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Chemical Structure| 334-22-5 Chemical Structure| 334-22-5

Structure of 334-22-5

Chemical Structure| 334-22-5

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Product Details of [ 334-22-5 ]

CAS No. :334-22-5
Formula : C4H9Cl2N
M.W : 142.03
SMILES Code : ClCCNCCCl
MDL No. :MFCD00128968

Safety of [ 334-22-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H315-H314-H227
Precautionary Statements:P210-P260-P264-P270-P280-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P310-P332+P313-P362-P370+P378-P403+P235-P405-P501
Class:8
UN#:1760
Packing Group:

Application In Synthesis of [ 334-22-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 334-22-5 ]

[ 334-22-5 ] Synthesis Path-Downstream   1~1

  • 1
  • 5-amino-1-benzofuran-2-carboxamide [ No CAS ]
  • [ 334-22-5 ]
  • [ 183288-46-2 ]
YieldReaction ConditionsOperation in experiment
5.6 g 5-Amino-l-benzofuran-2-carboxamide (10 g; prepared according to Example 1) was added to N-methyl pyrollidone (50 mL). Bis-2-chloroethylamine (12.2 g) was added to the reaction mixture. The temperature of the reaction mixture was raised to 150C to 155C and the mixture stirred for 2 hours. Tributyl amine (10.5 g) was added to the reaction mixture and stirred at 150C to 155C for 6 hours. The reaction mixture was cooled to 25 C to 30C. Deionized water (350 mL) was added to the reaction mixture and the pH was adjusted to 12 with 20% sodium hydroxide solution (35 mL). The reaction mixture was cooled to 0C to 5C and stirred for 2 hours. The reaction mixture was filtered and washed with water (50 mL). Deionized water (50 mL) was added to the reaction mixture and the pH was adjusted to 4.7 with concentrated hydrochloric acid (3.1 mL). Activated carbon (1 g) was added to the reaction mixture and stirred for 45 minutes. The reaction mixture was filtered and washed with deionized water (50 mL). The pH of the filtrate was adjusted to 12.0 with 20% sodium hydroxide solution (4 mL). The reaction mixture was cooled to 0C to 5C and stirred for 1 hour. The reaction mixture was filtered and washed with deionized water (2 x 10 mL). The solid obtained was dried in air at 50C to 55C to obtain the title compound. Yield: 5.6 g
 

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