platinum; In N,N-dimethyl-formamide; at 20℃; under 750.075 Torr; for 1h; General procedure: enantioselective hydrogenation of 1 was carried out at room temperature and under atmospheric pressure, using a magnetically stirred (750 rpm) 25 ml glass reactor equipped with a rubber septum for sampling, vertical condenser and an entrance for the gas flow. Under standard conditions 3.7 mmol of 1 was dissolved in 5 ml of solvent together with 3.4 mol of CN. Finally, 21±1 mg of the activated catalyst was added to the reaction mixture and the system was flushed with nitrogen at room temperature
With aluminum oxide; hydrogen; 8R,9S-cinchoine; platinum; In toluene; at 20℃; under 750.075 Torr; for 1h; General procedure: enantioselective hydrogenation of 1 was carried out at room temperature and under atmospheric pressure, using a magnetically stirred (750 rpm) 25 ml glass reactor equipped with a rubber septum for sampling, vertical condenser and an entrance for the gas flow. Under standard conditions 3.7 mmol of 1 was dissolved in 5 ml of solvent together with 3.4 mol of CN. Finally, 21±1 mg of the activated catalyst was added to the reaction mixture and the system was flushed with nitrogen at room temperature
With dimethylsulfide borane complex; 2-hydroxy-N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]benzamide; In tetrahydrofuran; at 65℃;Inert atmosphere; General procedure: A 25mL two-necked flask was charged with β-hydroxyamide 1-7 (0.05mmol, 10%) in dry and fresh THF (3mL), equipped with a magnetic stirrer and a connection to the combined nitrogen/vacuum line and closed with a septum. The air in the flask was replaced by nitrogen. β-hydroxyamides 1-7 were dissolved in THF (3mL) with stirring and a solution of BH3·SMe2 (0.5mmol, 10M) complex was added at 0C by a syringe. After the mixture was stirred for 1h at 65C, the freshly distilled ketone (0.5mmol) in freshly dried THF (2mL) was added over a period of 1.5h by a syringe at the same temperature. The reaction mixture was kept stirring at the 65C until the ketone was completely consumed. After stirring for a further 30min at rt, the reaction mixture was quenched by the addition of MeOH (2mL) and extracted with CH2Cl2 three times. The combined organic extracts were washed with brine and dried over MgSO4. After evaporating the solvent under reduced pressure, the product was purified by column chromatography on silica gel using petroleum ether/EtOAc (5:1; for 4′-nitroacetophenone: 5/3) as the eluent. The ee value was determined by HPLC with Chiralcel AS-3 or Chiralcel OD-H columns.
With dimethylsulfide borane complex; 2-hydroxy-N-[(2S)-1-hydroxy-3-methyl-1,1-diphenylbutan-2-yl]benzamide; In tetrahydrofuran; at 65℃;Inert atmosphere; General procedure: A 25mL two-necked flask was charged with β-hydroxyamide 1-7 (0.05mmol, 10%) in dry and fresh THF (3mL), equipped with a magnetic stirrer and a connection to the combined nitrogen/vacuum line and closed with a septum. The air in the flask was replaced by nitrogen. β-hydroxyamides 1-7 were dissolved in THF (3mL) with stirring and a solution of BH3·SMe2 (0.5mmol, 10M) complex was added at 0C by a syringe. After the mixture was stirred for 1h at 65C, the freshly distilled ketone (0.5mmol) in freshly dried THF (2mL) was added over a period of 1.5h by a syringe at the same temperature. The reaction mixture was kept stirring at the 65C until the ketone was completely consumed. After stirring for a further 30min at rt, the reaction mixture was quenched by the addition of MeOH (2mL) and extracted with CH2Cl2 three times. The combined organic extracts were washed with brine and dried over MgSO4. After evaporating the solvent under reduced pressure, the product was purified by column chromatography on silica gel using petroleum ether/EtOAc (5:1; for 4′-nitroacetophenone: 5/3) as the eluent. The ee value was determined by HPLC with Chiralcel AS-3 or Chiralcel OD-H columns.
