Structure of Deferiprone
CAS No.: 30652-11-0
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload. Target: Deferiprone is an orphan drug designed and developed primarily by academic initiatives for the treatment of iron overload in thalassaemia. Deferiprone has been used in several other iron or other metal imbalance conditions and has prospects of wider clinical applications. Deferiprone has high affinity for iron and interacts with almost all the iron pools at the molecular, cellular, tissue and organ levels. Doses of 50-120 mg/kg/day appear to be effective in bringing patients to negative iron balance. Deferiprone increases urinary iron excretion, which mainly depends on the iron load of patients and the dose of the drug.
Synonyms: CGP 37391; DN 18001AF; Ferriprox
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Michel Y. Fares ; Maha A. Hegazy ; Ghada M. El-Sayed ; Maha M. Abdelrahmanc ; Nada S. Abdelwahab ;
Abstract: This work implements a combined experimental approach of analytical quality-by-design (AQbD) and green analytical chemistry (GAC) to develop an HPLC method for simultaneous determination of the two thalassemia drugs, deferasirox (DFX) and deferiprone (DFP), in biological fluid for the first time. This integration was designed to maximize efficiency and minimize environmental impacts, as well as energy and solvent consumption. To accomplish this goal, an analytical quality-by-design approach was performed, beginning with quality risk assessment and scouting analysis, followed by Placket–Burman design screening for five chromatographic parameters. Critical method parameters were thoroughly recognized and then optimized by using a two levels-three factors custom experimental design to evaluate the optimum conditions that achieved the highest resolution with acceptable peak symmetry within the shortest run time. The desirability function was used to define the optimal chromatographic conditions, and the optimal separation was achieved using an XBridge® HPLC RP-C18 (4.6 × 250 mm, 5 μm) column with ethanol : acidic water at pH 3.0 adjusted by phosphoric acid in the ratio of (70 : 30, v/v) as the mobile phase at a flow rate of 1 mL min−1 with UV detection at 225 nm at a temperature of 25 °C. Linearity was obtained over the concentration range of 0.30–20.00 μg mL−1 and 0.20–20.00 μg mL−1 for DFX and DFP, respectively, using 20.00 μg mL−1 ibuprofen (IBF) as an internal standard. The established method's greenness profile was evaluated and measured using various assessment tools, and the developed method was green. For the validation of the developed method, FDA recommendations were followed, and all the results obtained met the acceptance criteria. The suggested method was successfully used to study the pharmacokinetic parameters of DFX and DFP in rat plasma. Due to the substantial increase in bioavailability of the two iron chelating drugs, the results from this study strongly recommend their co-administration.
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CAS No. : | 30652-11-0 |
Formula : | C7H9NO2 |
M.W : | 139.15 |
SMILES Code : | O=C1C(O)=C(C)N(C)C=C1 |
Synonyms : |
CGP 37391; DN 18001AF; Ferriprox
|
MDL No. : | MFCD00134497 |
InChI Key : | TZXKOCQBRNJULO-UHFFFAOYSA-N |
Pubchem ID : | 2972 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02173951 | Beta Thalassemia Major | PHASE2|PHASE3 | UNKNOWN | 2025-07-15 | Pediatric Hematology clinic, A... More >>in Shams University, Cairo, Egypt Less << |
NCT00529152 | Iron Overload | PHASE3 | COMPLETED | 2025-07-08 | Abo El Reish Hospital, Cairo U... More >>niversity, Cairo, Egypt|Children Hospital, Ain Shams University, Cairo, Egypt|Cipto Mangunkusumo National Hospital, Jakarta, 10010, Indonesia|University of Malaya Medical Center, Kuala Lumpur, 50603, Malaysia Less << |
NCT02635841 | Pantothenate Kinase-Associated... More >> Neurodegeneration Less << | NO_LONGER_AVAILABLE | - | - | |
NCT02191657 | HIV Infection | PHASE1 | COMPLETED | 2025-04-10 | PAREXEL International, Bloemfo... More >>ntein,, 9324, South Africa Less << |
NCT00907283 | Neurodegenerative Disease|Iron... More >> Overload Less << | PHASE2 | UNKNOWN | 2025-12-24 | Neurological Pathology Departm... More >>ent, Brotzu Hospital, Cagliari, 09134, Italy|Centre of Microcitemia and Congenital Anemias, Galliera Hospital, Genoa, 16128, Italy|Clinic of Neurology, University of Genoa, Genoa, 16132, Italy Less << |
NCT02477631 | Myelodysplastic Syndrome With ... More >>Low-grade Lesions|Iron Overload Due to Repeated Red Blood Cell Transfusions Less << | PHASE2 | COMPLETED | 2025-06-18 | Chim Sheba Medical Center, Tel... More >> Hashomer, 52621, Israel Less << |
NCT02164253 | ALS (Amyotrophic Lateral Scler... More >>osis)|Iron Overload Less << | PHASE2 | COMPLETED | 2025-12-16 | H?pital Roger Salengro, CHRU d... More >>e Lille, Lille, 59000, France Less << |
NCT01770652 | Renal Impairment | PHASE4 | COMPLETED | 2025-08-13 | H?pital Maisonneuve-Rosemont, ... More >>Montreal, Quebec, H1T2M4, Canada|Algorithme Pharma Inc., Mount-Royal, Quebec, H3P3P1, Canada Less << |
NCT02443545 | Iron Overload|Sickle Cell Dise... More >>ase|Other Anemias Less << | PHASE4 | TERMINATED | 2019-08-21 | UCSF Benioff Children's Hospit... More >>al Oakland, Oakland, California, 94609, United States|University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, 48109, United States|Children's Hospital of Michigan, Detroit, Michigan, 48201, United States|The Children's Hospital of Philadephia, Philadelphia, Pennsylvania, 19104-4399, United States|Medical University of South Carolina, Charleston, South Carolina, 29425, United States|Hospital for Sick Kids, Toronto, Ontario, Canada|Zagazig University, Alexandria, Egypt|Ain Shams University, Cairo, Egypt|Cairo University, Cairo, Egypt|Pediatric Hospital of Cairo University, Cairo, Egypt|Asser Central Hospital, Abha, Saudi Arabia|Barts and The London, London, United Kingdom|Evelina Children's Hospital, London, United Kingdom Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
7.19mL 1.44mL 0.72mL |
35.93mL 7.19mL 3.59mL |
71.86mL 14.37mL 7.19mL |
Tags: 30652-11-0 synthesis path| 30652-11-0 SDS| 30652-11-0 COA| 30652-11-0 purity| 30652-11-0 application| 30652-11-0 NMR| 30652-11-0 COA| 30652-11-0 structure
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