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Chemical Structure| 330807-44-8 Chemical Structure| 330807-44-8

Structure of 330807-44-8

Chemical Structure| 330807-44-8

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Product Details of [ 330807-44-8 ]

CAS No. :330807-44-8
Formula : C14H19NO4
M.W : 265.31
SMILES Code : O=C(OC)C1=CC=C(C)C(NC(OC(C)(C)C)=O)=C1

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Application In Synthesis of [ 330807-44-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 330807-44-8 ]

[ 330807-44-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 330807-44-8 ]
  • [ 231958-04-6 ]
YieldReaction ConditionsOperation in experiment
74.7% To a stirred solution of 3-tert-butoxycarbonylamino-4-methyl-benzoic acid methyl ester (0.35 g, 1.32 mmol) in 1,4-dioxane (10 mL) was added an aqueous solution of sodium hydroxide (1N, 2.5 mL) and reaction mixture was stirred at room temperature for 12 hours (monitored by silica TLC; ethyl acetate-hexanes, 1:1). Water was distilled off under reduced pressure; obtained crude sodium salt was acidified with acetic acid solution at 0 C. and was extracted with (2*20 mL). Collected organic parts were dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give 3-tert-butoxycarbonylamino-4-methyl-benzoic acid as off white solid, which was taken to the next step without further purification. (Yield 1.20 g, 74.7%).
 

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