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Chemical Structure| 29121-25-3 Chemical Structure| 29121-25-3

Structure of 29121-25-3

Chemical Structure| 29121-25-3

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Product Details of [ 29121-25-3 ]

CAS No. :29121-25-3
Formula : C10H11BrO3
M.W : 259.10
SMILES Code : O=C(CC1=CC=C(C(Br)=C1)O)OCC
MDL No. :MFCD16293380

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Application In Synthesis of [ 29121-25-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 29121-25-3 ]

[ 29121-25-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 327056-73-5 ]
  • [ 29121-25-3 ]
  • [ 1207542-34-4 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 110 - 120℃; for 1.41667h;Microwave; To a solution of 15 (1.6 g, 6.20 mmol) in NMP (12 mL) was added K2CO3 (2.56 g, 18.6 mmol) and <strong>[327056-73-5]3-chloro-5-fluorobenzonitrile</strong> (16, 0.96 g, 6.20 mmol). The reaction was heated in a laboratory microwave at 110 C. for 5 min and at 120 C. for 80 min. The reaction mixture was cooled to RT and diluted with 10% aqueous HCl. The mixture was extracted 3 times with EtOAc. The combined organics were washed with H2O and brine, dried (Na2SO4), filtered and evaporated in vacuo. The crude product was purified via SiO2 chromatography eluting with MeOH/hexane to afford 17a
 

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