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Chemical Structure| 287172-65-0 Chemical Structure| 287172-65-0

Structure of 287172-65-0

Chemical Structure| 287172-65-0

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Product Details of [ 287172-65-0 ]

CAS No. :287172-65-0
Formula : C6H4BrF2NO2S
M.W : 272.07
SMILES Code : O=S(C1=CC(Br)=C(F)C=C1F)(N)=O
MDL No. :MFCD01940425

Safety of [ 287172-65-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H312-H314-H332
Precautionary Statements:P260-P261-P264-P270-P271-P280-P301+P312-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P310-P312-P321-P322-P330-P363-P405-P501
Class:8
UN#:1759
Packing Group:

Application In Synthesis of [ 287172-65-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 287172-65-0 ]

[ 287172-65-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 287172-65-0 ]
  • [ 1235406-42-4 ]
  • tert-butyl [(5-bromo-2,4-difluorophenyl)sulfonyl]-1,3-thiazol-4-ylcarbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
Preparation 38 Tert-butyl[(5-bromo-2,4-difluorophenyl)sulfonyl]1,3-thiazol-4-ylcarbamate To a solution of thiazole-4-yl-carbamic acid tert-butyl ester (WO201004707, 1650 mg, 8.23 mmol) in THF (29.3 mL) was added LiHMDS (8.23 mL, 8.23 mmol) at 0 C. After stirring for 1 hour at this temperature, the reaction mixture was cooled to -78 C. and 2,4-difluoro-5-bromobenzenesulfonamide (2000 mg, 6.86 mmol) in THF (5.0 mL) was added. The mixture was allowed to warm to room temperature over 18 hours. The reaction was quenched by the addition of saturated aqueous ammonium chloride solution (60 mL) and extracted into DCM. The organic layer was collected, dried over MgSO4 and concentrated in vacuo. The residue was dissolved in DCM (10 mL), TFA (10 mL) was added and the reaction mixture stirred at room temperature for 18 hours. The reaction mixture was concentrated in vacuo and purified using silica gel column chromatography eluting with 50:50 EtOAc:Heptane to afford the title compound as a white solid (2.08 g, 85%). 1H NMR (400 MHz, DMSO-d6): delta ppm 1.35 (s, 9H), 7.10 (s, 1H), 7.75 (m, 1H), 8.10 (m, 1H), 8.90 (m, 1H), 11.45 (br s, 1H).
 

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