29840-73-1|2-Bromoisonicotinamide| Ambeed

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Quality Control of [ 29840-73-1 ] Purity: 97% SDS Specification

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Product Details of [ 29840-73-1 ]

CAS No. :	29840-73-1
Formula :	C₆H₅BrN₂O
M.W :	201.02
SMILES Code :	NC(=O)C1=CC(Br)=NC=C1
MDL No. :	MFCD00234156
InChI Key :	KCELTDZFDHPTBI-UHFFFAOYSA-N
Pubchem ID :	4625407

Safety of [ 29840-73-1 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H319
Precautionary Statements:	P305+P351+P338

Application In Synthesis of [ 29840-73-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 29840-73-1 ]

[ 29840-73-1 ] Synthesis Path-Downstream 1~35

2
[ 29840-73-1 ]
1-(2-bromopyridin-4-yl)methanamine [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2005,vol. 13,p. 4022 - 4036.

3
[ 29840-73-1 ]
<i>N</i>-(2-bromo-pyridin-4-ylmethyl)-6-[4-(3-fluoro-benzyloxy)-phenoxy]-nicotinamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2005,vol. 13,p. 4022 - 4036.

4
[ 29840-73-1 ]
[ 1188-33-6 ]
[ 1207755-13-2 ]

Yield	Reaction Conditions	Operation in experiment
	at 120℃; for 1.5h;	2-bromo-isonicotinamide (406.2 mg, 2.021 mmol) and N,N-dimethylformamide diethyl acetal (0.48 ml, 2.80 mmol) were combined and heated to 120C. A short path distillation apparatus was used to collect the ethanol that was liberated during the reaction. The reaction mixture was a light orange solution that slowly turned darker until it had become a dark amber solution. After 1.5 hours, the reaction mixture was cooled to room temperature. The reaction mixture solidified upon cooling and was placed under high vacuum overnight to give the title compound (507.4 mg) as an off-white solid.1H NMR (CD3OD, 500 MHz, ppm) δ 3.27 (s, 3H, NMe), 3.29 (s, 3H, NMe), 8.05 (dd, 1H, ArH), 8.23 (d, 1H, ArH), 8.46 (d, 1H, ArH), 8.69 (s, 1H). Mass Spectrum: (ΕSI) m/z = 256.01 (258.01) (M+H).

References: [1]Patent: WO2010/19204,2010,A1 .Location in patent: Page/Page column 73.

5
[ 1315322-65-6 ]
[ 29840-73-1 ]
[ 1315322-69-0 ]

References: [1]Journal of Organic Chemistry,2011,vol. 76,p. 6394 - 6400.

6
7-tert-butoxycarbonyl-2-exo-(2’-fluoro-3‘-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5’-pyridinyl)-7-azabicyclo[2.2.1]heptane [ No CAS ]
[ 29840-73-1 ]
C₂₂H₂₅FN₄O₃ [ No CAS ]

References: [1]ACS Chemical Neuroscience,2016,vol. 7,p. 1004 - 1012.

7
[ 29840-73-1 ]
5′-(7-azabicyclo[2.2.1]hept-2-yl)-2′-fluoro-2,3′-bipyridine-4-carboxamide [ No CAS ]

References: [1]ACS Chemical Neuroscience,2016,vol. 7,p. 1004 - 1012.

8
[ 29840-73-1 ]
5′-(7-azabicyclo[2.2.1]hept-2-yl)-2′-fluoro-2,3′-bipyridine-4-carboxamide dihydrochloride [ No CAS ]

References: [1]ACS Chemical Neuroscience,2016,vol. 7,p. 1004 - 1012.

9
[ 29840-73-1 ]
[ 269410-24-4 ]
2-(1H-indol-5-yl)isonicotinamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
42%	With potassium acetate; In 1,4-dioxane; at 70℃;Inert atmosphere; Sealed tube;	General procedure: A mixture of a (243 mg, 1 mmol), 3-Amino-2-bromopyridine (187, 1.1 mmol), PdCl2(dppf) (51 mg, 0.07 mmol) and KOAc (300 g, 3 mmol) were added in 1,4-dioxane (4 ml). The suspension was bubbled with nitrogen for 20 min, and heated in a sealed tube at 60C for 6 h. The reaction process was similar as Zif-1.

References: [1]Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,p. 4150 - 4155.

10
[ 29840-73-1 ]
[ 536-33-4 ]