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Chemical Structure| 29978-83-4 Chemical Structure| 29978-83-4

Structure of 29978-83-4

Chemical Structure| 29978-83-4

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Product Details of [ 29978-83-4 ]

CAS No. :29978-83-4
Formula : C10H8O2
M.W : 160.17
SMILES Code : O=CC1=CC=CC=C1OCC#C
MDL No. :MFCD02380378
InChI Key :PEERMPFPCWSJLC-UHFFFAOYSA-N
Pubchem ID :583037

Safety of [ 29978-83-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 29978-83-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 29978-83-4 ]

[ 29978-83-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 86-71-5 ]
  • [ 29978-83-4 ]
  • [ 1234193-33-9 ]
  • 2
  • [ 2417-90-5 ]
  • [ 13031-43-1 ]
  • [ 29978-83-4 ]
  • [ 1375304-43-0 ]
YieldReaction ConditionsOperation in experiment
65% With copper(II) sulfate; acetyl chloride; In dichloromethane; at 20℃; for 3h; General procedure: A round bottom flask is charged with propargyl derivative of 2-hydroxy benzaldehyde (320 mg, 2 mmol), 4-chloro acetophenone (309.18 mg, 2 mmol), acetyl chloride (2 mL), 3-bromopropionitrile (1 mL) and copper sulfate (100 mg) and kept under stirring for 3h at room temperature. The progress of the reaction was monitored by TLC analysis at regular intervals. After 3h, the mixture was quenched with cold water. The solid residue separated was collected and purified by passing it through a silica gel column. Elution of the column with petroleum ether (60-80 C) / ethyl acetate (9: 1 v/v) afforded 4d (664.13 mg, 74%).
 

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