With D-(+)-glucose; In ethanol; water; at 30℃; for 24h; General procedure: K. marxianus, Hansenula sp., G. candidum, Candida sp., R. rubra, R. minuta, and filamentous fungi, A. niger, Trichoderma harzianum, and M. ramannianus, belong to the collection of the ‘Departamento de Engenharia Bioqumica, Escola de Qumica, UFRJ’. Cells were allowed to grow for 48h at 30C under a shaking speed of 150rpm in the orbital shaker in a medium containing 1% glucose, 0.5% yeast extract, 0.5% peptone, 0.1% (NH4)2SO4, and 0.1% MgSO4·7H2O. After that period, they were harvested by centrifugation, re-suspended in distilled water and used for the reaction. After centrifugation, the cells (12g/L, dried weight) were added to the 250mL Erlenmeyer containing: 5% glucose in a final volume of 50mL distilled water. After 30min of addition of the microorganisms, the substrate (previously dissolved in 1mL of ethanol) was added to the 50mL of the mixture to give a final solution with substrate concentration of 7.2mM or 14.4mM. The reaction was carried out for 24h at 30C under a shaking speed of 150rpm in the orbital shaker. After 24h, the mixture was centrifuged to separate the cells and the liquid phase was extracted with ethyl acetate. The organic phase was dried (anhydrous Na2SO4), filtered, and concentrated under vacuum. Products were analyzed by (chiral) gas chromatography (GC).
With D-(+)-glucose; In ethanol; water; at 30℃; for 24h; General procedure: After the growing process described above, the cells (12g/L, dry weight) were centrifuged and the precipitate was re-suspended in 3mL of distilled water to obtain a cell-suspension. Then, a 1.5% w/v sodium alginate aqueous solution in distilled water (final volume of 20mL) was added to the cell-suspension, and the mixture (cell-suspension and sodium alginate aqueous solution) was dropped into a CaCl2 aqueous solution (0.1M), forming calcium alginate spheres. Spheres were filtered and washed with distilled water. After that, the spheres were added to the 250mL Erlenmeyer containing 50mL of a 5% glucose solution with substrate concentration of 7.2 or 14.4mM (substrates were previously dissolved in 1mL of ethanol before they were added to the 5% glucose solution). The reaction was carried out for 24h at 30C under a shaking speed of 150rpm in the orbital shaker. After 24h, the mixture was filtered to separate the cells and the liquid phase was extracted with ethyl acetate. The organic phase was dried (anhydrous Na2SO4), filtered, and concentrated under vacuum. Products were analyzed by (chiral) gas chromatography (GC).
With Pt/Al2O3; hydrogen; (S)-2-(dibiphenyl-4-ylfluoromethyl)pyrrolidine; In toluene; at 20℃; under 750.075 Torr; for 2h;Sealed tube;Catalytic behavior; General procedure: Hydrogenations of ketones at atmospheric H2-pressure wereperformed in a 50-mL three-necked glass reactor at RT and atatmospheric pressure under constant flow of molecular H2 with a volumetric flow rate of 10 mL min-1 (semi-batch hydrogenation). The third opening of the reactor was sealed with a septum which allowed for addition/removal of solutions containing modifier and ketone by the use of a syringe. The stirring rate was set to 500 rpm. Hydrogenations performed at 10 bar H2-pressure were carried out in a 60-mL Hastelloy steel jacketed-reactor connected to a multi-position valve (VICI) which allows for connecting the reactor to the hydrogen and nitrogen reservoirs, and to open it to the atmosphere.The H2-pressure was controlled with a constant pressure regulator (Brooks 5688 Series). The standard reaction temperature (298 K) in the jacket was controlled with a Haake Phoenix (Thermo) water bath. The stirring rate was set to 750 rpm. The general reaction procedure for all hydrogenations was the following: the pre-reduced catalyst (50 mg Pt/Al2O3) was transferred to the reactor und reduced again in situ in 5 ml solvent under constant H2flow for 1 