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Chemical Structure| 30389-33-4 Chemical Structure| 30389-33-4

Structure of 30389-33-4

Chemical Structure| 30389-33-4

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Product Details of [ 30389-33-4 ]

CAS No. :30389-33-4
Formula : C9H9NO2
M.W : 163.17
SMILES Code : OC1=CC=CC2=C1CCC(=O)N2
MDL No. :MFCD01862194
InChI Key :UTTJAIFHRUAFED-UHFFFAOYSA-N
Pubchem ID :169153

Safety of [ 30389-33-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 30389-33-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 30389-33-4 ]

[ 30389-33-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 30389-33-4 ]
  • [ 1196155-38-0 ]
  • 5-((4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)-3,4-dihydroquinolin-2(1H)-one [ No CAS ]
  • 2
  • [ 30389-33-4 ]
  • [ 1196155-38-0 ]
  • 2-((2-oxo-1,2,3,4-tetrahydroquinolin-5-yl)oxy)-6-(trifluoromethyl)isonicotinonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
49% With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 20℃; for 3h; To a stirred solution of 5-hydroxy-3,4-dihydroquinolin-2(lH)-one 1 (50 mg, 0.31 mmol) in N-methyl-2-pyrrolidone (3 mL) at RT, were added 2-chloro-6- (trifluoromethyl)isonicotinonitrile (63 mg, 0.31 mmol) and K2C03 (85 mg, 0.61 mmol). The mixture was stirred at RT for 3 h. The mixture was diluted with water (10 mL) and extracted with EtOAC (2 x 15 mL). The combined organic extracts were washed with brine (10 mL), dried (Na2S04), filtered, and concentrated under reduced pressure. The crude was triturated with Et20 (2 x 5 mL) to afford compound 2 (50 mg, 49percent) as white solid. 1H NMR (400 MHz, OMSO-d6): delta 10.28 (s, 1H), 8.18 (s, 1H), 7.97 (s, 1H), 7.23 (t, J= 8.0 Hz, 1H), 6.85-6.78 (m, 2H), 2.65 (t, J = 7.6 Hz, 2H), 2.42-2.35 (m, 2H); LC-MS (ESI): m/z 332.1 (M - 1).
 

Historical Records

Technical Information

• Acyl Group Substitution • Appel Reaction • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Chugaev Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Corey-Kim Oxidation • Dess-Martin Oxidation • Fischer Indole Synthesis • Grignard Reaction • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Jones Oxidation • Lawesson's Reagent • Leuckart-Wallach Reaction • Martin's Sulfurane Dehydrating Reagent • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mitsunobu Reaction • Moffatt Oxidation • Oxidation of Alcohols by DMSO • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Alcohols • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Alcohols • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions with Organometallic Reagents • Reformatsky Reaction • Ritter Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Sharpless Olefin Synthesis • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Stobbe Condensation • Swern Oxidation • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

Categories

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