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Chemical Structure| 2949-22-6 Chemical Structure| 2949-22-6

Structure of 2949-22-6

Chemical Structure| 2949-22-6

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Product Details of [ 2949-22-6 ]

CAS No. :2949-22-6
Formula : C5H7NO3
M.W : 129.11
SMILES Code : O=C(OCC)CN=C=O
MDL No. :MFCD00002040
InChI Key :DUVOZUPPHBRJJO-UHFFFAOYSA-N
Pubchem ID :76283

Safety of [ 2949-22-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H227-H301-H331-H315-H319-H334-H335
Precautionary Statements:P210-P261-P264-P270-P271-P280-P284-P301+P310+P330-P302+P352-P304+P340+P311-P305+P351+P338-P332+P313-P337+P313-P342+P311-P362+P364-P370+P378-P403+P233-P403+P235-P405-P501
Class:6.1
UN#:2206
Packing Group:

Application In Synthesis of [ 2949-22-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2949-22-6 ]

[ 2949-22-6 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 22888-59-1 ]
  • [ 2949-22-6 ]
  • [ 340187-94-2 ]
  • 2
  • [ 7149-18-0 ]
  • [ 2949-22-6 ]
  • ethyl 2-[3-ethoxycarbonylmethylureido]cyclopentene-1-carboxylate [ No CAS ]
  • 3
  • [ 170017-74-0 ]
  • [ 2949-22-6 ]
  • 4-[2-(3-ethoxycarbonylmethyl-ureido)-phenyl]-piperazine-1-carboxylic acid <i>tert</i>-butyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; at 20℃; COMPOUND EXAMPLE 99; Step 1: To 4-Boc-1-(2-aniline)-piperazine 61 (1 eq., 200 mg, 0.72 mmol) in DCM (5 mL) was added ethyl isocyanatoacetate 100 (1.5 eq., 1.08 mmol, 123 uL) and triethylamine (6 eq., 4.32 mmol, 470 uL). The reaction was allowed to stir at room temperature under nitrogen overnight and was then diluted with ethyl acetate and saturated sodium bicarbonate solution. The organic phase was washed with brine, dried over sodium sulfate and concentrated. The product was purified using an RS-12 silica gel column and a gradient of ethyl acetate/hexanes from 0-40%. The product was then treated with a solution of HCl in dioxane as described previously in step 2 of Compound example 88 to give 101.
  • 4
  • [ 773-76-2 ]
  • [ 2949-22-6 ]
  • ethyl N-(((5,7-dichloro-8-quinolinyl)oxy)carbonyl)glycinate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In butanone; EXAMPLE 4 Ethyl N-(((5,7-dichloro-8-quinolinyl)oxy)carbonyl)glycinate <strong>[773-76-2]5,7-Dichloro-8-hydroxyquinoline</strong> (21.4 g), ethyl isocyanatoacetate (21.3 g) and triethylamine (1.0 ml) were mixed together in 400 ml of methyl ethyl ketone and stirred at room temperature for about 42 hours resulting in the precipitation of a white crystalline solid. This solid was removed from the reaction mixture by filtration and was determined to be the desired ethyl N-(((5,7-dichloro-8-quinolinyl)oxy)carbonyl)glycinate, m.p. 119.5 C.
 

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