h. Then, the reaction was initiated by addition of modifier and ketone premixed in 5 mL solvent. The conversion and enantioselectivity in the hydrogenation were determined by gas chromatography (GC), using an Agilent Technologies 7890A gas chromatograph equipped with a flame ionisation detector (FID). Samples were injected with a split ratio of20: 1 at an injector temperature of 250C. For GC separation, a chiral capillary column (CP-Chirasil-Dex CB, 25 m length, 0.25 mm internal diameter, 0.25 m film thickness) was used. For the analysis of KPL hydrogenations, the temperature programme started at 80C, increased to 140C at 10C min-1, increased to 180C at 20C min-1, and then held for 2 min. For the analysis of MBF hydrogenations, the temperature programme started at 120C,increased to 180C at 20C min-1, and then held for 2 min. For the analysis of TFAP hydrogenations, the temperature programmestarted at 120C, held for 1 min, increased to 130C at 1C min-1, held for 1 min, increased to 140C at 10C min-1, held for 1 min,increased to 150C at 1C min-1, held for 1 min, and then increased to 180C at 40C min-1. The FID was operated at 300C with con-stant flows of hydrogen as fuel gas (30 mL min-1) and air as oxidant(400 mL min-1). Nitrogen was used as a make-up gas (25 mL min-1)and helium as a carrier gas (constant flow: 1.623 mL min-1). The target analytes could be separated: KPL (retention time 5.84 min,elution temperature 138.4C, (S)-PL (7.38 min, 167.6C), and (R)-PL (7.51 min, 170.2C); MBF (retention time 6.09 min, elutiontemperature 145.5C, (R)-MM (7.38 min, 155.2C), and (S)-MM(7.51, 155.7C); TFAP (retention time 1.75 min, elution temperature 120.8C, (S)-PTFE (10.7 min, 130.0C), and (R)-PTFE (11.1 min,130.1C). Products were identified using enantiopure alcohol products.
With benzyl[(1R,2R)-2-[(diphenylphosphoroso)amino]-1,2-diphenylethyl]amine; diethylzinc; In hexane; at -20℃; for 48h;Inert atmosphere;Catalytic behavior; General procedure: To a solution of chiral phosphinamide chiral ligand (0.3 mmol) in toluene (1.3 mL), Et2Zn (1.3 mL, 1 M in n-hexane, 1.3 mmol) was added and the resulting mixture was stirred for 10 min at 0 C under an atmosphere of nitrogen. Next, the reaction mixture was cooled to 20 C, and α-trifluoromethyl ketone (1.0 mmol) was added dropwise. After being stirred for 48 h, the reaction was quenched by saturated NH4Cl solution (15 mL) and the mixture was extracted with EtOAc (15 mL 3). The combined organic layer was dried over MgSO4, filtered, and concentrated in vacuo to give a residue, which was purified by flash column chromatography on silica gel (hexane/EtOAc = 10:1) to give the corresponding product.
With bis(1,5-cyclooctadiene)iridium(I) tetrafluoroborate; formic acid; sodium formate; (1R,2R)-N1,N-di(naphthalen-1-yl)cyclohexane-1,2-diamine; In methanol; water; at 70℃; for 22h;Inert atmosphere;Catalytic behavior; General procedure: In a pressure tube, 0.5 mol% of metal precursor [C16H24BF4Ir](2.48 mg, 0.005 mol) and 1 mol% of chiral amine ligand (3.66 mg,0.01 mmol) were dissolved in 2 mL of water and methanol (ratio1:1) and stirred at room temperature for 1 h under argon atmo-sphere. Then formic acid (2.5eq, 0.1 mL), sodium formate (2.5eq,170 mg) and 1eq of ketone substrate (1 mmol) were introduced.The reaction mixture was stirred at 500 rpm and heated at 70C for22 h. After that, the tube was cooled to room temperature; and theorganic compound was extracted with either with ethyl acetate orCH2Cl2, then the solution was dried over Na2SO4, filtrated and con-centrated under reduced pressure. The crude material was purifiedby flash column chromatography on silica gel using cyclohex-ane/ethyl acetate as gradient eluent (90:10-7:3). After evaporation,alcohols were obtained as oil or solid. The products were identifiedby NMR. The conversion and the enantioselectivity were deter-mined by chiral GC or chiral HPLC analysis (Scheme 1).
