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Chemical Structure| 33224-19-0 Chemical Structure| 33224-19-0

Structure of 33224-19-0

Chemical Structure| 33224-19-0

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Product Details of [ 33224-19-0 ]

CAS No. :33224-19-0
Formula : C8H6N2O3
M.W : 178.14
SMILES Code : N#CC1=CC([N+]([O-])=O)=CC(OC)=C1
MDL No. :MFCD00463876

Safety of [ 33224-19-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 33224-19-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 33224-19-0 ]

[ 33224-19-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 33224-19-0 ]
  • [ 269411-71-4 ]
YieldReaction ConditionsOperation in experiment
98.2% With palladium 10% on activated carbon; ammonium acetate; hydrogen In methanol at 40℃; for 8 h; In the three bottle,Dissolve 3-methoxy-5-nitrobenzonitrile (8.0 g, 0.045 mol) in methanol (80 mL) and add 10percent palladium on carbon (1.4 g) and ammonium acetate (6.9 g, 0.090 mol). Hydrogen, reaction at 40 °C for 8 h. Reaction is complete, suction filtration, filter cakeWash with methanol (15 mL x 3). The filtrate was collected and concentrated under reduced pressure. The concentrate was poured into 50 mL of water and extracted with ethyl acetate (40 mL×3).Take, collect the organic phase, dry over anhydrous sodium sulfate, and evaporate the solvent under reduced pressure to obtain 3-amino-5-methoxybenzonitrile as a solid 6.5 g.98.2percent
References: [1] Patent: CN107573264, 2018, A, . Location in patent: Paragraph 0023-0025; 0040-0042; 0057-0059; 0074-0076.
 

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