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Chemical Structure| 338454-32-3 Chemical Structure| 338454-32-3

Structure of 338454-32-3

Chemical Structure| 338454-32-3

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Product Details of [ 338454-32-3 ]

CAS No. :338454-32-3
Formula : C14H13BrO
M.W : 277.16
SMILES Code : CC1=CC(Br)=CC=C1OCC2=CC=CC=C2
MDL No. :MFCD18361005

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Application In Synthesis of [ 338454-32-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 338454-32-3 ]

[ 338454-32-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 338454-32-3 ]
  • [ 338454-30-1 ]
YieldReaction ConditionsOperation in experiment
65% 4-Bromo-1-benzyloxy-2-methyl-benzene (6.9 g; 25 mmol) is dissolved in tetrahydrofuran (37.5 ml; dried over a molecular sieve) and the solution is cooled to -78 C. A 1.6 M n-butyllithium solution in n-hexane (17 ml; 27.5 mmol) is added dropwise in the course of 30 minutes such that the temperature does not rise above -70 C. After a further 10 minutes at this temperature, trimethyl borate (8.3 ml; 75 mmol) is added dropwise in the course of 25 minutes at below -70 C. The reaction mixture is allowed to warm slowly to room temperature overnight. It is then cooled to 0 C. and an aqueous 1 N hydrochloric acid solution is added dropwise. The reaction mixture is diluted with water and ethyl acetate, the phases are separated and the aqueous phase is re-extracted with ethyl acetate. The combined organic phases are washed successively with water and a saturated aqueous sodium chloride solution, dried over magnesium sulphate, filtered with suction and concentrated. [00235] Yield: 3.95 g (65%) 4-benzyloxy-3-methyl-phenylboron acid as a white powder. [00236] MS(ISN): 301.2 (M-H)-
 

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