With dimethylsulfide borane complex; (1R,2S,3R,5R)-2-(1',3',2'-dioxaborolan-2'-yloxy)apopinan-3-amine; In tetrahydrofuran; at 20℃; for 1h; General procedure: To a solution of 1 (0.005-0.01 mmol, 0.5-1 mol %) in dry THF(3 mL) at room temperature, a solution of BH3SMe2 (10 M,100 lL, 1 mmol) in THF (2 mL) was added dropwise at a rate of3.2 mL per hour using a syringe pump. At the same time a solutionof ketone (1 mmol) in THF (2 mL) was also added to the reactionflask at a rate of 3 mL per hour. After the addition of both reagents,the reaction mixture was stirred for 20 min, quenched by the additionof MeOH (1 mL) at room temperature, and stirred for 30 min. Subsequently, the solvents were evaporated under vacuum and theproduct was isolated by column chromatography using hexane/EtOAc (4:1) as the eluent.
With dimethylsulfide borane complex; 3-hydroxy-N-[(1R,2S)-cis-2-hydroxy-2,3-dihydro-1H-inden-1-yl]naphthalene-2-carboxamide; In tetrahydrofuran; at 65℃;Inert atmosphere;Catalytic behavior; General procedure: A 25mL two-necked flask was charged with β-hydroxyamide 1-7 (0.05mmol, 10%) in dry and freshly distilled THF (3mL), equipped with a magnetic stirrer and a connection to a combined nitrogen/vacuum line and closed with a septum. The air in the flask was replaced by nitrogen. β-Hydroxyamides 1-7 were dissolved in THF (3mL) under stirring after which a solution of BH3.SMe2 (0.5mmol, 10M) complex was added at 0C by a syringe. After the mixture was stirred for 1h at 65C, the freshly distilled ketone (0.5mmol) in dry and freshly distilled THF (2mL) was added over a period of 1.5h by syringe at the same temperature. The reaction mixture was stirred at 65C until the ketone was completely consumed. After stirring for a further 30min at rt, the reaction mixture was quenched by the addition of MeOH (2mL) and extracted with CH2Cl2 (3×3mL). The combined organic extracts were washed with brine and dried over MgSO4. After evaporating the solvent under reduced pressure, the product was purified by column chromatography on silica gel using petroleum ether/EtOAc (5:1; for 4′-nitroacetophenone: 5/3) as eluent. The ee value was determined by HPLC with Chiralcel AS-3 or Chiralcel OD-H columns
With dimethylsulfide borane complex; 3-hydroxy-N-[(1S)-2-hydroxy-1-phenylethyl]naphthalene-2-carboxamide; In tetrahydrofuran; at 65℃;Inert atmosphere;Catalytic behavior; General procedure: A 25mL two-necked flask was charged with β-hydroxyamide 1-7 (0.05mmol, 10%) in dry and freshly distilled THF (3mL), equipped with a magnetic stirrer and a connection to a combined nitrogen/vacuum line and closed with a septum. The air in the flask was replaced by nitrogen. β-Hydroxyamides 1-7 were dissolved in THF (3mL) under stirring after which a solution of BH3.SMe2 (0.5mmol, 10M) complex was added at 0C by a syringe. After the mixture was stirred for 1h at 65C, the freshly distilled ketone (0.5mmol) in dry and freshly distilled THF (2mL) was added over a period of 1.5h by syringe at the same temperature. The reaction mixture was stirred at 65C until the ketone was completely consumed. After stirring for a further 30min at rt, the reaction mixture was quenched by the addition of MeOH (2mL) and extracted with CH2Cl2 (3×3mL). The combined organic extracts were washed with brine and dried over MgSO4. After evaporating the solvent under reduced pressure, the product was purified by column chromatography on silica gel using petroleum ether/EtOAc (5:1; for 4′-nitroacetophenone: 5/3) as eluent. The ee value was determined by HPLC with Chiralcel AS-3 or Chiralcel OD-H columns
