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Chemical Structure| 2905-30-8 Chemical Structure| 2905-30-8

Structure of 2905-30-8

Chemical Structure| 2905-30-8

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Product Details of [ 2905-30-8 ]

CAS No. :2905-30-8
Formula : C8H9ClO2S
M.W : 204.67
SMILES Code : O=S(C1=CC=C(C)C(C)=C1)(Cl)=O
MDL No. :MFCD00625742
InChI Key :DNMQPRPJIWTNAX-UHFFFAOYSA-N
Pubchem ID :3689743

Safety of [ 2905-30-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 2905-30-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2905-30-8 ]

[ 2905-30-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2905-30-8 ]
  • [ 5930-94-9 ]
  • 1-((3,4-dimethylphenyl)sulfonyl)-3-nitro-1H-pyrrole [ No CAS ]
YieldReaction ConditionsOperation in experiment
With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20℃; To a stirred solution of<strong>[5930-94-9]3-nitro-1H-pyrrole</strong> (200 mg; 1.78 mmol) in CH2Cl2 (8 mL) was added 1,8-diazabicycloundec-7-ene, DBU, (347 μL; 2.32 mmol) followed by 3,4-dimethylbenzenesulfonyl chloride (438 mg; 2.14 mmol). The reaction wasstirred at rt overnight and then was diluted with CH2Cl2 and washed with 2 NHCl, satd NaHCO3, dried (MgSO4), filtered and concentrated under vacuum.Material was purified by CombiFlash (Isco-40 g column) eluting with 0-30%EtOAc/hexanes to give the final product (329 mg; 85%). LCMS: RT = 2.41 min,>98% at 215 nm, m/z = 219.1 [M+H]+.
  • 2
  • [ 6398-87-4 ]
  • [ 2905-30-8 ]
  • N-(3-formylphenyl)-3,4-dimethylbenzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
41% General procedure: To a stirred solution of compound 4 (0.50 g, 3 mmol) in 15 mLdichloromethane, pyridine (0.24 mL, 3 mmol) and correspondingbenzoyl chloride (3 mmol) were added at 0 C. The reaction mixturewas stirred for 30 min, after which it was washed with10 mL 4 N aqueous HCl solution and 10 mL saturated sodium chloridesolution. The organic layer was dried with anhydrous MgSO4and concentrated. The residue was dissolved in 20 mL dioxaneand then 15 mL of a 4 N aqueous HCl solution was added at roomtemperature. The reaction mixture was stirred at 50 C for 30 minafter which it was extracted with ethyl acetate (50 mL 3). Theextract was washed with saturated sodium chloride solution anddried with anhydrous MgSO4. After concentration, column chromatographyof the residue on silica gel (eluent PE/EA 7:1) generatedcompounds 5a-o. The spectral data are summarized in theSupplementary Information.
 

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