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Chemical Structure| 335033-27-7 Chemical Structure| 335033-27-7

Structure of 335033-27-7

Chemical Structure| 335033-27-7

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Product Details of [ 335033-27-7 ]

CAS No. :335033-27-7
Formula : C14H16N2O
M.W : 228.29
SMILES Code : C=CC(N(C)CC(N1C)=CC2=C1C=CC=C2)=O

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Application In Synthesis of [ 335033-27-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 335033-27-7 ]

[ 335033-27-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 709652-82-4 ]
  • [ 335033-27-7 ]
  • [ 709652-81-3 ]
YieldReaction ConditionsOperation in experiment
43% A propionitrile (15 mL) solution of <strong>[709652-82-4]2-amino-5-bromo-nicotinonitrile</strong> (198 mg, 1 mmol), N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-acrylamide (457 mg, 2 mmol) and DIISOPROPYL-ETHYLAMINE (523 UL, 3 mmol) was purged with Argon for 10 min. Pd (OAc) 2 (23 mg, 0.1 mmol) and P (o-Tol) 3 (61 mg, 0.2 mmol) was added and the Argon purge was repeated. The mixture was heated to 100 C and stirred for 6 hr under Argon. Upon cooling, solvents were removed under vacuo and the residue was purified by Flash chromatography (silica, 2% MEOH in CH2CL2). The purified free base was converted to its HCl salt by addition of HCl (1 mL, 1 mmol, 1M in ether). The salt was washed with ether and dried to afford 162 mg (43%) of the title COMPOUND. LH NMR (300 MHz, DMSO-D6) 8 8.50 (m, 2H), 7.55-6. 95 (m, 4H), 6.40 and 6.17 (rotamers, 2s, 1H), 5.03 and 4.83 (rotamers, 2s, 2H), 3.71 and 3.67 (rotamers, 2s, 3H), 3.09 and 2.96 (rotamers, 2s, 3H). MS (ESI) INULE : 346.1662 (M+H) +.
 

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