With tris(triphenylphosphine)ruthenium(II) chloride; (3aR,5R,7R,7aS)-2-(2-(diphenylphosphino)phenyl)-6,6-dimethyl-3a,4,5,6,7,7a-hexahydro-5,7-methanobenzo[d]oxazole; potassium tert-butylate; isopropyl alcohol; for 0.5h;Inert atmosphere; Reflux; General procedure: In a two-neck flask (25 mL), under an inert atmosphere, wereplaced a catalyst solution (0.05 M in isopropanol, 100 lL, 5 lmol),a degassed 0.125 M solution of sodium hydroxide or potassium tert-butoxide in isopropanol (1 mL, 0.125 mmol), and degassed isopropanol(4 mL). After stirring for 15 min. at room temperature acetophenone (120 mg, 1 mmol) was added and the reaction mixture was refluxed for 30 min. Isopropanol was removed on rotary evaporator and 1-phenylethanol was isolated by flash column chromatography on silica gel (eluent: n-hexane:ethyl acetate80:20).
With trimethylamine-N-oxide; C27H18FeO4; hydrogen; In isopropyl alcohol; at 80℃; under 37503.8 Torr; for 22h;Autoclave; General procedure: Under argon atmosphere, the pre-catalyst was dispensed as DCM solution into oven-dried glass tubes fitted in an aluminum block inside a Schlenk tube. After removing DCM under vacuum, a 0.2m solution of Me3NO in iPrOH (0.1mL, 0.002mmol) was dispensed. The resulting mixture was stirred at room temperature for 20min, during which a deep orange color gradually developed. iPrOH (0.3mL) and the substrate (0.2mmol) were added in each vial. Each vial was capped with a Teflon septum pierced by a needle, the block was transferred into the autoclave, and stirring was started. After purging four times with hydrogen, the reaction was pressurized at 50bar and heating was started (80C). The reactions were stirred for 22h under hydrogen pressure at 80C. After cooling down to room temperature, the mixtures were filtered through a short part of celite and then analyzed for conversion and e.e. determination. When needed, product purification was carried out by flash column chromatography (hexane/AcOEt eluent mixtures).
With trimethylamine-N-oxide; C19H26FeO4Si; hydrogen; In isopropyl alcohol; at 80℃; under 37503.8 Torr; for 22h;Autoclave; General procedure: Under argon atmosphere, the pre-catalyst was dispensed as DCM solution into oven-dried glass tubes fitted in an aluminum block inside a Schlenk tube. After removing DCM under vacuum, a 0.2m solution of Me3NO in iPrOH (0.1mL, 0.002mmol) was dispensed. The resulting mixture was stirred at room temperature for 20min, during which a deep orange color gradually developed. iPrOH (0.3mL) and the substrate (0.2mmol) were added in each vial. Each vial was capped with a Teflon septum pierced by a needle, the block was transferred into the autoclave, and stirring was started. After purging four times with hydrogen, the reaction was pressurized at 50bar and heating was started (80C). The reactions were stirred for 22h under hydrogen pressure at 80C. After cooling down to room temperature, the mixtures were filtered through a short part of celite and then analyzed for conversion and e.e. determination. When needed, product purification was carried out by flash column chromatography (hexane/AcOEt eluent mixtures).
