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Chemical Structure| 3336-58-1 Chemical Structure| 3336-58-1

Structure of Ammonium trifluoroacetate
CAS No.: 3336-58-1

Chemical Structure| 3336-58-1

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Product Details of [ 3336-58-1 ]

CAS No. :3336-58-1
Formula : C2H4F3NO2
M.W : 131.05
SMILES Code : O=C([O-])C(F)(F)F.[NH4+]
MDL No. :MFCD00012615

Safety of [ 3336-58-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P280-P304+P340+P312-P305+P351+P338-P337+P313

Application In Synthesis of [ 3336-58-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3336-58-1 ]

[ 3336-58-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 120871-73-0 ]
  • [ 3336-58-1 ]
  • [ 74739-36-9 ]
  • tert-butyl 4-allyl-3-[(2-nitrophenyl)carbamoyl]-3-[(trifluoroacetyl)amino]-pyrrolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
51% In 2,2,2-trifluoroethanol; at 60℃;Inert atmosphere; Example 46: preparation of (3R,4S)-3-amino-4-(3-boronopropyl)-l-(4- fluorobenzoyl)pyrrolidine-3-carboxylic acidStep 1: tert-Butyl 4-allyl-3-[ (2-nitrophenyl)carbamoyl]-3-[ (trifluoroacetyl) amino] - pyrrolidine- 1-carboxylate[0261] While under nitrogen, a stirred mixture of tert-butyl 3-allyl-4-oxopyrrolidine-l- carboxylate (600 mg, 2.66 mmol), ammonium trifluoroacetate (698 mg, 5.33 mmol) and 2- nitrophenyl isocyanide (690 mg, 4.6 mmol) in 2,2,2-trifluoroethanol (2.7 mL) was placed in a 60 C oil bath and stirred overnight. After cooling to room temperature, the mixture was diluted with ethyl acetate (40 mL), washed with water (3 x 20 mL) and the combined aqueous phase was re-extracted with ethyl acetate (20 mL). The combined organic phase was washed with saturated aqueous sodium chloride (20 mL), dried over Na2S04 and concentrated under reduced pressure. Purification by silica gel chromatography (90 g column, 0-5% ethyl acetate in methylene chloride) gave tert-butyl 4-allyl-3-[(2-nitrophenyl)carbamoyl]-3- [(trifluoroacetyl)amino] -pyrrolidine- 1-carboxylate (665 mg, 51%, 3:2 mixture ofdiastereomers) as an amber gum. LC-MS ESI + MS found for C2iH25F3N406 m/z 509.0 (M + Na). LC-MS ESI" MS found for C2iH25F3N406 m/z 485.1 (M - H).
 

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