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Chemical Structure| 31180-85-5 Chemical Structure| 31180-85-5

Structure of 31180-85-5

Chemical Structure| 31180-85-5

Ethyl 2-(4-oxocyclohexyl)propanoate

CAS No.: 31180-85-5

4.5 *For Research Use Only !

Cat. No.: A817618 Purity: 95%

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Product Details of [ 31180-85-5 ]

CAS No. :31180-85-5
Formula : C11H18O3
M.W : 198.26
SMILES Code : CC(C1CCC(CC1)=O)C(OCC)=O
MDL No. :MFCD27949166

Safety of [ 31180-85-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 31180-85-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 31180-85-5 ]

[ 31180-85-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 661463-17-8 ]
  • [ 31180-85-5 ]
  • ethyl 2-(4-(6-fluoroquinolin-4-yl)-4-hydroxycyclohexyl)propanoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
44% To a solution of <strong>[661463-17-8]4-bromo-6-fluoroquinoline</strong> (163 mg, 0.721 mmol) in THF (5 mL) at -78C was added t-BuLi (1.7M-3.2M in Heptane) (0.849 mL, 1.443 mmol) drop wise. It turned from clear to dark brown color. The reaction was stirred at -78C for 3 min. Then ethyl 2-(4-oxocyclohexyl) propanoate (130 mg, 0.656 mmol) in THF (1 mL) was added drop wise. The reaction was stirred at -78C for lh. The reaction was diluted with saturated NH4C1 and EtOAc. Organic was separated and washed with brine, dried over MgS04, filtered and concentrated to give a crude material. This material was purified with ISCO 40g, 40 mL/min. 0-100% EtOAc/Hexane in 35 min. The desired product was eluted with 55% EtOAc/Hexane to give 234A (100 mg, 0.290 mmol, 44%) as the mixture of the diastereomers.
 

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