With potassium tert-butylate; [((1S,2S)-1-((4R,11bS)-3H-dinaphtho[2,1-c:1',2'-e]phosphepin-4(5H)-yl)-1-phenyl-2-propanamine)Mn(CO)3Br]; isopropyl alcohol; at 50℃; for 14h;Schlenk technique; General procedure: To a solution of ketone (2 mmol) in 2-propanol (19 mL) were added in this order a stock solution of complex 1 in 2-propanol (0.5 mL, 0.02 mol.L-1), and a stock solution of tBuOK in 2-propanol (0.5 mL, 0.04 mol.L-1) at 30 C. The mixture was stirred for 14 h in an oil bath at 30 C. The solution was then filtered through a small pad of silica (4 cm high in a column with a diameter of about 1 cm). The silica was washed with ethyl acetate, volatiles were removed under reduced pressure and the conversion was determined by 1H NMR. The crude reaction mixture was purified by column chromatography (SiO2, a mixture of petroleum ether/ ethyl acetate as eluent) to afford the corresponding alcohol. This latter was analyzed by chiral GC. Enantiomeric excesses were determined by GC analyses performed on a Shimadzu GC-2010 apparatus equipped with a Supelco betaDEX 120 column (30m0.25 mm) using Helium as the vector gas.
With formic acid; C18H23ClN2O2RuS; triethylamine; at 40℃; for 24h; General procedure: A solution of the ruthenium complex (0.015 mmol) in anazeotropic mixture of formic acid/triethylamine (5:2) (1.5 ml) was stirred for 30 min at 40C. The ketone substrate (3.0 mmol) was then added and the reaction was stirred at 40C for 24 h. The reaction was then diluted with DCM (20 ml) and the organic solution washed with sat. NaHCO3(aq) (3x 15 ml). The organic phase was dried over Na2SO4, filtered the dried under reduced pressure.Residual metal-containing residues were removed from the resulting oil by purification through a plug of silica in a pipette eluting with a solvent system of EtOAc/Hexane (1:1). Solvent was removed under reduced pressure then the sample was analysed by chiral GC. GC chiral column: Restek RT-βDEXsm, 30 m x 0.25 mm x 0.25 μm using the methods described earlier.

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  • 4
  • [ 123247-71-2 ]
  • [ 10531-50-7 ]
  • [ 340-06-7 ]
  • 5
  • Chloro-acetic acid 2,2,2-trifluoro-1-phenyl-ethyl ester [ No CAS ]
  • [ 10531-50-7 ]
  • [ 340-06-7 ]
  • 7
  • [ 340-06-7 ]
  • (S)-α-Trifluoromethylbenzylchlorosulfit [ No CAS ]
  • 9
  • [ 340-06-7 ]
  • [ 98-59-9 ]
  • Toluene-4-sulfonic acid (S)-2,2,2-trifluoro-1-phenyl-ethyl ester [ No CAS ]
  • 10
  • (1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (S)-2,2,2-trifluoro-1-phenyl-ethyl ester [ No CAS ]
  • [ 340-06-7 ]
  • 11
  • [ 84194-69-4 ]
  • [ 10531-50-7 ]
  • [ 340-06-7 ]
  • 12
  • [ 340-06-7 ]
  • [ 603-35-0 ]
  • (+)-(S)-<<α-(trifluoromethyl)benzyl>oxy>triphenylphosphonium chloride [ No CAS ]
  • 14
  • 1-benzoyloxy-1-phenyl-2,2,2-trifluoroethane [ No CAS ]
  • [ 340-06-7 ]
  • [ 17659-27-7 ]
