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Chemical Structure| 33148-82-2 Chemical Structure| 33148-82-2

Structure of 33148-82-2

Chemical Structure| 33148-82-2

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Product Details of [ 33148-82-2 ]

CAS No. :33148-82-2
Formula : C9H10O3S
M.W : 198.24
SMILES Code : O=C(C1=CC=C(C(C)=O)S1)OCC

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Application In Synthesis of [ 33148-82-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 33148-82-2 ]

[ 33148-82-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 33148-82-2 ]
  • [ 62980-03-4 ]
  • [ 4637-24-5 ]
  • [ 1158984-55-4 ]
YieldReaction ConditionsOperation in experiment
72% A solution of ethyl delta-acetyl-thiophene^-carboxylate (0.5g, 2.52mmol) in DMF.DMA (2ml) was heated at 1000C for I hour, then cooled and concentrated under reduced pressure. The solid residue was dissolved in EtOH (20ml). Then 3-trifluoromethylbenzamidine.HCI (Interchim, 0.567g, 2.52mmol) and EtONa (0.206g, 3.03mmol) were added and the mixture <n="34"/>was heated at 800C for 16 hours and then poured into water. After extraction with CH2CI2, the organic phase was dried (Na2SO4) and concentrated under reduced pressure. The residue was purified by chromatography on silica gel (CH2CI2). The title compound was obtained as a white solid (0.69g, yield= 72%). LC/MS (method B): Rt= 4.35mins; MH+ 379.1 ; H1 NMR (300MHz, CDCI3, ppm): 8.86 (d, 1 H), 8.82 (s, 1 H), 8.76 (d, 1 H), 7.85 (d, 1 H), 7.8 (m, 2H), 7.67 (t, 1 H), 7.55 (d, 1 H), 4.42 (q, 2H), 1.45 (t, 3H).
 

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