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Chemical Structure| 314041-39-9 Chemical Structure| 314041-39-9

Structure of 314041-39-9

Chemical Structure| 314041-39-9

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Product Details of [ 314041-39-9 ]

CAS No. :314041-39-9
Formula : C9H7F3O3
M.W : 220.15
SMILES Code : O=C(C1=CC=CC=C1)C(C(F)(F)F)=O.[H]O[H]
MDL No. :MFCD00209621

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Application In Synthesis of [ 314041-39-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 314041-39-9 ]

[ 314041-39-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 314041-39-9 ]
  • [ 69816-37-1 ]
  • [ 69816-39-3 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; In methanol; chloroform; water; To a solution of 1.8 g. of 1-phenyl-3,3,3-trifluoro-1,2-propanedione monohydrate in 40 ml. of methanol, cooled in an ice bath, there was added, with stirring, 2 g. of aminoacetamidine dihydrobromide. Stirring was continued while 8.6 ml. of aqueous 2 N sodium hydroxide was added. The reaction mixture was then stirred at room temperature for about two hours, and then stirred and refluxed for about four hours. The reaction mixture was cooled and acidified with dilute aqueous hydrochloric acid. Water was added, and the mixture extracted with 100 ml. of ethyl acetate. The ethyl acetate extract was dried over anhydrous magnesium sulfate, the drying agent filtered off, and the filtrate concentrated in vacuo. The residue thus obtained was dissolved in chloroform, and chromatographed on a silica gel column using chloroform as the eluant. There was obtained material weighing 100 mg., and identified as 2-amino-5-phenyl-6-trifluoromethylpyrazine.
 

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