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Chemical Structure| 28682-68-0 Chemical Structure| 28682-68-0

Structure of 28682-68-0

Chemical Structure| 28682-68-0

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Product Details of [ 28682-68-0 ]

CAS No. :28682-68-0
Formula : C4H2Cl2N4O2
M.W : 208.99
SMILES Code : NC1=C([N+]([O-])=O)C(Cl)=NN=C1Cl
MDL No. :MFCD11870219
InChI Key :YFPAFTNZJFLJNW-UHFFFAOYSA-N
Pubchem ID :12913093

Safety of [ 28682-68-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 28682-68-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 28682-68-0 ]
  • Downstream synthetic route of [ 28682-68-0 ]

[ 28682-68-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 823-58-5 ]
  • [ 28682-68-0 ]
YieldReaction ConditionsOperation in experiment
45% at 0 - 60℃; for 3 h; The commercially available 3,6-dichloropyridazine-4-amine (15 g, 92 mmol, 1 eq.) was added dropwise to the solution of fuming ΗΝΟ3 (12 ml, 290 mmol, 3.15 eq.) in cone. H2SO4 (60 ml) at 0°C. The mixture was stirred at 60°C for 3 h. The reaction mixture was poured into crushed ice carefully, neutralized to pH=7 with aqueous NaOH solution. The solution was extracted with CH2CI2, washed with brine, dried over Na2S04. The solvent was removed under vacuum. The residue was washed with t-butyl methyl ether to give pure intermediate 1 1 (8.5 g, 45percent yield).
References: [1] Patent: WO2014/114776, 2014, A1, . Location in patent: Page/Page column 25.
 

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