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Chemical Structure| 33371-00-5 Chemical Structure| 33371-00-5

Structure of 33371-00-5

Chemical Structure| 33371-00-5

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Product Details of [ 33371-00-5 ]

CAS No. :33371-00-5
Formula : C11H11ClN2O3
M.W : 254.67
SMILES Code : COC1=C(OC)C(OC)=C2N=CN=C(Cl)C2=C1
MDL No. :MFCD09834424

Safety of [ 33371-00-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 33371-00-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 33371-00-5 ]

[ 33371-00-5 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 17413-10-4 ]
  • [ 33371-00-5 ]
  • 4-(3.4-Ethylenedioxybenzyl)amino-6,7,8-trimethoxyquinazoline [ No CAS ]
  • 2
  • [ 52537-00-5 ]
  • [ 33371-00-5 ]
  • 4-(6-Chloro-2,3-dihydro-indol-1-yl)-6,7,8-trimethoxy-quinazoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
20% In isopropyl alcohol; Example 18 4-(6-Chloro-2,3-dihydro-indol-1-yl)-6,7,8-trimethoxy-quinazoline Utilizing a procedure analogous to that described in Example 1, this product was prepared in 20% yield from <strong>[52537-00-5]6-chloro-indoline</strong> (1.1 eq.) and 4-chloro-6,7,8-trimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 139-143 C.; GC/MS: 371 (M+); anal. RP18-HPLC RT: 4.70 min.).
  • 3
  • [ 1029689-82-4 ]
  • [ 33371-00-5 ]
  • methyl 2-(6,7,8-trimethoxyquinazoline-4-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate;sodium iodide; In N,N-dimethyl acetamide; at 160.0℃; for 12.0h; Example 11; <n="71"/>Synthesis of methyl 2-f6.7.8-trimethoxyquinazoline-4-vD- 1.2.3.4- tetrahycroisoquinoline-8-carboxylate; [00214] Methyl 1, 2,3 ,4-tetrahydroisoquinoline-8-carboxy late hydrochloride (268 mg,1.18 mmol), N,N-dimethylacetamide (14.6 mL, 0.158 mol), 4-chloro-6,7,8- trimethoxyquinazoline (300 mg, 1.18 mol), sodium iodide (80 mg, 0.0005 mol), and potassium carbonate (407 mg, 02.94 mol) were combined and heated at 160 0C for 12 hr. The crude product was purified by preparative HPLC with a C 18 column using acetonitrile: water (with 0.1% formic acid) as eluant with a gradient from 10:90 (v/v) to 80:20 (v/v) at a flow rate of 45 mL/min to give methyl 2-(6,7,8-trimethoxyquinazoline-4-yl)- l,2,3,4-tetrahycroisoquinoline-8-carboxylate.
  • 4
  • [ 2613-34-5 ]
  • [ 33371-00-5 ]
  • 6,7,8-trimethoxy N-(3`-chloro-2`,4`-difluorophenyl)-4-aminoquinazoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
70.6% In isopropyl alcohol;Reflux; General procedure: The 4-chloro-6, 7, 8-trimethoxyquinazoline (7) (0.4 mmol) and aromatic amines (0.4 mmol) inisopropyl alcohol (5 mL) were stirred at reflux temperature for about 4 to 24 h and disappearance of 4-chloro-6, 7, 8-trimethoxyquinazoline (7) was monitored by TLC using ethyl acetate and hexanes. TLC tracking to no raw material points (expansion agent: petroleum ether: ethyl acetate = 1:1, V/V), stop the reaction, after cooling, solid precipitated, filtrated, recrystallized and dried to give 6, 7, 8- trimethoxyl-4-anilinoquinazoline (Tg1-14).
 

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Technical Information

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[ 33371-00-5 ]

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Related Parent Nucleus of
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