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Chemical Structure| 30315-49-2 Chemical Structure| 30315-49-2

Structure of 30315-49-2

Chemical Structure| 30315-49-2

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Product Details of [ 30315-49-2 ]

CAS No. :30315-49-2
Formula : C14H21NO2
M.W : 235.32
SMILES Code : OCC1CN(C(C)(C)C)C(C2=CC=CC=C2)O1
MDL No. :MFCD00618541

Safety of [ 30315-49-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 30315-49-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 30315-49-2 ]

[ 30315-49-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 30315-49-2 ]
  • [ 74650-73-0 ]
  • (S) 2-(3-tert-butylamino-2-hydroxypropoxy)-5-methoxynicotinonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
0.55 g (47%) In N-methyl-acetamide; hydrogenchloride; mineral oil; EXAMPLE 2 Preparation of (S) 2-(tert-Butylamino-2-hydroxypropoxy)-5-methoxynicotinonitrile A stirred suspension of 50% sodium hydride in mineral oil (0.22 g., 0.045 mole) in dimethylformamide (35 ml.) was treated under nitrogen with (S) 2-phenyl-3-tert-butyl-5-hydroxymethyloxazolidine (1.06 g., 0.0045 mole) and heated on a steam bath for 20 minutes until hydrogen evolution ceased. After cooling to room temperature a solution of <strong>[74650-73-0]2-chloro-5-methoxynicotinonitrile</strong> (0.70 g., 0.0042 mole) in dimethylformamide (20 ml.) was added dropwise and the mixture stirred at room temperature for 21 hours. The mixture was poured into water (200 ml.) and extracted with ether (3*200 ml.). The combined extracts were washed with water, dried over sodium sulfate and concentrated under reduced pressure. The residue was heated on a steam bath in 1 N HCl (65 ml.) for 30 minutes. After cooling, the mixture was extracted with ether (2*50 ml.), the aqueous layer was carefully poured into saturated sodium carbonate solution (40 ml.) and extracted with CHCl3 (3*75 ml.). The solvent was concentrated under reduced pressure and the residue crystallized from hexane to yield 0.55 g (47%) of (S) 2-(3-tert-butylamino-2-hydroxypropoxy)-5-methoxynicotinonitrile melting at 97-98.5 C. Compounds of Formula II where R4 is STR8 are prepared from the corresponding compounds where R4 is OH by conventional acylation with an appropriate alkanoyl halide or alkanoic acid anhydride. This Formula II intermediate is then converted to the corresponding Formula I compound by substituting this intermediate for <strong>[74650-73-0]2-chloro-5-methoxynicotinonitrile</strong> in substantially the same procedure as Example 2.
 

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