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Chemical Structure| 3392-09-4 Chemical Structure| 3392-09-4
Chemical Structure| 3392-09-4

Boc-Leu-OSu

CAS No.: 3392-09-4

4.5 *For Research Use Only !

Cat. No.: A458571 Purity: 96%

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Product Details of [ 3392-09-4 ]

CAS No. :3392-09-4
Formula : C15H24N2O6
M.W : 328.36
SMILES Code : O=C(OC(C)(C)C)N[C@H](C(ON1C(CCC1=O)=O)=O)CC(C)C
MDL No. :MFCD00037913
InChI Key :WXRGJQZMGGGTSS-JTQLQIEISA-N
Pubchem ID :11023929

Safety of [ 3392-09-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis [ 3392-09-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3392-09-4 ]

[ 3392-09-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 3392-09-4 ]
  • [ 2002-24-6 ]
  • [ 620594-52-7 ]
  • 2
  • [ 3392-09-4 ]
  • [ 56-40-6 ]
  • [ 32991-17-6 ]
YieldReaction ConditionsOperation in experiment
75.7% With sodium hydrogencarbonate; In 1,4-dioxane; water; REFERENCE EXAMPLE 155 Preparation of Boc-Leu-Gly--OH 2.63 g of H-Gly--OH and 3.50 g of sodium hydrogencarbonate were suspended in 50 ml of water. Thereto was added 50 ml of a dioxane solution containing 10.0 g of Boc-Leu-OSu, and the mixture was stirred for 30 minutes with ice-cooling and then for 15 hours at room temperature. The reaction mixture was concentrated under reduced pressure. The residue was extracted with 70 ml of ethyl acetate. The ethyl acetate layer was washed with 1N hydrochloric acid and a saturated aqueous sodium chloride solution, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-n-hexane to obtain 6.65 g (yield: 75.7%) of the above objective compound having a melting point of 115-123 C.
  • 3
  • [ 3392-09-4 ]
  • ethyl acetate n-hexane [ No CAS ]
  • [ 32991-17-6 ]
YieldReaction ConditionsOperation in experiment
75.7% With sodium bicarbonate; In 1,4-dioxane; water; REFERENCE EXAMPLE 110 Preparation of Boc-Leu-Gly-OH 2.63 Grams of H-Gly-OH and 3.50 g of sodium hydrogen carbonate were suspended in 50 ml of water, to this supension was added, under ice-cooling condition, 50 ml of dioxane solution containing 10.0 g of Boc-Leu-OSu, and stirred for 30 minutes, then this mixture was further stirred at room temperature for 15 hours. The reaction mixture was concentrated under reduced pressure, and the residue thus obtained was extracted with ethyl acetate (70 ml). The ethyl acetate layer was washed with 1N-hydrochloric acid, and with a saturated sodium chloride aqueous solution, then was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue thus obtained was recrystalled from ethyl acetate-n-hexane to obtain 6.65 g (yield: 75.7%) of the above-mentioned objective product. Melting point: 115-123 C.
 

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