  • (R)-2,2,2-trifluoro-1-(phenyl)ethyl benzoate [ No CAS ]
  • 15
  • [ 108-22-5 ]
  • [ 340-05-6 ]
  • [ 84194-69-4 ]
  • [ 340-06-7 ]
  • 16
  • [ 340-05-6 ]
  • [ 97-72-3 ]
  • (S)-2,2,2-trifluoro-1-(phenyl)ethyl isobutyrate [ No CAS ]
  • [ 10531-50-7 ]
  • [ 340-06-7 ]
  • (R)-2,2,2-trifluoro-1-(phenyl)ethyl isobutyrate [ No CAS ]
  • 17
  • [ 340-06-7 ]
  • [ 541515-66-6 ]
  • Dimethyl-bis-((R)-2,2,2-trifluoro-1-phenyl-ethoxy)-silane [ No CAS ]
  • 18
  • [ 340-06-7 ]
  • [ 541513-99-9 ]
  • Dimethyl-((S)-2,2,2-trifluoro-1-phenyl-ethoxy)-((R)-2,2,2-trifluoro-1-phenyl-ethoxy)-silane [ No CAS ]
  • 19
  • [ 340-06-7 ]
  • [ 75-78-5 ]
  • [ 541513-99-9 ]
  • 20
  • [ 108-22-5 ]
  • [ 340-05-6 ]
  • [ 340-06-7 ]
  • [ 84953-55-9 ]
  • (S)-2,2,2-trifluoro-1-phenylethyl acetate [ No CAS ]
  • 21
  • [ 434-45-7 ]
  • [ 1445-91-6 ]
  • [ 10531-50-7 ]
  • [ 340-06-7 ]
  • [ 146801-19-6 ]
  • 22
  • [ 340-06-7 ]
  • [ 407-25-0 ]
  • Trifluoro-acetic acid (S)-2,2,2-trifluoro-1-phenyl-ethyl ester [ No CAS ]
  • 23
  • [ 340-06-7 ]
  • ((S)-sec-Butoxy)-dimethyl-((S)-2,2,2-trifluoro-1-phenyl-ethoxy)-silane [ No CAS ]
  • 24
  • [ 340-06-7 ]
  • ((R)-1,2-Dimethyl-propoxy)-dimethyl-((S)-2,2,2-trifluoro-1-phenyl-ethoxy)-silane [ No CAS ]
  • 25
  • [ 340-06-7 ]
  • [(R)-1-(2-Bromo-phenyl)-ethoxy]-dimethyl-((S)-2,2,2-trifluoro-1-phenyl-ethoxy)-silane [ No CAS ]
  • 26
  • [ 340-06-7 ]
  • Dimethyl-((S)-2,2,2-trifluoro-1-phenyl-ethoxy)-((R)-2,2,2-trifluoro-1-phenyl-ethoxy)-silane [ No CAS ]
  • 27
  • [ 340-06-7 ]
  • ((R)-Indan-1-yloxy)-dimethyl-((S)-2,2,2-trifluoro-1-phenyl-ethoxy)-silane [ No CAS ]
  • 28
  • [ 340-06-7 ]
  • Dimethyl-((S)-2,2,2-trifluoro-1-phenyl-ethoxy)-((1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yloxy)-silane [ No CAS ]
  • 29
  • [ 340-06-7 ]
  • (5R,5aR,8aS,9R)-9-[Dimethyl-((S)-2,2,2-trifluoro-1-phenyl-ethoxy)-silanyloxy]-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one [ No CAS ]
  • 30
  • [ 340-06-7 ]
  • [(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-dimethyl-((S)-2,2,2-trifluoro-1-phenyl-ethoxy)-silane [ No CAS ]
  • 31
  • [ 340-06-7 ]
  • (4E,12E)-(1S,6R,10R,14S,15S,17S,18S,19S)-19-Benzyl-6,15-bis-[dimethyl-((S)-2,2,2-trifluoro-1-phenyl-ethoxy)-silanyloxy]-10,17-dimethyl-16-methylene-2-oxa-20-aza-tricyclo[12.7.0.01,18]henicosa-4,12-diene-3,21-dione [ No CAS ]
  • 32
  • (-)-sparteinePdCl2 [ No CAS ]
  • [ 340-06-7 ]
  • PdCl((+)-α-(trifluoromethyl)benzyl alcoholate)((-)-sparteine) [ No CAS ]
  • 34
  • [ 340-05-6 ]
  • [ 123-62-6 ]
  • [ 1135312-13-8 ]
  • (R)-2,2,2-trifluoro-1-(phenyl)ethyl propionate [ No CAS ]
  • [ 10531-50-7 ]
  • [ 340-06-7 ]
  • 35
  • [ 340-05-6 ]
  • [ 93-97-0 ]
  • [ 10531-50-7 ]
  • [ 340-06-7 ]
  • [ 17659-27-7 ]
  • (R)-2,2,2-trifluoro-1-(phenyl)ethyl benzoate [ No CAS ]
 

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