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Chemical Structure| 3133-78-6 Chemical Structure| 3133-78-6
Chemical Structure| 3133-78-6

3-Methylbenzo[b]thiophene-2-carboxylic acid

CAS No.: 3133-78-6

4.5 *For Research Use Only !

Cat. No.: A102553 Purity: 98%

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Product Details of [ 3133-78-6 ]

CAS No. :3133-78-6
Formula : C10H8O2S
M.W : 192.23
SMILES Code : CC1=C(SC2=CC=CC=C12)C(O)=O
MDL No. :MFCD01830305
InChI Key :YVKLUKXESFJRCE-UHFFFAOYSA-N
Pubchem ID :821868

Safety of [ 3133-78-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 3133-78-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3133-78-6 ]

[ 3133-78-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3133-78-6 ]
  • [ 1121057-75-7 ]
  • [ 1251537-36-6 ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20℃; Example 5: Tetrahydropyridine 5 was prepared in 2 steps starting with the deprotection of 1 usingMethod 3. The resulting HCl amine salt was dissolved in 7V,7V-dimethylformamide (0.2 M). 3- Methyl-l-benzothiophene-2-carboxylic acid (1.0 equiv) and PyBOP (1.0 equiv) were added followed by the dropwise addition of triethylamine (3.0 equiv). After stirring at room temperature for 30 min, the reaction was diluted with water and filtered. The isolated material was then purified using semi -preparatory liquid chromatography to isolate the fraction of desired boronic acid 5 that resulted from pinacol ester deprotection during the course of the acid coupling. [M-H]- = 300.1 m/z. Activity: B
 

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