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Chemical Structure| 31822-03-4 Chemical Structure| 31822-03-4

Structure of 31822-03-4

Chemical Structure| 31822-03-4

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Product Details of [ 31822-03-4 ]

CAS No. :31822-03-4
Formula : C7H7IN2O
M.W : 262.05
SMILES Code : O=C(NN)C1=CC=CC=C1I
MDL No. :MFCD00025114

Safety of [ 31822-03-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P280-P305+P351+P338-P310

Application In Synthesis of [ 31822-03-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 31822-03-4 ]

[ 31822-03-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 31822-03-4 ]
  • [ 53764-99-1 ]
  • (5-hydroxy-3-(m-tolyl)-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-iodophenyl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
17% In isopropyl alcohol; at 90℃; General procedure: A mixture of 2-phenylacetohydrazide (1) (0.10?g, 0.67?mmol) and 1,1,1-trifluoro-5-phenylpentane-2,4-dione (3a) (0.14?g, 0.67?mmol) in a solution of i-PrOH (5?mL) was heated at 90?C for 48?h. After cooling to room temperature, EtOAc and water were added. The EtOAc extract was washed with water, brine and dried (Na2SO4). Flash chromatography (petroleum ether/EtOAc; 100:0 to 93:7) followed by recrystallization from Et2O/petroleum ether gave 4 (0.17?g, 71%), mp 122-123?C (Et2O/petroleum ether).
  • 2
  • [ 31822-03-4 ]
  • [ 53764-99-1 ]
  • (5-hydroxy-5-(m-tolyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-iodophenyl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% In isopropyl alcohol; at 90℃; General procedure: A mixture of 2-phenylacetohydrazide (1) (0.10?g, 0.67?mmol) and 1,1,1-trifluoro-5-phenylpentane-2,4-dione (3a) (0.14?g, 0.67?mmol) in a solution of i-PrOH (5?mL) was heated at 90?C for 48?h. After cooling to room temperature, EtOAc and water were added. The EtOAc extract was washed with water, brine and dried (Na2SO4). Flash chromatography (petroleum ether/EtOAc; 100:0 to 93:7) followed by recrystallization from Et2O/petroleum ether gave 4 (0.17?g, 71%), mp 122-123?C (Et2O/petroleum ether).
  • 3
  • [ 31822-03-4 ]
  • [ 143982-40-5 ]
  • N'-((imidazo[1,2-a] pyrimidin-2-yl )methylene)-2-iodobenzohydrazide [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% In ethanol; for 5.0h;Reflux; General procedure: To a stirred solution of compound 3 (100 mg, 0.30 mmol) in ethanol was added corresponding benzohydrazides (1.0 mmol) and refluxed for 5 h. The reaction medium was poured into water and extracted with ethyl acetate. The organic layer was washed with water followed by brine solution, dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure, to obtain the pure compounds.
 

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